Targeting NLRP3 Inflammasome in the Treatment of CNS Diseases
Central nervous system (CNS) is one of the largest killers of people’s health all over the world. The overactivation of the immune and inflammatory responses is considered as an important factor, contributing to the pathogenesis and progression of CNS disorders. Among all kinds of immune and inflamm...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnmol.2018.00320/full |
| _version_ | 1811277058279473152 |
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| author | Bo-Zong Shao Qi Cao Chong Liu |
| author_facet | Bo-Zong Shao Qi Cao Chong Liu |
| author_sort | Bo-Zong Shao |
| collection | DOAJ |
| description | Central nervous system (CNS) is one of the largest killers of people’s health all over the world. The overactivation of the immune and inflammatory responses is considered as an important factor, contributing to the pathogenesis and progression of CNS disorders. Among all kinds of immune and inflammatory reaction, the inflammasome, a complex of proteins, has been drawn increasingly attention to by researchers. The initiation and activation of the inflammasome is involved in the onset of various kinds of diseases. The NLRP3 inflammasome, the most studied member of the inflammasome, is closely associated with many kinds of CNS disorders. Here in this review, the roles of the NLRP3 inflammasome in the pathogenesis and progression of several well-known CNS diseases would be discussed, including cerebrovascular diseases, neurodegenerative diseases, multiple sclerosis, depression as well as other CNS disorders. In addition, several therapeutic strategies targeting on the NLRP3 inflammasome for the treatment of CNS disorders would be described in this review. |
| first_indexed | 2024-04-13T00:08:55Z |
| format | Article |
| id | doaj.art-30d42b4feee34ca0b4e2b588314c206d |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-13T00:08:55Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-30d42b4feee34ca0b4e2b588314c206d2022-12-22T03:11:09ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992018-09-011110.3389/fnmol.2018.00320392778Targeting NLRP3 Inflammasome in the Treatment of CNS DiseasesBo-Zong ShaoQi CaoChong LiuCentral nervous system (CNS) is one of the largest killers of people’s health all over the world. The overactivation of the immune and inflammatory responses is considered as an important factor, contributing to the pathogenesis and progression of CNS disorders. Among all kinds of immune and inflammatory reaction, the inflammasome, a complex of proteins, has been drawn increasingly attention to by researchers. The initiation and activation of the inflammasome is involved in the onset of various kinds of diseases. The NLRP3 inflammasome, the most studied member of the inflammasome, is closely associated with many kinds of CNS disorders. Here in this review, the roles of the NLRP3 inflammasome in the pathogenesis and progression of several well-known CNS diseases would be discussed, including cerebrovascular diseases, neurodegenerative diseases, multiple sclerosis, depression as well as other CNS disorders. In addition, several therapeutic strategies targeting on the NLRP3 inflammasome for the treatment of CNS disorders would be described in this review.https://www.frontiersin.org/article/10.3389/fnmol.2018.00320/fullNLRP3 inflammasomeCNS diseasesinnate immunityinhibitorspharmacological application |
| spellingShingle | Bo-Zong Shao Qi Cao Chong Liu Targeting NLRP3 Inflammasome in the Treatment of CNS Diseases Frontiers in Molecular Neuroscience NLRP3 inflammasome CNS diseases innate immunity inhibitors pharmacological application |
| title | Targeting NLRP3 Inflammasome in the Treatment of CNS Diseases |
| title_full | Targeting NLRP3 Inflammasome in the Treatment of CNS Diseases |
| title_fullStr | Targeting NLRP3 Inflammasome in the Treatment of CNS Diseases |
| title_full_unstemmed | Targeting NLRP3 Inflammasome in the Treatment of CNS Diseases |
| title_short | Targeting NLRP3 Inflammasome in the Treatment of CNS Diseases |
| title_sort | targeting nlrp3 inflammasome in the treatment of cns diseases |
| topic | NLRP3 inflammasome CNS diseases innate immunity inhibitors pharmacological application |
| url | https://www.frontiersin.org/article/10.3389/fnmol.2018.00320/full |
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