Biomechanical Variability and Usability of a Novel Customizable Fracture Fixation Technique
A novel in situ customizable osteosynthesis technique, Bonevolent™ AdhFix, demonstrates promising biomechanical properties under the expertise of a single trained operator. This study assesses inter- and intra-surgeon biomechanical variability and usability of the AdhFix osteosynthesis platform. Six...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/10/10/1146 |
| _version_ | 1797574645687255040 |
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| author | Thomas Colding-Rasmussen Peter Schwarzenberg Peter Frederik Horstmann Casper Bent Smedegaard Ottesen Jorge San Jacinto Garcia Daniel John Hutchinson Michael Malkoch Michael Mørk Petersen Peter Varga Christian Nai En Tierp-Wong |
| author_facet | Thomas Colding-Rasmussen Peter Schwarzenberg Peter Frederik Horstmann Casper Bent Smedegaard Ottesen Jorge San Jacinto Garcia Daniel John Hutchinson Michael Malkoch Michael Mørk Petersen Peter Varga Christian Nai En Tierp-Wong |
| author_sort | Thomas Colding-Rasmussen |
| collection | DOAJ |
| description | A novel in situ customizable osteosynthesis technique, Bonevolent™ AdhFix, demonstrates promising biomechanical properties under the expertise of a single trained operator. This study assesses inter- and intra-surgeon biomechanical variability and usability of the AdhFix osteosynthesis platform. Six surgeons conducted ten osteosyntheses on a synthetic bone fracture model after reviewing an instruction manual and completing one supervised osteosynthesis. Samples underwent 4-point bending tests at a quasi-static loading rate, and the maximum bending moment (BM), bending stiffness (BS), and AdhFix cross-sectional area (CSA: mm²) were evaluated. All constructs exhibited a consistent appearance and were suitable for biomechanical testing. The mean BM was 2.64 ± 0.57 Nm, and the mean BS was 4.35 ± 0.44 Nm/mm. Statistically significant differences were observed among the six surgeons in BM (<i>p</i> < 0.001) and BS (<i>p</i> = 0.004). Throughout ten trials, only one surgeon demonstrated a significant improvement in BM (<i>p</i> < 0.025), and another showed a significant improvement in BS (<i>p</i> < 0.01). A larger CSA corresponded to a statistically significantly higher value for BM (<i>p</i> < 0.001) but not for BS (<i>p</i> = 0.594). In conclusion, this study found consistent biomechanical stability both across and within the surgeons included, suggesting that the AdhFix osteosynthesis platform can be learned and applied with minimal training and, therefore, might be a clinically viable fracture fixation technique. The variability in BM and BS observed is not expected to have a clinical impact, but future clinical studies are warranted. |
| first_indexed | 2024-03-10T21:26:13Z |
| format | Article |
| id | doaj.art-30d7318139174b1fa027cc8dab8ebb1a |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T21:26:13Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-30d7318139174b1fa027cc8dab8ebb1a2023-11-19T15:41:38ZengMDPI AGBioengineering2306-53542023-09-011010114610.3390/bioengineering10101146Biomechanical Variability and Usability of a Novel Customizable Fracture Fixation TechniqueThomas Colding-Rasmussen0Peter Schwarzenberg1Peter Frederik Horstmann2Casper Bent Smedegaard Ottesen3Jorge San Jacinto Garcia4Daniel John Hutchinson5Michael Malkoch6Michael Mørk Petersen7Peter Varga8Christian Nai En Tierp-Wong9Department of Orthopedic Surgery, Hvidovre University Hospital, Kettegaard Allé 30, 2650 Hvidovre, DenmarkAO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos, SwitzerlandDepartment of Orthopedic Surgery, Gentofte Hospital, Gentofte Hospitalsvej 1, 2900 Hellerup, DenmarkDepartment of Orthopedic Surgery, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, DenmarkDepartment of Fibre and Polymer Technology, KTH Royal Institute of Technology, Brinellvägen 8, 10044 Stockholm, SwedenDepartment of Fibre and Polymer Technology, KTH Royal Institute of Technology, Brinellvägen 8, 10044 Stockholm, SwedenDepartment of Fibre and Polymer Technology, KTH Royal Institute of Technology, Brinellvägen 8, 10044 Stockholm, SwedenDepartment of Orthopedic Surgery, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, DenmarkAO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos, SwitzerlandDepartment of Orthopedic Surgery, Hvidovre University Hospital, Kettegaard Allé 30, 2650 Hvidovre, DenmarkA novel in situ customizable osteosynthesis technique, Bonevolent™ AdhFix, demonstrates promising biomechanical properties under the expertise of a single trained operator. This study assesses inter- and intra-surgeon biomechanical variability and usability of the AdhFix osteosynthesis platform. Six surgeons conducted ten osteosyntheses on a synthetic bone fracture model after reviewing an instruction manual and completing one supervised osteosynthesis. Samples underwent 4-point bending tests at a quasi-static loading rate, and the maximum bending moment (BM), bending stiffness (BS), and AdhFix cross-sectional area (CSA: mm²) were evaluated. All constructs exhibited a consistent appearance and were suitable for biomechanical testing. The mean BM was 2.64 ± 0.57 Nm, and the mean BS was 4.35 ± 0.44 Nm/mm. Statistically significant differences were observed among the six surgeons in BM (<i>p</i> < 0.001) and BS (<i>p</i> = 0.004). Throughout ten trials, only one surgeon demonstrated a significant improvement in BM (<i>p</i> < 0.025), and another showed a significant improvement in BS (<i>p</i> < 0.01). A larger CSA corresponded to a statistically significantly higher value for BM (<i>p</i> < 0.001) but not for BS (<i>p</i> = 0.594). In conclusion, this study found consistent biomechanical stability both across and within the surgeons included, suggesting that the AdhFix osteosynthesis platform can be learned and applied with minimal training and, therefore, might be a clinically viable fracture fixation technique. The variability in BM and BS observed is not expected to have a clinical impact, but future clinical studies are warranted.https://www.mdpi.com/2306-5354/10/10/1146in situ customizable osteosynthesispatient-specific osteosynthesisusabilityvariabilitysurgical skills |
| spellingShingle | Thomas Colding-Rasmussen Peter Schwarzenberg Peter Frederik Horstmann Casper Bent Smedegaard Ottesen Jorge San Jacinto Garcia Daniel John Hutchinson Michael Malkoch Michael Mørk Petersen Peter Varga Christian Nai En Tierp-Wong Biomechanical Variability and Usability of a Novel Customizable Fracture Fixation Technique Bioengineering in situ customizable osteosynthesis patient-specific osteosynthesis usability variability surgical skills |
| title | Biomechanical Variability and Usability of a Novel Customizable Fracture Fixation Technique |
| title_full | Biomechanical Variability and Usability of a Novel Customizable Fracture Fixation Technique |
| title_fullStr | Biomechanical Variability and Usability of a Novel Customizable Fracture Fixation Technique |
| title_full_unstemmed | Biomechanical Variability and Usability of a Novel Customizable Fracture Fixation Technique |
| title_short | Biomechanical Variability and Usability of a Novel Customizable Fracture Fixation Technique |
| title_sort | biomechanical variability and usability of a novel customizable fracture fixation technique |
| topic | in situ customizable osteosynthesis patient-specific osteosynthesis usability variability surgical skills |
| url | https://www.mdpi.com/2306-5354/10/10/1146 |
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