Exercise to transform tumours from cold to hot and improve immunotherapy responsiveness
Exercise provides significant health benefits to patients diagnosed with cancer including improved survival outcomes, quality of life and reduced cancer recurrence. Across multiple murine cancer models, aerobic exercise and resistance training has exhibited anti-tumour properties illustrated by inhi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1335256/full |
| _version_ | 1797393387014324224 |
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| author | Brindley Hapuarachi Brindley Hapuarachi Sarah Danson Sarah Danson Jon Wadsley Munitta Muthana |
| author_facet | Brindley Hapuarachi Brindley Hapuarachi Sarah Danson Sarah Danson Jon Wadsley Munitta Muthana |
| author_sort | Brindley Hapuarachi |
| collection | DOAJ |
| description | Exercise provides significant health benefits to patients diagnosed with cancer including improved survival outcomes, quality of life and reduced cancer recurrence. Across multiple murine cancer models, aerobic exercise and resistance training has exhibited anti-tumour properties illustrated by inhibited tumour growth, reduced metastatic potential and modulation of the tumour microenvironment to allow the recognition and destruction of cancer cells. Clinical studies have demonstrated the rapid mobilisation and circulatory release of mature lymphoid populations, myokines and cytokines that occurs with exercise along with tumour vasculature normalisation. Tumour microenvironments enriched with immune cells with anti-cancer potential, such as CD8+ T cells, are termed ‘hot’, whilst those favouring an immunosuppressive environment and lacking in effector immune cells are classed as ‘cold’. Pre-clinical evidence suggests exercise training has the potential to reprogramme cold tumours to become hot, although this requires validation in clinical studies. This hot environment could potentiate immunotherapy responsiveness, improving survival outcomes of patients undergoing cancer immunotherapy and allow those with typically cold tumours to benefit from immunotherapy. This review discusses the complex interactions between exercise and cancer, including exercise-induced alterations within the tumour microenvironment and systemic immunity. The potential role exercise may play in improving cancer immunotherapy responsiveness is explored. This review also highlights the need for translational studies exploring the role of exercise in patients with cancer with the potential to widen the spectrum of tumours that derive significant benefit from immunotherapy. |
| first_indexed | 2024-03-09T00:02:46Z |
| format | Article |
| id | doaj.art-30e8590c42174459a5a98a62e50b742f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-09T00:02:46Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-30e8590c42174459a5a98a62e50b742f2023-12-12T14:40:42ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-12-011410.3389/fimmu.2023.13352561335256Exercise to transform tumours from cold to hot and improve immunotherapy responsivenessBrindley Hapuarachi0Brindley Hapuarachi1Sarah Danson2Sarah Danson3Jon Wadsley4Munitta Muthana5University Sheffield, Division of Clinical Medicine, Sheffield, United KingdomWeston Park Cancer Centre, Sheffield Teaching Hospitals National Health Service (NHS) Foundation Trust, Sheffield, United KingdomUniversity Sheffield, Division of Clinical Medicine, Sheffield, United KingdomWeston Park Cancer Centre, Sheffield Teaching Hospitals National Health Service (NHS) Foundation Trust, Sheffield, United KingdomWeston Park Cancer Centre, Sheffield Teaching Hospitals National Health Service (NHS) Foundation Trust, Sheffield, United KingdomUniversity Sheffield, Division of Clinical Medicine, Sheffield, United KingdomExercise provides significant health benefits to patients diagnosed with cancer including improved survival outcomes, quality of life and reduced cancer recurrence. Across multiple murine cancer models, aerobic exercise and resistance training has exhibited anti-tumour properties illustrated by inhibited tumour growth, reduced metastatic potential and modulation of the tumour microenvironment to allow the recognition and destruction of cancer cells. Clinical studies have demonstrated the rapid mobilisation and circulatory release of mature lymphoid populations, myokines and cytokines that occurs with exercise along with tumour vasculature normalisation. Tumour microenvironments enriched with immune cells with anti-cancer potential, such as CD8+ T cells, are termed ‘hot’, whilst those favouring an immunosuppressive environment and lacking in effector immune cells are classed as ‘cold’. Pre-clinical evidence suggests exercise training has the potential to reprogramme cold tumours to become hot, although this requires validation in clinical studies. This hot environment could potentiate immunotherapy responsiveness, improving survival outcomes of patients undergoing cancer immunotherapy and allow those with typically cold tumours to benefit from immunotherapy. This review discusses the complex interactions between exercise and cancer, including exercise-induced alterations within the tumour microenvironment and systemic immunity. The potential role exercise may play in improving cancer immunotherapy responsiveness is explored. This review also highlights the need for translational studies exploring the role of exercise in patients with cancer with the potential to widen the spectrum of tumours that derive significant benefit from immunotherapy.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1335256/fullexercisetumourimmunitymicroenvironmentimmunotherapyhot |
| spellingShingle | Brindley Hapuarachi Brindley Hapuarachi Sarah Danson Sarah Danson Jon Wadsley Munitta Muthana Exercise to transform tumours from cold to hot and improve immunotherapy responsiveness Frontiers in Immunology exercise tumour immunity microenvironment immunotherapy hot |
| title | Exercise to transform tumours from cold to hot and improve immunotherapy responsiveness |
| title_full | Exercise to transform tumours from cold to hot and improve immunotherapy responsiveness |
| title_fullStr | Exercise to transform tumours from cold to hot and improve immunotherapy responsiveness |
| title_full_unstemmed | Exercise to transform tumours from cold to hot and improve immunotherapy responsiveness |
| title_short | Exercise to transform tumours from cold to hot and improve immunotherapy responsiveness |
| title_sort | exercise to transform tumours from cold to hot and improve immunotherapy responsiveness |
| topic | exercise tumour immunity microenvironment immunotherapy hot |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1335256/full |
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