A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic
Hydrogels with adhesive properties have the potential for rapid haemostasis and wound healing in uncontrolled non-pressurized surface bleeding. Herein, a typical hydrogen bond-crosslinked hydrogel with the above functions was constructed by directly mixing solutions of humic acid (HA) and polyvinylp...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.855013/full |
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| author | Han Yu Han Yu Han Yu Qiaohong Xiao Guilin Qi Feixiang Chen Biyue Tu Suo Zhang Yinping Li Yun Chen Hui Yu Peng Duan |
| author_facet | Han Yu Han Yu Han Yu Qiaohong Xiao Guilin Qi Feixiang Chen Biyue Tu Suo Zhang Yinping Li Yun Chen Hui Yu Peng Duan |
| author_sort | Han Yu |
| collection | DOAJ |
| description | Hydrogels with adhesive properties have the potential for rapid haemostasis and wound healing in uncontrolled non-pressurized surface bleeding. Herein, a typical hydrogen bond-crosslinked hydrogel with the above functions was constructed by directly mixing solutions of humic acid (HA) and polyvinylpyrrolidone (PVP), in which the HA worked as a crosslinking agent to form hydrogen bonds with the PVP. By altering the concentration of HA, a cluster of stable and uniform hydrogels were prepared within 10 s. The dynamic and reversible nature of the hydrogen bonds gave the HA/PVP complex (HPC) hydrogels injectability and good flexibility, as well as a self-healing ability. Moreover, the numerous functional groups in the hydrogels enhanced the cohesion strength and interaction on the interface between the hydrogel and the substrate, endowing them with good adhesion properties. The unique chemical composition and cross-linking mechanism gave the HPC hydrogel good biocompatibility. Taking advantage of all these features, the HPC hydrogels obtained in this work were broadly applied as haemostatic agents and showed a good therapeutic effect. This work might lead to an improvement in the development of multifunctional non-covalent hydrogels for application to biomaterials. |
| first_indexed | 2024-12-12T22:27:28Z |
| format | Article |
| id | doaj.art-30e9a6d4ad9b435bb0ec3e7f5ecf43c6 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-12T22:27:28Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-30e9a6d4ad9b435bb0ec3e7f5ecf43c62022-12-22T00:09:42ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-04-011010.3389/fbioe.2022.855013855013A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for HemostaticHan Yu0Han Yu1Han Yu2Qiaohong Xiao3Guilin Qi4Feixiang Chen5Biyue Tu6Suo Zhang7Yinping Li8Yun Chen9Hui Yu10Peng Duan11Department of Pathology, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, ChinaKey Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Xiangyang City, Department of Obstetrics and Gynaecology, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, ChinaDepartment of Pathophysiology and Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, ChinaKey Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Xiangyang City, Department of Obstetrics and Gynaecology, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, ChinaKey Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Xiangyang City, Department of Obstetrics and Gynaecology, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, ChinaDepartment of Biomedical Engineering and Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, ChinaFourth Clinical College, Hubei University of Medicine, Shiyan, ChinaFourth Clinical College, Hubei University of Medicine, Shiyan, ChinaDepartment of Pathophysiology and Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, ChinaDepartment of Biomedical Engineering and Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, ChinaKey Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Xiangyang City, Department of Obstetrics and Gynaecology, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, ChinaKey Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Xiangyang City, Department of Obstetrics and Gynaecology, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, ChinaHydrogels with adhesive properties have the potential for rapid haemostasis and wound healing in uncontrolled non-pressurized surface bleeding. Herein, a typical hydrogen bond-crosslinked hydrogel with the above functions was constructed by directly mixing solutions of humic acid (HA) and polyvinylpyrrolidone (PVP), in which the HA worked as a crosslinking agent to form hydrogen bonds with the PVP. By altering the concentration of HA, a cluster of stable and uniform hydrogels were prepared within 10 s. The dynamic and reversible nature of the hydrogen bonds gave the HA/PVP complex (HPC) hydrogels injectability and good flexibility, as well as a self-healing ability. Moreover, the numerous functional groups in the hydrogels enhanced the cohesion strength and interaction on the interface between the hydrogel and the substrate, endowing them with good adhesion properties. The unique chemical composition and cross-linking mechanism gave the HPC hydrogel good biocompatibility. Taking advantage of all these features, the HPC hydrogels obtained in this work were broadly applied as haemostatic agents and showed a good therapeutic effect. This work might lead to an improvement in the development of multifunctional non-covalent hydrogels for application to biomaterials.https://www.frontiersin.org/articles/10.3389/fbioe.2022.855013/fullhydrogelhydrogen bondadhesiveself-healinghemostatic |
| spellingShingle | Han Yu Han Yu Han Yu Qiaohong Xiao Guilin Qi Feixiang Chen Biyue Tu Suo Zhang Yinping Li Yun Chen Hui Yu Peng Duan A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic Frontiers in Bioengineering and Biotechnology hydrogel hydrogen bond adhesive self-healing hemostatic |
| title | A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic |
| title_full | A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic |
| title_fullStr | A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic |
| title_full_unstemmed | A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic |
| title_short | A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic |
| title_sort | hydrogen bonds crosslinked hydrogels with self healing and adhesive properties for hemostatic |
| topic | hydrogel hydrogen bond adhesive self-healing hemostatic |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.855013/full |
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