The efficacy of Jujube syrup on the prevention of drug‐induced hepatotoxicity in pulmonary tuberculosis patients: A pilot randomized double‐blind placebo‐controlled clinical trial
Abstract Liver injury is the most common complication of anti‐tuberculosis drugs that can cause significant problems. The study aimed to determine the effectiveness of Jujube syrup on the prevention of antituberculosis drug‐induced hepatotoxicity (DIH). This pilot randomized double‐blind study was c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-02-01
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| Series: | Pharmacology Research & Perspectives |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/prp2.902 |
| _version_ | 1828892022406119424 |
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| author | Seyedeh Zahra Maddahi Assie Jokar Mohammad Kamalinejad Nasser Behnampur |
| author_facet | Seyedeh Zahra Maddahi Assie Jokar Mohammad Kamalinejad Nasser Behnampur |
| author_sort | Seyedeh Zahra Maddahi |
| collection | DOAJ |
| description | Abstract Liver injury is the most common complication of anti‐tuberculosis drugs that can cause significant problems. The study aimed to determine the effectiveness of Jujube syrup on the prevention of antituberculosis drug‐induced hepatotoxicity (DIH). This pilot randomized double‐blind study was conducted based on a placebo‐controlled design in patients with tuberculosis (TB). The patients were divided into two groups based on the block random allocation method and received 10 cc of jujube or placebo syrup per day. The liver enzyme levels were assessed as primary outcomes, and the severity of cough, anorexia, and nausea along with the quality of life (QOL) was assessed as secondary outcomes. Finally, eight and nine patients in the jujube and placebo groups completed the study, respectively. In the second week of the study, 27.3% of the patients in the placebo group developed hepatotoxicity. Moreover, there was no liver toxicity in the jujube group. This difference between the two groups was statistically significant (p = .037). Furthermore, the severity of cough in patients in the jujube group decreased significantly during weeks 2 and 4. The QOL significantly improved in the jujube group, compared to the placebo group. This study suggested that Jujube syrup could prevent anti‐TB DIH. It can also improve the severity of cough and the QOL in pulmonary TB patients. |
| first_indexed | 2024-12-13T13:28:20Z |
| format | Article |
| id | doaj.art-30df8461cfe04e80a1487d39f49e2bd3 |
| institution | Directory Open Access Journal |
| issn | 2052-1707 |
| language | English |
| last_indexed | 2024-12-13T13:28:20Z |
| publishDate | 2022-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pharmacology Research & Perspectives |
| spelling | doaj.art-30df8461cfe04e80a1487d39f49e2bd32022-12-21T23:44:14ZengWileyPharmacology Research & Perspectives2052-17072022-02-01101n/an/a10.1002/prp2.902The efficacy of Jujube syrup on the prevention of drug‐induced hepatotoxicity in pulmonary tuberculosis patients: A pilot randomized double‐blind placebo‐controlled clinical trialSeyedeh Zahra Maddahi0Assie Jokar1Mohammad Kamalinejad2Nasser Behnampur3Persian Medicine Student Research Committee Mazandaran University of Medical Sciences Sari IranFaculty of Medicine Department of Persian Medicine Mazandaran University of Medical Sciences Sari IranSchool of Pharmacy Shahid Beheshti University of Medical Sciences Tehran IranDepartment of Biostatistics Health Management and Social Development Research Center Golestan University of Medical Sciences Gorgan IranAbstract Liver injury is the most common complication of anti‐tuberculosis drugs that can cause significant problems. The study aimed to determine the effectiveness of Jujube syrup on the prevention of antituberculosis drug‐induced hepatotoxicity (DIH). This pilot randomized double‐blind study was conducted based on a placebo‐controlled design in patients with tuberculosis (TB). The patients were divided into two groups based on the block random allocation method and received 10 cc of jujube or placebo syrup per day. The liver enzyme levels were assessed as primary outcomes, and the severity of cough, anorexia, and nausea along with the quality of life (QOL) was assessed as secondary outcomes. Finally, eight and nine patients in the jujube and placebo groups completed the study, respectively. In the second week of the study, 27.3% of the patients in the placebo group developed hepatotoxicity. Moreover, there was no liver toxicity in the jujube group. This difference between the two groups was statistically significant (p = .037). Furthermore, the severity of cough in patients in the jujube group decreased significantly during weeks 2 and 4. The QOL significantly improved in the jujube group, compared to the placebo group. This study suggested that Jujube syrup could prevent anti‐TB DIH. It can also improve the severity of cough and the QOL in pulmonary TB patients.https://doi.org/10.1002/prp2.902antioxidantdrug‐induced hepatotoxicityJujubetraditional Persian medicinetuberculosis |
| spellingShingle | Seyedeh Zahra Maddahi Assie Jokar Mohammad Kamalinejad Nasser Behnampur The efficacy of Jujube syrup on the prevention of drug‐induced hepatotoxicity in pulmonary tuberculosis patients: A pilot randomized double‐blind placebo‐controlled clinical trial Pharmacology Research & Perspectives antioxidant drug‐induced hepatotoxicity Jujube traditional Persian medicine tuberculosis |
| title | The efficacy of Jujube syrup on the prevention of drug‐induced hepatotoxicity in pulmonary tuberculosis patients: A pilot randomized double‐blind placebo‐controlled clinical trial |
| title_full | The efficacy of Jujube syrup on the prevention of drug‐induced hepatotoxicity in pulmonary tuberculosis patients: A pilot randomized double‐blind placebo‐controlled clinical trial |
| title_fullStr | The efficacy of Jujube syrup on the prevention of drug‐induced hepatotoxicity in pulmonary tuberculosis patients: A pilot randomized double‐blind placebo‐controlled clinical trial |
| title_full_unstemmed | The efficacy of Jujube syrup on the prevention of drug‐induced hepatotoxicity in pulmonary tuberculosis patients: A pilot randomized double‐blind placebo‐controlled clinical trial |
| title_short | The efficacy of Jujube syrup on the prevention of drug‐induced hepatotoxicity in pulmonary tuberculosis patients: A pilot randomized double‐blind placebo‐controlled clinical trial |
| title_sort | efficacy of jujube syrup on the prevention of drug induced hepatotoxicity in pulmonary tuberculosis patients a pilot randomized double blind placebo controlled clinical trial |
| topic | antioxidant drug‐induced hepatotoxicity Jujube traditional Persian medicine tuberculosis |
| url | https://doi.org/10.1002/prp2.902 |
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