Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P

Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P

Abstract Selenium homeostasis depends on hepatic biosynthesis of selenoprotein P (SELENOP) and SELENOP-mediated transport from the liver to e.g. the brain. In addition, the liver maintains copper homeostasis. Selenium and copper metabolism are inversely regulated, as increasing copper and decreasing...

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Detalhes bibliográficos
Principais autores: Maria Schwarz, Caroline E. Meyer, Alina Löser, Kristina Lossow, Julian Hackler, Christiane Ott, Susanne Jäger, Isabelle Mohr, Ella A. Eklund, Angana A. H. Patel, Nadia Gul, Samantha Alvarez, Ilayda Altinonder, Clotilde Wiel, Maria Maares, Hajo Haase, Anetta Härtlova, Tilman Grune, Matthias B. Schulze, Tanja Schwerdtle, Uta Merle, Hans Zischka, Volkan I. Sayin, Lutz Schomburg, Anna P. Kipp
Formato: Artigo
Idioma:English
Publicado em: Nature Portfolio 2023-06-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-023-39245-3

Internet

https://doi.org/10.1038/s41467-023-39245-3

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