Monoterpenoid Glycosides from the Leaves of <i>Ligustrum robustum</i> and Their Bioactivities (II)
<i>Ligustrum robustum</i> has been not only used as a heat-clearing and detoxicating functional tea (Ku-Ding-Cha) but also consumed as a hypotensive, anti-diabetic, and weight-reducing folk medicine. From the leaves of <i>L. robustum</i>, ten new monoterpenoid glycosides name...
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MDPI AG
2023-10-01
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| Online Access: | https://www.mdpi.com/1420-3049/28/21/7274 |
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| author | Shi-Hui Lu Xiu-Xia Li Hao-Jiang Zuo Wei-Neng Li Jia-Ping Pan Jing Huang |
| author_facet | Shi-Hui Lu Xiu-Xia Li Hao-Jiang Zuo Wei-Neng Li Jia-Ping Pan Jing Huang |
| author_sort | Shi-Hui Lu |
| collection | DOAJ |
| description | <i>Ligustrum robustum</i> has been not only used as a heat-clearing and detoxicating functional tea (Ku-Ding-Cha) but also consumed as a hypotensive, anti-diabetic, and weight-reducing folk medicine. From the leaves of <i>L. robustum</i>, ten new monoterpenoid glycosides named ligurobustosides T<sub>10</sub> (<b>1a</b>), T<sub>11</sub> (<b>1b</b>), T<sub>12</sub> (<b>2a</b>), T<sub>13</sub> (<b>2b</b>), T<sub>14</sub> (<b>3a</b>), T<sub>15</sub> (<b>3b</b>), F<sub>1</sub> (<b>4b</b>), T<sub>16</sub> (<b>5a</b>), T<sub>17</sub> (<b>5b</b>), and E<sub>1</sub> (<b>6b</b>), together with five known ones (<b>4a</b>, <b>6a</b>, <b>7</b>, <b>8a</b>, <b>8b</b>), were separated and identified using the spectroscopic method and chemical method in this research. The results of biological tests exhibited that the fatty acid synthase (FAS) inhibitory action of compound <b>5</b> (IC<sub>50</sub>: 4.38 ± 0.11 μM) was as strong as orlistat (IC<sub>50</sub>: 4.46 ± 0.13 μM), a positive control; the α-glucosidase inhibitory actions of compounds <b>1</b>–<b>4</b> and <b>7</b>–<b>8</b>, and the α-amylase inhibitory actions of compounds <b>1</b>–<b>8</b> were medium; the ABTS radical scavenging capacities of compounds <b>1</b>–<b>3</b> and <b>5</b>–<b>8</b> (IC<sub>50</sub>: 6.27 ± 0.23 ~ 8.59 ± 0.09 μM) were stronger than <span style="font-variant: small-caps;">l</span>-(+)-ascorbic acid (IC<sub>50</sub>: 10.06 ± 0.19 μM) served as a positive control. This research offered a theoretical foundation for the leaves of <i>L. robustum</i> to prevent diabetes and its complications. |
| first_indexed | 2024-03-11T11:25:07Z |
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| language | English |
| last_indexed | 2024-03-11T11:25:07Z |
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| spelling | doaj.art-30ea53230c6a439aa55bbed5c336a82b2023-11-10T15:08:27ZengMDPI AGMolecules1420-30492023-10-012821727410.3390/molecules28217274Monoterpenoid Glycosides from the Leaves of <i>Ligustrum robustum</i> and Their Bioactivities (II)Shi-Hui Lu0Xiu-Xia Li1Hao-Jiang Zuo2Wei-Neng Li3Jia-Ping Pan4Jing Huang5College of Pharmacy, Youjiang Medical University for Nationalities, Baise 533000, ChinaNursing School, Youjiang Medical University for Nationalities, Baise 533000, ChinaDepartment of Laboratory Science of Public Health, West China School of Public Health, Sichuan University, Chengdu 610041, ChinaCollege of Pharmacy, Youjiang Medical University for Nationalities, Baise 533000, ChinaCollege of Pharmacy, Youjiang Medical University for Nationalities, Baise 533000, ChinaKey Laboratory of Drug Targeting, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China<i>Ligustrum robustum</i> has been not only used as a heat-clearing and detoxicating functional tea (Ku-Ding-Cha) but also consumed as a hypotensive, anti-diabetic, and weight-reducing folk medicine. From the leaves of <i>L. robustum</i>, ten new monoterpenoid glycosides named ligurobustosides T<sub>10</sub> (<b>1a</b>), T<sub>11</sub> (<b>1b</b>), T<sub>12</sub> (<b>2a</b>), T<sub>13</sub> (<b>2b</b>), T<sub>14</sub> (<b>3a</b>), T<sub>15</sub> (<b>3b</b>), F<sub>1</sub> (<b>4b</b>), T<sub>16</sub> (<b>5a</b>), T<sub>17</sub> (<b>5b</b>), and E<sub>1</sub> (<b>6b</b>), together with five known ones (<b>4a</b>, <b>6a</b>, <b>7</b>, <b>8a</b>, <b>8b</b>), were separated and identified using the spectroscopic method and chemical method in this research. The results of biological tests exhibited that the fatty acid synthase (FAS) inhibitory action of compound <b>5</b> (IC<sub>50</sub>: 4.38 ± 0.11 μM) was as strong as orlistat (IC<sub>50</sub>: 4.46 ± 0.13 μM), a positive control; the α-glucosidase inhibitory actions of compounds <b>1</b>–<b>4</b> and <b>7</b>–<b>8</b>, and the α-amylase inhibitory actions of compounds <b>1</b>–<b>8</b> were medium; the ABTS radical scavenging capacities of compounds <b>1</b>–<b>3</b> and <b>5</b>–<b>8</b> (IC<sub>50</sub>: 6.27 ± 0.23 ~ 8.59 ± 0.09 μM) were stronger than <span style="font-variant: small-caps;">l</span>-(+)-ascorbic acid (IC<sub>50</sub>: 10.06 ± 0.19 μM) served as a positive control. This research offered a theoretical foundation for the leaves of <i>L. robustum</i> to prevent diabetes and its complications.https://www.mdpi.com/1420-3049/28/21/7274<i>Ligustrum robustum</i>monoterpenoid glycosideFASα-glucosidaseantioxidantanti-diabetes |
| spellingShingle | Shi-Hui Lu Xiu-Xia Li Hao-Jiang Zuo Wei-Neng Li Jia-Ping Pan Jing Huang Monoterpenoid Glycosides from the Leaves of <i>Ligustrum robustum</i> and Their Bioactivities (II) Molecules <i>Ligustrum robustum</i> monoterpenoid glycoside FAS α-glucosidase antioxidant anti-diabetes |
| title | Monoterpenoid Glycosides from the Leaves of <i>Ligustrum robustum</i> and Their Bioactivities (II) |
| title_full | Monoterpenoid Glycosides from the Leaves of <i>Ligustrum robustum</i> and Their Bioactivities (II) |
| title_fullStr | Monoterpenoid Glycosides from the Leaves of <i>Ligustrum robustum</i> and Their Bioactivities (II) |
| title_full_unstemmed | Monoterpenoid Glycosides from the Leaves of <i>Ligustrum robustum</i> and Their Bioactivities (II) |
| title_short | Monoterpenoid Glycosides from the Leaves of <i>Ligustrum robustum</i> and Their Bioactivities (II) |
| title_sort | monoterpenoid glycosides from the leaves of i ligustrum robustum i and their bioactivities ii |
| topic | <i>Ligustrum robustum</i> monoterpenoid glycoside FAS α-glucosidase antioxidant anti-diabetes |
| url | https://www.mdpi.com/1420-3049/28/21/7274 |
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