An Evaluation of the Clinical Efficacy of Tomato Extract for Perennial Allergic Rhinitis
Background: Recently, some common foods in daily life have been found to have anti-allergic effects. We have reported that tomato extract (TE) could possibly inhibit histamine release and mouse ear-swelling responses. Moreover, it is reported that TE could relieve the symptoms for Japanese cedar pol...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2007-01-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015308698 |
| _version_ | 1811205096840626176 |
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| author | Mineka Yoshimura Tadao Enomoto Yoshihiro Dake Yoshiaki Okuno Hiroki Ikeda Lei Cheng Akio Obata |
| author_facet | Mineka Yoshimura Tadao Enomoto Yoshihiro Dake Yoshiaki Okuno Hiroki Ikeda Lei Cheng Akio Obata |
| author_sort | Mineka Yoshimura |
| collection | DOAJ |
| description | Background: Recently, some common foods in daily life have been found to have anti-allergic effects. We have reported that tomato extract (TE) could possibly inhibit histamine release and mouse ear-swelling responses. Moreover, it is reported that TE could relieve the symptoms for Japanese cedar pollinosis.
Methods: To evaluate the anti-allergic effect of TE, we performed a randomized, double-blind, placebo-controlled study in 33 patients with perennial allergic rhinitis (PAR) using oral administration of TE (360 mg per day) or placebo for 8 weeks.
Results: We found that the sneezing score significantly decreased in the TE group at the end of the trial compared to the beginning (P < 0.05). There were decreasing tendencies of rhinorrhea and nasal obstruction in the TE group. The patients’ quality of life was significantly improved in the TE group after 8 weeks of treatment (P < 0.05), but not in placebo group. A significant improvement in total symptom scores, combining sneezing, rhinorrhea and nasal obstruction, was observed after oral administration of TE for 8 weeks (P < 0.01). The safety of TE treatment was confirmed by laboratory tests and inspection of general conditions.
Conclusions: TE can be expected to safely improve the nasal symptoms of PAR. |
| first_indexed | 2024-04-12T03:25:52Z |
| format | Article |
| id | doaj.art-30dcf46142ca40fa86e80f43d797360f |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-04-12T03:25:52Z |
| publishDate | 2007-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-30dcf46142ca40fa86e80f43d797360f2022-12-22T03:49:43ZengElsevierAllergology International1323-89302007-01-0156322523010.2332/allergolint.O-06-443An Evaluation of the Clinical Efficacy of Tomato Extract for Perennial Allergic RhinitisMineka Yoshimura0Tadao Enomoto1Yoshihiro Dake2Yoshiaki Okuno3Hiroki Ikeda4Lei Cheng5Akio Obata6Research & Development Division, Kikkoman Corporation, Chiba,Department of Otolaryngology, Japanese Red Cross Society Wakayama Medical Center,Dake ENT Clinic, Wakayama,Okuno ENT Clinic, Osaka, Japan,Department of Otolaryngology, Japanese Red Cross Society Wakayama Medical Center,International Research Centre for Nasal Allergy, Nanjing Medical University and Department of Otorhinolaryngology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Research & Development Division, Kikkoman Corporation, Chiba,Background: Recently, some common foods in daily life have been found to have anti-allergic effects. We have reported that tomato extract (TE) could possibly inhibit histamine release and mouse ear-swelling responses. Moreover, it is reported that TE could relieve the symptoms for Japanese cedar pollinosis. Methods: To evaluate the anti-allergic effect of TE, we performed a randomized, double-blind, placebo-controlled study in 33 patients with perennial allergic rhinitis (PAR) using oral administration of TE (360 mg per day) or placebo for 8 weeks. Results: We found that the sneezing score significantly decreased in the TE group at the end of the trial compared to the beginning (P < 0.05). There were decreasing tendencies of rhinorrhea and nasal obstruction in the TE group. The patients’ quality of life was significantly improved in the TE group after 8 weeks of treatment (P < 0.05), but not in placebo group. A significant improvement in total symptom scores, combining sneezing, rhinorrhea and nasal obstruction, was observed after oral administration of TE for 8 weeks (P < 0.01). The safety of TE treatment was confirmed by laboratory tests and inspection of general conditions. Conclusions: TE can be expected to safely improve the nasal symptoms of PAR.http://www.sciencedirect.com/science/article/pii/S1323893015308698clinical efficacyeosinophilshistamine releaseperennial allergic rhinitistomato extract |
| spellingShingle | Mineka Yoshimura Tadao Enomoto Yoshihiro Dake Yoshiaki Okuno Hiroki Ikeda Lei Cheng Akio Obata An Evaluation of the Clinical Efficacy of Tomato Extract for Perennial Allergic Rhinitis Allergology International clinical efficacy eosinophils histamine release perennial allergic rhinitis tomato extract |
| title | An Evaluation of the Clinical Efficacy of Tomato Extract for Perennial Allergic Rhinitis |
| title_full | An Evaluation of the Clinical Efficacy of Tomato Extract for Perennial Allergic Rhinitis |
| title_fullStr | An Evaluation of the Clinical Efficacy of Tomato Extract for Perennial Allergic Rhinitis |
| title_full_unstemmed | An Evaluation of the Clinical Efficacy of Tomato Extract for Perennial Allergic Rhinitis |
| title_short | An Evaluation of the Clinical Efficacy of Tomato Extract for Perennial Allergic Rhinitis |
| title_sort | evaluation of the clinical efficacy of tomato extract for perennial allergic rhinitis |
| topic | clinical efficacy eosinophils histamine release perennial allergic rhinitis tomato extract |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015308698 |
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