Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs

Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs

Thymus-originated tTregs and in vitro induced iTregs are subsets of regulatory T cells. While they share the capacity of immune suppression, their stabilities are different, with iTregs losing their phenotype upon stimulation or under inflammatory milieu. Epigenetic differences, particularly methyla...

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Bibliographic Details
Main Authors: Huiyun Lyu, Guohua Yuan, Xinyi Liu, Xiaobo Wang, Shuang Geng, Tie Xia, Xuyu Zhou, Yinqing Li, Xiaoyu Hu, Yan Shi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-12-01
Series:eLife
Subjects:
Treg
stability
calcium signal
NFAT
chromatin accessibility
iTreg
Online Access:https://elifesciences.org/articles/88874

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