A cost/benefit analysis of clinical trial designs for COVID-19 vaccine candidates.

A cost/benefit analysis of clinical trial designs for COVID-19 vaccine candidates.

We compare and contrast the expected duration and number of infections and deaths averted among several designs for clinical trials of COVID-19 vaccine candidates, including traditional and adaptive randomized clinical trials and human challenge trials. Using epidemiological models calibrated to the...

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Bibliographic Details
Main Authors: Donald A Berry, Scott Berry, Peter Hale, Leah Isakov, Andrew W Lo, Kien Wei Siah, Chi Heem Wong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0244418

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