The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage
The aim of the present study is to evaluate the protective effect of polysaccharide from the Brown Seaweed Sargassum graminifolium (SGP) on ethylene glycol-induced kidney damage and the mechanism of SGP-mediated protection. Mitochondrial lipid peroxidation, mitochondrial swelling, the activity of su...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-03-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/11/3/870 |
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| author | Wen-Hui Wu Min-Bo Lan Ting Kong Chao-Yan Zhang |
| author_facet | Wen-Hui Wu Min-Bo Lan Ting Kong Chao-Yan Zhang |
| author_sort | Wen-Hui Wu |
| collection | DOAJ |
| description | The aim of the present study is to evaluate the protective effect of polysaccharide from the Brown Seaweed Sargassum graminifolium (SGP) on ethylene glycol-induced kidney damage and the mechanism of SGP-mediated protection. Mitochondrial lipid peroxidation, mitochondrial swelling, the activity of succinate dehydrogenase (SDH), ATPases and mitochondrial antioxidant enzymes was observed in hyperoxaluric rats. Administration of SGP (25, 100 and 400 mg·kg−1, intragastrically) increased the activities of antioxidant enzymes, SDH and Na+/K+-ATPases, Ca2+-ATPases, Mg2+-ATPases, also decreased mitochondrial lipid peroxidation and mitochondrial swelling. SGP exhibited a protective effect by improving antioxidant enzymes and restoring mitochondrial dysfunction in the kidney of hyperoxaluric rats. It may be used as a promising therapeutic agent to provide superior renal protection. |
| first_indexed | 2024-04-11T22:05:51Z |
| format | Article |
| id | doaj.art-30d0ff3b2a5a4b079b0d756ea8bd03f5 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T22:05:51Z |
| publishDate | 2013-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-30d0ff3b2a5a4b079b0d756ea8bd03f52022-12-22T04:00:43ZengMDPI AGMarine Drugs1660-33972013-03-0111387088010.3390/md11030870The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial DamageWen-Hui WuMin-Bo LanTing KongChao-Yan ZhangThe aim of the present study is to evaluate the protective effect of polysaccharide from the Brown Seaweed Sargassum graminifolium (SGP) on ethylene glycol-induced kidney damage and the mechanism of SGP-mediated protection. Mitochondrial lipid peroxidation, mitochondrial swelling, the activity of succinate dehydrogenase (SDH), ATPases and mitochondrial antioxidant enzymes was observed in hyperoxaluric rats. Administration of SGP (25, 100 and 400 mg·kg−1, intragastrically) increased the activities of antioxidant enzymes, SDH and Na+/K+-ATPases, Ca2+-ATPases, Mg2+-ATPases, also decreased mitochondrial lipid peroxidation and mitochondrial swelling. SGP exhibited a protective effect by improving antioxidant enzymes and restoring mitochondrial dysfunction in the kidney of hyperoxaluric rats. It may be used as a promising therapeutic agent to provide superior renal protection.http://www.mdpi.com/1660-3397/11/3/870polysaccharidemitochondrial damagehyperoxaluricurinary stonesreactive oxygen species (ROS) |
| spellingShingle | Wen-Hui Wu Min-Bo Lan Ting Kong Chao-Yan Zhang The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage Marine Drugs polysaccharide mitochondrial damage hyperoxaluric urinary stones reactive oxygen species (ROS) |
| title | The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage |
| title_full | The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage |
| title_fullStr | The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage |
| title_full_unstemmed | The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage |
| title_short | The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage |
| title_sort | protection of polysaccharide from the brown seaweed sargassum graminifolium against ethylene glycol induced mitochondrial damage |
| topic | polysaccharide mitochondrial damage hyperoxaluric urinary stones reactive oxygen species (ROS) |
| url | http://www.mdpi.com/1660-3397/11/3/870 |
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