MiniMed 780G™ advanced hybrid closed-loop system performance in Egyptian patients with type 1 diabetes across different age groups: evidence from real-world users
Abstract Background Advanced hybrid closed loop (AHCL) system provides both automated basal rate and correction boluses to keep glycemic values in a target range. Objectives To evaluate the real-world performance of the MiniMed™ 780G system among different age groups of Egyptian patients with type 1...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-023-01184-w |
| _version_ | 1797451944789278720 |
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| author | Nancy Samir Elbarbary Eman Abdel Rahman Ismail |
| author_facet | Nancy Samir Elbarbary Eman Abdel Rahman Ismail |
| author_sort | Nancy Samir Elbarbary |
| collection | DOAJ |
| description | Abstract Background Advanced hybrid closed loop (AHCL) system provides both automated basal rate and correction boluses to keep glycemic values in a target range. Objectives To evaluate the real-world performance of the MiniMed™ 780G system among different age groups of Egyptian patients with type 1diabetes. Methods One-hundred seven AHCL system users aged from 3 to 71 years were enrolled. Data uploaded by patients were aggregated and analyzed. The mean glucose management indicator (GMI), percentage of time spent within glycemic ranges (TIR), time below range (TBR) and time above range (TAR) were determined. Results Six months after initiating Auto Mode, patients spent a mean of 85.31 ± 22.04% of the time in Auto Mode (SmartGuard) and achieved a mean GMI of 6.95 ± 0.58% compared with 7.9 ± 2.1% before AHCL initiation (p < 0.001). TIR 70–180 mg/dL was increased post-AHCL initiation from 63.48 ± 10.14% to 81.54 ± 8.43% (p < 0.001) while TAR 180–250 mg/dL, TAR > 250 mg/dL, TBR < 70 mg/dL and TBR < 54 mg/dL were significantly decreased (p < 0.001). After initiating AHCL, TIR was greater in children and adults compared with adolescents (82.29 ± 7.22% and 83.86 ± 9.24% versus 78.4 ± 7.34%, respectively; p < 0.05). The total daily dose of insulin was increased in all age groups primarily due to increased system-initiated insulin delivery including auto correction boluses and basal insulin. Conclusions MiniMed™ 780G system users across different age groups achieved international consensus-recommended glycemic control with no serious adverse effects even in challenging age group as children and adolescents. |
| first_indexed | 2024-03-09T15:01:48Z |
| format | Article |
| id | doaj.art-30d6f337a7d84d96a532b9f96f56de48 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-03-09T15:01:48Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-30d6f337a7d84d96a532b9f96f56de482023-11-26T13:52:03ZengBMCDiabetology & Metabolic Syndrome1758-59962023-10-011511910.1186/s13098-023-01184-wMiniMed 780G™ advanced hybrid closed-loop system performance in Egyptian patients with type 1 diabetes across different age groups: evidence from real-world usersNancy Samir Elbarbary0Eman Abdel Rahman Ismail1Department of Pediatrics, Faculty of medicine, Ain shams UniversityDepartment of Clinical Pathology, Faculty of medicine, Ain shams UniversityAbstract Background Advanced hybrid closed loop (AHCL) system provides both automated basal rate and correction boluses to keep glycemic values in a target range. Objectives To evaluate the real-world performance of the MiniMed™ 780G system among different age groups of Egyptian patients with type 1diabetes. Methods One-hundred seven AHCL system users aged from 3 to 71 years were enrolled. Data uploaded by patients were aggregated and analyzed. The mean glucose management indicator (GMI), percentage of time spent within glycemic ranges (TIR), time below range (TBR) and time above range (TAR) were determined. Results Six months after initiating Auto Mode, patients spent a mean of 85.31 ± 22.04% of the time in Auto Mode (SmartGuard) and achieved a mean GMI of 6.95 ± 0.58% compared with 7.9 ± 2.1% before AHCL initiation (p < 0.001). TIR 70–180 mg/dL was increased post-AHCL initiation from 63.48 ± 10.14% to 81.54 ± 8.43% (p < 0.001) while TAR 180–250 mg/dL, TAR > 250 mg/dL, TBR < 70 mg/dL and TBR < 54 mg/dL were significantly decreased (p < 0.001). After initiating AHCL, TIR was greater in children and adults compared with adolescents (82.29 ± 7.22% and 83.86 ± 9.24% versus 78.4 ± 7.34%, respectively; p < 0.05). The total daily dose of insulin was increased in all age groups primarily due to increased system-initiated insulin delivery including auto correction boluses and basal insulin. Conclusions MiniMed™ 780G system users across different age groups achieved international consensus-recommended glycemic control with no serious adverse effects even in challenging age group as children and adolescents.https://doi.org/10.1186/s13098-023-01184-wType 1 DiabetesAutomated insulin delivery (AID)Advanced hybrid closed loop (AHCL)Minimed™ 780Glucose management indicatorTime in range (TIR) |
| spellingShingle | Nancy Samir Elbarbary Eman Abdel Rahman Ismail MiniMed 780G™ advanced hybrid closed-loop system performance in Egyptian patients with type 1 diabetes across different age groups: evidence from real-world users Diabetology & Metabolic Syndrome Type 1 Diabetes Automated insulin delivery (AID) Advanced hybrid closed loop (AHCL) Minimed™ 780 Glucose management indicator Time in range (TIR) |
| title | MiniMed 780G™ advanced hybrid closed-loop system performance in Egyptian patients with type 1 diabetes across different age groups: evidence from real-world users |
| title_full | MiniMed 780G™ advanced hybrid closed-loop system performance in Egyptian patients with type 1 diabetes across different age groups: evidence from real-world users |
| title_fullStr | MiniMed 780G™ advanced hybrid closed-loop system performance in Egyptian patients with type 1 diabetes across different age groups: evidence from real-world users |
| title_full_unstemmed | MiniMed 780G™ advanced hybrid closed-loop system performance in Egyptian patients with type 1 diabetes across different age groups: evidence from real-world users |
| title_short | MiniMed 780G™ advanced hybrid closed-loop system performance in Egyptian patients with type 1 diabetes across different age groups: evidence from real-world users |
| title_sort | minimed 780g™ advanced hybrid closed loop system performance in egyptian patients with type 1 diabetes across different age groups evidence from real world users |
| topic | Type 1 Diabetes Automated insulin delivery (AID) Advanced hybrid closed loop (AHCL) Minimed™ 780 Glucose management indicator Time in range (TIR) |
| url | https://doi.org/10.1186/s13098-023-01184-w |
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