Respiratory Support of the Preterm Neonate: Lessons About Ventilation-Induced Brain Injury From Large Animal Models
Many preterm neonates require mechanical ventilation which increases the risk of cerebral inflammation and white matter injury in the immature brain. In this review, we discuss the links between ventilation and brain injury with a focus on the immediate period after birth, incorporating respiratory...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00862/full |
| _version_ | 1818037383489126400 |
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| author | Kyra Y. Y. Chan Kyra Y. Y. Chan Suzanne L. Miller Suzanne L. Miller Georg M. Schmölzer Georg M. Schmölzer Vanesa Stojanovska Vanesa Stojanovska Graeme R. Polglase Graeme R. Polglase |
| author_facet | Kyra Y. Y. Chan Kyra Y. Y. Chan Suzanne L. Miller Suzanne L. Miller Georg M. Schmölzer Georg M. Schmölzer Vanesa Stojanovska Vanesa Stojanovska Graeme R. Polglase Graeme R. Polglase |
| author_sort | Kyra Y. Y. Chan |
| collection | DOAJ |
| description | Many preterm neonates require mechanical ventilation which increases the risk of cerebral inflammation and white matter injury in the immature brain. In this review, we discuss the links between ventilation and brain injury with a focus on the immediate period after birth, incorporating respiratory support in the delivery room and subsequent mechanical ventilation in the neonatal intensive care unit. This review collates insight from large animal models in which acute injurious ventilation and prolonged periods of ventilation have been used to create clinically relevant brain injury patterns. These models are valuable resources in investigating the pathophysiology of ventilation-induced brain injury and have important translational implications. We discuss the challenges of reconciling lung and brain maturation in commonly used large animal models. A comprehensive understanding of ventilation-induced brain injury is necessary to guide the way we care for preterm neonates, with the goal to improve their neurodevelopmental outcomes. |
| first_indexed | 2024-12-10T07:25:58Z |
| format | Article |
| id | doaj.art-30da9fdd52e44833be2ced3ba4158fa2 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-10T07:25:58Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-30da9fdd52e44833be2ced3ba4158fa22022-12-22T01:57:41ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-08-011110.3389/fneur.2020.00862533707Respiratory Support of the Preterm Neonate: Lessons About Ventilation-Induced Brain Injury From Large Animal ModelsKyra Y. Y. Chan0Kyra Y. Y. Chan1Suzanne L. Miller2Suzanne L. Miller3Georg M. Schmölzer4Georg M. Schmölzer5Vanesa Stojanovska6Vanesa Stojanovska7Graeme R. Polglase8Graeme R. Polglase9The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, AustraliaDepartment of Obstetrics and Gynecology, Monash University, Clayton, VIC, AustraliaThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, AustraliaDepartment of Obstetrics and Gynecology, Monash University, Clayton, VIC, AustraliaNeonatal Research Unit, Centre for the Studies of Asphyxia and Resuscitation, Royal Alexandra Hospital, Edmonton, AB, CanadaDepartment of Pediatrics, University of Alberta, Edmonton, AB, CanadaThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, AustraliaDepartment of Obstetrics and Gynecology, Monash University, Clayton, VIC, AustraliaThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, AustraliaDepartment of Obstetrics and Gynecology, Monash University, Clayton, VIC, AustraliaMany preterm neonates require mechanical ventilation which increases the risk of cerebral inflammation and white matter injury in the immature brain. In this review, we discuss the links between ventilation and brain injury with a focus on the immediate period after birth, incorporating respiratory support in the delivery room and subsequent mechanical ventilation in the neonatal intensive care unit. This review collates insight from large animal models in which acute injurious ventilation and prolonged periods of ventilation have been used to create clinically relevant brain injury patterns. These models are valuable resources in investigating the pathophysiology of ventilation-induced brain injury and have important translational implications. We discuss the challenges of reconciling lung and brain maturation in commonly used large animal models. A comprehensive understanding of ventilation-induced brain injury is necessary to guide the way we care for preterm neonates, with the goal to improve their neurodevelopmental outcomes.https://www.frontiersin.org/article/10.3389/fneur.2020.00862/fullventilationrespiratory supportventilation-induced brain injuryneurodevelopmentpreterm |
| spellingShingle | Kyra Y. Y. Chan Kyra Y. Y. Chan Suzanne L. Miller Suzanne L. Miller Georg M. Schmölzer Georg M. Schmölzer Vanesa Stojanovska Vanesa Stojanovska Graeme R. Polglase Graeme R. Polglase Respiratory Support of the Preterm Neonate: Lessons About Ventilation-Induced Brain Injury From Large Animal Models Frontiers in Neurology ventilation respiratory support ventilation-induced brain injury neurodevelopment preterm |
| title | Respiratory Support of the Preterm Neonate: Lessons About Ventilation-Induced Brain Injury From Large Animal Models |
| title_full | Respiratory Support of the Preterm Neonate: Lessons About Ventilation-Induced Brain Injury From Large Animal Models |
| title_fullStr | Respiratory Support of the Preterm Neonate: Lessons About Ventilation-Induced Brain Injury From Large Animal Models |
| title_full_unstemmed | Respiratory Support of the Preterm Neonate: Lessons About Ventilation-Induced Brain Injury From Large Animal Models |
| title_short | Respiratory Support of the Preterm Neonate: Lessons About Ventilation-Induced Brain Injury From Large Animal Models |
| title_sort | respiratory support of the preterm neonate lessons about ventilation induced brain injury from large animal models |
| topic | ventilation respiratory support ventilation-induced brain injury neurodevelopment preterm |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00862/full |
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