Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non‐infectious uveitis
Abstract Characterised by intraocular inflammation, non‐infectious uveitis includes a large group of autoimmune and autoinflammatory diseases that either involve the eye alone or have both ocular and systemic manifestations. When non‐infectious uveitis involves the posterior segment of the eye, spec...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | Clinical & Translational Immunology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cti2.1479 |
| _version_ | 1797376477948280832 |
|---|---|
| author | Lisia Barros Ferreira Keryn A Williams Giles Best Cameron D Haydinger Justine R Smith |
| author_facet | Lisia Barros Ferreira Keryn A Williams Giles Best Cameron D Haydinger Justine R Smith |
| author_sort | Lisia Barros Ferreira |
| collection | DOAJ |
| description | Abstract Characterised by intraocular inflammation, non‐infectious uveitis includes a large group of autoimmune and autoinflammatory diseases that either involve the eye alone or have both ocular and systemic manifestations. When non‐infectious uveitis involves the posterior segment of the eye, specifically the retina, there is substantial risk of vision loss, often linked to breakdown of the inner blood‐retinal barrier. This barrier is formed by non‐fenestrated retinal vascular endothelial cells, reinforced by supporting cells that include pericytes, Müller cells and astrocytes. Across the published literature, a group of inflammatory cytokines stand out as prominent mediators of intraocular inflammation, with effects on the retinal endothelium that may contribute to breakdown of the inner blood‐retinal barrier, namely tumour necrosis factor (TNF)‐α, interleukin (IL)‐1β, IL‐6, IL‐8, IL‐17 and chemokine C‐C motif ligand (CCL)2. This article reviews the function of each cytokine and discusses the evidence for their involvement in retinal endothelial barrier dysfunction in non‐infectious uveitis, including basic laboratory investigations, studies of ocular fluids collected from patients with non‐infectious uveitis, and results of clinical treatment trials. The review also outlines gaps in knowledge in this area. Understanding the disease processes at a molecular level can suggest treatment alternatives that are directed against appropriate biological targets to protect the posterior segment of eye and preserve vision in non‐infectious uveitis. |
| first_indexed | 2024-03-08T19:39:13Z |
| format | Article |
| id | doaj.art-30d3384039c84a79a8bc7c05d367f71a |
| institution | Directory Open Access Journal |
| issn | 2050-0068 |
| language | English |
| last_indexed | 2024-03-08T19:39:13Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical & Translational Immunology |
| spelling | doaj.art-30d3384039c84a79a8bc7c05d367f71a2023-12-25T11:04:35ZengWileyClinical & Translational Immunology2050-00682023-01-011212n/an/a10.1002/cti2.1479Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non‐infectious uveitisLisia Barros Ferreira0Keryn A Williams1Giles Best2Cameron D Haydinger3Justine R Smith4Flinders University College of Medicine and Public Health Adelaide SA AustraliaFlinders University College of Medicine and Public Health Adelaide SA AustraliaFlinders University College of Medicine and Public Health Adelaide SA AustraliaFlinders University College of Medicine and Public Health Adelaide SA AustraliaFlinders University College of Medicine and Public Health Adelaide SA AustraliaAbstract Characterised by intraocular inflammation, non‐infectious uveitis includes a large group of autoimmune and autoinflammatory diseases that either involve the eye alone or have both ocular and systemic manifestations. When non‐infectious uveitis involves the posterior segment of the eye, specifically the retina, there is substantial risk of vision loss, often linked to breakdown of the inner blood‐retinal barrier. This barrier is formed by non‐fenestrated retinal vascular endothelial cells, reinforced by supporting cells that include pericytes, Müller cells and astrocytes. Across the published literature, a group of inflammatory cytokines stand out as prominent mediators of intraocular inflammation, with effects on the retinal endothelium that may contribute to breakdown of the inner blood‐retinal barrier, namely tumour necrosis factor (TNF)‐α, interleukin (IL)‐1β, IL‐6, IL‐8, IL‐17 and chemokine C‐C motif ligand (CCL)2. This article reviews the function of each cytokine and discusses the evidence for their involvement in retinal endothelial barrier dysfunction in non‐infectious uveitis, including basic laboratory investigations, studies of ocular fluids collected from patients with non‐infectious uveitis, and results of clinical treatment trials. The review also outlines gaps in knowledge in this area. Understanding the disease processes at a molecular level can suggest treatment alternatives that are directed against appropriate biological targets to protect the posterior segment of eye and preserve vision in non‐infectious uveitis.https://doi.org/10.1002/cti2.1479cytokineendothelial cellendotheliuminflammationretinauveitis |
| spellingShingle | Lisia Barros Ferreira Keryn A Williams Giles Best Cameron D Haydinger Justine R Smith Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non‐infectious uveitis Clinical & Translational Immunology cytokine endothelial cell endothelium inflammation retina uveitis |
| title | Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non‐infectious uveitis |
| title_full | Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non‐infectious uveitis |
| title_fullStr | Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non‐infectious uveitis |
| title_full_unstemmed | Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non‐infectious uveitis |
| title_short | Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non‐infectious uveitis |
| title_sort | inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non infectious uveitis |
| topic | cytokine endothelial cell endothelium inflammation retina uveitis |
| url | https://doi.org/10.1002/cti2.1479 |
| work_keys_str_mv | AT lisiabarrosferreira inflammatorycytokinesasmediatorsofretinalendothelialbarrierdysfunctioninnoninfectiousuveitis AT kerynawilliams inflammatorycytokinesasmediatorsofretinalendothelialbarrierdysfunctioninnoninfectiousuveitis AT gilesbest inflammatorycytokinesasmediatorsofretinalendothelialbarrierdysfunctioninnoninfectiousuveitis AT camerondhaydinger inflammatorycytokinesasmediatorsofretinalendothelialbarrierdysfunctioninnoninfectiousuveitis AT justinersmith inflammatorycytokinesasmediatorsofretinalendothelialbarrierdysfunctioninnoninfectiousuveitis |