The ketogenic diet for the treatment of malignant glioma
Advances in our understanding of glioma biology has led to an increase in targeted therapies in preclinical and clinical trials; however, cellular heterogeneity often precludes the targeted molecules from being found on all glioma cells, thus reducing the efficacy of these treatments. In contrast, o...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520356352 |
| _version_ | 1818386417387044864 |
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| author | Eric C. Woolf Adrienne C. Scheck |
| author_facet | Eric C. Woolf Adrienne C. Scheck |
| author_sort | Eric C. Woolf |
| collection | DOAJ |
| description | Advances in our understanding of glioma biology has led to an increase in targeted therapies in preclinical and clinical trials; however, cellular heterogeneity often precludes the targeted molecules from being found on all glioma cells, thus reducing the efficacy of these treatments. In contrast, one trait shared by virtually all tumor cells is altered (dysregulated) metabolism. Tumor cells have an increased reliance on glucose, suggesting that treatments affecting cellular metabolism may be an effective method to improve current therapies. Indeed, metabolism has been a focus of cancer research in the last few years, as many pathways long associated with tumor growth have been found to intersect metabolic pathways in the cell. The ketogenic diet (high fat, low carbohydrate and protein), caloric restriction, and fasting all cause a metabolic change, specifically, a reduction in blood glucose and an increase in blood ketones. We, and others, have demonstrated that these metabolic changes improve survival in animal models of malignant gliomas and can potentiate the anti-tumor effect of chemotherapies and radiation treatment. In this review we discuss the use of metabolic alteration for the treatment of malignant brain tumors. |
| first_indexed | 2024-12-14T03:53:43Z |
| format | Article |
| id | doaj.art-30d0c94f92bc4207909efbd26c5160ff |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-14T03:53:43Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-30d0c94f92bc4207909efbd26c5160ff2022-12-21T23:18:09ZengElsevierJournal of Lipid Research0022-22752015-01-01561510The ketogenic diet for the treatment of malignant gliomaEric C. Woolf0Adrienne C. Scheck1Neuro-Oncology Research, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013To whom correspondence should be addressed; Neuro-Oncology Research, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013Advances in our understanding of glioma biology has led to an increase in targeted therapies in preclinical and clinical trials; however, cellular heterogeneity often precludes the targeted molecules from being found on all glioma cells, thus reducing the efficacy of these treatments. In contrast, one trait shared by virtually all tumor cells is altered (dysregulated) metabolism. Tumor cells have an increased reliance on glucose, suggesting that treatments affecting cellular metabolism may be an effective method to improve current therapies. Indeed, metabolism has been a focus of cancer research in the last few years, as many pathways long associated with tumor growth have been found to intersect metabolic pathways in the cell. The ketogenic diet (high fat, low carbohydrate and protein), caloric restriction, and fasting all cause a metabolic change, specifically, a reduction in blood glucose and an increase in blood ketones. We, and others, have demonstrated that these metabolic changes improve survival in animal models of malignant gliomas and can potentiate the anti-tumor effect of chemotherapies and radiation treatment. In this review we discuss the use of metabolic alteration for the treatment of malignant brain tumors.http://www.sciencedirect.com/science/article/pii/S0022227520356352metabolismcancerbrain tumorketonestherapycaloric restriction |
| spellingShingle | Eric C. Woolf Adrienne C. Scheck The ketogenic diet for the treatment of malignant glioma Journal of Lipid Research metabolism cancer brain tumor ketones therapy caloric restriction |
| title | The ketogenic diet for the treatment of malignant glioma |
| title_full | The ketogenic diet for the treatment of malignant glioma |
| title_fullStr | The ketogenic diet for the treatment of malignant glioma |
| title_full_unstemmed | The ketogenic diet for the treatment of malignant glioma |
| title_short | The ketogenic diet for the treatment of malignant glioma |
| title_sort | ketogenic diet for the treatment of malignant glioma |
| topic | metabolism cancer brain tumor ketones therapy caloric restriction |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520356352 |
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