Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases
Due to ageing of the population, the incidence of cardiovascular diseases will increase in the coming years, constituting a substantial burden on health care systems. In particular, atrial fibrillation (AF) is approaching epidemic proportions. It has been identified that the derailment of proteostas...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/7/12/279 |
| _version_ | 1797723318070018048 |
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| author | Jin Li Deli Zhang Marit Wiersma Bianca J. J. M. Brundel |
| author_facet | Jin Li Deli Zhang Marit Wiersma Bianca J. J. M. Brundel |
| author_sort | Jin Li |
| collection | DOAJ |
| description | Due to ageing of the population, the incidence of cardiovascular diseases will increase in the coming years, constituting a substantial burden on health care systems. In particular, atrial fibrillation (AF) is approaching epidemic proportions. It has been identified that the derailment of proteostasis, which is characterized by the loss of homeostasis in protein biosynthesis, folding, trafficking, and clearance by protein degradation systems such as autophagy, underlies the development of common cardiac diseases. Among various safeguards within the proteostasis system, autophagy is a vital cellular process that modulates clearance of misfolded and proteotoxic proteins from cardiomyocytes. On the other hand, excessive autophagy may result in derailment of proteostasis and therefore cardiac dysfunction. Here, we review the interplay between autophagy and proteostasis in the healthy heart, discuss the imbalance between autophagy and proteostasis during cardiac diseases, including AF, and finally explore new druggable targets which may limit cardiac disease initiation and progression. |
| first_indexed | 2024-03-12T10:01:11Z |
| format | Article |
| id | doaj.art-30d77837ea874901a001e04b19952c46 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T10:01:11Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-30d77837ea874901a001e04b19952c462023-09-02T11:40:07ZengMDPI AGCells2073-44092018-12-0171227910.3390/cells7120279cells7120279Role of Autophagy in Proteostasis: Friend and Foe in Cardiac DiseasesJin Li0Deli Zhang1Marit Wiersma2Bianca J. J. M. Brundel3Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, 1081 HV Amsterdam, The NetherlandsDepartment of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, 1081 HV Amsterdam, The NetherlandsDepartment of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, 1081 HV Amsterdam, The NetherlandsDepartment of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, 1081 HV Amsterdam, The NetherlandsDue to ageing of the population, the incidence of cardiovascular diseases will increase in the coming years, constituting a substantial burden on health care systems. In particular, atrial fibrillation (AF) is approaching epidemic proportions. It has been identified that the derailment of proteostasis, which is characterized by the loss of homeostasis in protein biosynthesis, folding, trafficking, and clearance by protein degradation systems such as autophagy, underlies the development of common cardiac diseases. Among various safeguards within the proteostasis system, autophagy is a vital cellular process that modulates clearance of misfolded and proteotoxic proteins from cardiomyocytes. On the other hand, excessive autophagy may result in derailment of proteostasis and therefore cardiac dysfunction. Here, we review the interplay between autophagy and proteostasis in the healthy heart, discuss the imbalance between autophagy and proteostasis during cardiac diseases, including AF, and finally explore new druggable targets which may limit cardiac disease initiation and progression.https://www.mdpi.com/2073-4409/7/12/279proteostasisautophagycardiac diseaseatrial fibrillation |
| spellingShingle | Jin Li Deli Zhang Marit Wiersma Bianca J. J. M. Brundel Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases Cells proteostasis autophagy cardiac disease atrial fibrillation |
| title | Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases |
| title_full | Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases |
| title_fullStr | Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases |
| title_full_unstemmed | Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases |
| title_short | Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases |
| title_sort | role of autophagy in proteostasis friend and foe in cardiac diseases |
| topic | proteostasis autophagy cardiac disease atrial fibrillation |
| url | https://www.mdpi.com/2073-4409/7/12/279 |
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