Aucubin Impeded Preosteoclast Fusion and Enhanced CD31hi EMCNhi Vessel Angiogenesis in Ovariectomized Mice
Osteogenesis is tightly correlated with angiogenesis during the process of bone development, regeneration, and remodeling. In addition to providing nutrients and oxygen for bone tissue, blood vessels around bone tissue also secrete some factors to regulate bone formation. Type H vessels which were r...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2022-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2022/5226771 |
| _version_ | 1811179456178421760 |
|---|---|
| author | Ziyi Li Chang Liu Xiaoli Liu Na Wang Liu Gao Xiaoxue Bao Sijing Liu Peng Xue |
| author_facet | Ziyi Li Chang Liu Xiaoli Liu Na Wang Liu Gao Xiaoxue Bao Sijing Liu Peng Xue |
| author_sort | Ziyi Li |
| collection | DOAJ |
| description | Osteogenesis is tightly correlated with angiogenesis during the process of bone development, regeneration, and remodeling. In addition to providing nutrients and oxygen for bone tissue, blood vessels around bone tissue also secrete some factors to regulate bone formation. Type H vessels which were regulated by platelet-derived growth factor-BB (PDGF-BB) were confirmed to couple angiogenesis and osteogenesis. Recently, preosteoclasts have been identified as the most important source of PDGF-BB. Therefore, inhibiting osteoclast maturation, improving PDGF-BB secretion, stimulating type H angiogenesis, and subsequently accelerating bone regeneration may be potent treatments for bone loss disease. In the present study, aucubin, an iridoid glycoside extracted from Aucuba japonica and Eucommia ulmoides, was found to inhibit bone loss in ovariectomized mice. We further confirmed that aucubin could inhibit the fusion of tartrate-resistant acid phosphatase (TRAP)+ preosteoclasts into mature osteoclasts and indirectly increasing angiogenesis of type H vessel. The underlying mechanism is the aucubin-induced inhibition of MAPK/NF-κB signaling, which increases the preosteoclast number and subsequently promotes angiogenesis via PDGF-BB. These results prompted that aucubin could be an antiosteoporosis drug candidate, which needs further research. |
| first_indexed | 2024-04-11T06:35:45Z |
| format | Article |
| id | doaj.art-30d9189086d342179b834fd838d1301d |
| institution | Directory Open Access Journal |
| issn | 1687-9678 |
| language | English |
| last_indexed | 2024-04-11T06:35:45Z |
| publishDate | 2022-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj.art-30d9189086d342179b834fd838d1301d2022-12-22T04:39:50ZengHindawi LimitedStem Cells International1687-96782022-01-01202210.1155/2022/5226771Aucubin Impeded Preosteoclast Fusion and Enhanced CD31hi EMCNhi Vessel Angiogenesis in Ovariectomized MiceZiyi Li0Chang Liu1Xiaoli Liu2Na Wang3Liu Gao4Xiaoxue Bao5Sijing Liu6Peng Xue7Department of EndocrinologyDepartment of EndocrinologyDepartment of Pediatric DentistryDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyEditorial Department of Hebei Medical UniversityDepartment of EndocrinologyOsteogenesis is tightly correlated with angiogenesis during the process of bone development, regeneration, and remodeling. In addition to providing nutrients and oxygen for bone tissue, blood vessels around bone tissue also secrete some factors to regulate bone formation. Type H vessels which were regulated by platelet-derived growth factor-BB (PDGF-BB) were confirmed to couple angiogenesis and osteogenesis. Recently, preosteoclasts have been identified as the most important source of PDGF-BB. Therefore, inhibiting osteoclast maturation, improving PDGF-BB secretion, stimulating type H angiogenesis, and subsequently accelerating bone regeneration may be potent treatments for bone loss disease. In the present study, aucubin, an iridoid glycoside extracted from Aucuba japonica and Eucommia ulmoides, was found to inhibit bone loss in ovariectomized mice. We further confirmed that aucubin could inhibit the fusion of tartrate-resistant acid phosphatase (TRAP)+ preosteoclasts into mature osteoclasts and indirectly increasing angiogenesis of type H vessel. The underlying mechanism is the aucubin-induced inhibition of MAPK/NF-κB signaling, which increases the preosteoclast number and subsequently promotes angiogenesis via PDGF-BB. These results prompted that aucubin could be an antiosteoporosis drug candidate, which needs further research.http://dx.doi.org/10.1155/2022/5226771 |
| spellingShingle | Ziyi Li Chang Liu Xiaoli Liu Na Wang Liu Gao Xiaoxue Bao Sijing Liu Peng Xue Aucubin Impeded Preosteoclast Fusion and Enhanced CD31hi EMCNhi Vessel Angiogenesis in Ovariectomized Mice Stem Cells International |
| title | Aucubin Impeded Preosteoclast Fusion and Enhanced CD31hi EMCNhi Vessel Angiogenesis in Ovariectomized Mice |
| title_full | Aucubin Impeded Preosteoclast Fusion and Enhanced CD31hi EMCNhi Vessel Angiogenesis in Ovariectomized Mice |
| title_fullStr | Aucubin Impeded Preosteoclast Fusion and Enhanced CD31hi EMCNhi Vessel Angiogenesis in Ovariectomized Mice |
| title_full_unstemmed | Aucubin Impeded Preosteoclast Fusion and Enhanced CD31hi EMCNhi Vessel Angiogenesis in Ovariectomized Mice |
| title_short | Aucubin Impeded Preosteoclast Fusion and Enhanced CD31hi EMCNhi Vessel Angiogenesis in Ovariectomized Mice |
| title_sort | aucubin impeded preosteoclast fusion and enhanced cd31hi emcnhi vessel angiogenesis in ovariectomized mice |
| url | http://dx.doi.org/10.1155/2022/5226771 |
| work_keys_str_mv | AT ziyili aucubinimpededpreosteoclastfusionandenhancedcd31hiemcnhivesselangiogenesisinovariectomizedmice AT changliu aucubinimpededpreosteoclastfusionandenhancedcd31hiemcnhivesselangiogenesisinovariectomizedmice AT xiaoliliu aucubinimpededpreosteoclastfusionandenhancedcd31hiemcnhivesselangiogenesisinovariectomizedmice AT nawang aucubinimpededpreosteoclastfusionandenhancedcd31hiemcnhivesselangiogenesisinovariectomizedmice AT liugao aucubinimpededpreosteoclastfusionandenhancedcd31hiemcnhivesselangiogenesisinovariectomizedmice AT xiaoxuebao aucubinimpededpreosteoclastfusionandenhancedcd31hiemcnhivesselangiogenesisinovariectomizedmice AT sijingliu aucubinimpededpreosteoclastfusionandenhancedcd31hiemcnhivesselangiogenesisinovariectomizedmice AT pengxue aucubinimpededpreosteoclastfusionandenhancedcd31hiemcnhivesselangiogenesisinovariectomizedmice |