Modeling human influenza infection in the laboratory
Kathryn A Radigan,1 Alexander V Misharin,2 Monica Chi,1 GR Scott Budinger11Division of Pulmonary and Critical Care Medicine, 2Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USAAbstract: Influenza is the leading cause of death from an infectious cause. Bec...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2015-08-01
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| Series: | Infection and Drug Resistance |
| Online Access: | http://www.dovepress.com/modeling-human-influenza-infection-in-the-laboratory-peer-reviewed-article-IDR |
| _version_ | 1811266211069034496 |
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| author | Radigan KA Misharin AV Chi M Scott Budinger GR |
| author_facet | Radigan KA Misharin AV Chi M Scott Budinger GR |
| author_sort | Radigan KA |
| collection | DOAJ |
| description | Kathryn A Radigan,1 Alexander V Misharin,2 Monica Chi,1 GR Scott Budinger11Division of Pulmonary and Critical Care Medicine, 2Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USAAbstract: Influenza is the leading cause of death from an infectious cause. Because of its clinical importance, many investigators use animal models to understand the biologic mechanisms of influenza A virus replication, the immune response to the virus, and the efficacy of novel therapies. This review will focus on the biosafety, biosecurity, and ethical concerns that must be considered in pursuing influenza research, in addition to focusing on the two animal models – mice and ferrets – most frequently used by researchers as models of human influenza infection.Keywords: mice, ferret, influenza, animal model, biosafety |
| first_indexed | 2024-04-12T20:38:06Z |
| format | Article |
| id | doaj.art-30eca2c6c36a48c8874ca34c11ab8ee3 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-12T20:38:06Z |
| publishDate | 2015-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-30eca2c6c36a48c8874ca34c11ab8ee32022-12-22T03:17:30ZengDove Medical PressInfection and Drug Resistance1178-69732015-08-012015default31132023450Modeling human influenza infection in the laboratoryRadigan KAMisharin AVChi MScott Budinger GRKathryn A Radigan,1 Alexander V Misharin,2 Monica Chi,1 GR Scott Budinger11Division of Pulmonary and Critical Care Medicine, 2Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USAAbstract: Influenza is the leading cause of death from an infectious cause. Because of its clinical importance, many investigators use animal models to understand the biologic mechanisms of influenza A virus replication, the immune response to the virus, and the efficacy of novel therapies. This review will focus on the biosafety, biosecurity, and ethical concerns that must be considered in pursuing influenza research, in addition to focusing on the two animal models – mice and ferrets – most frequently used by researchers as models of human influenza infection.Keywords: mice, ferret, influenza, animal model, biosafetyhttp://www.dovepress.com/modeling-human-influenza-infection-in-the-laboratory-peer-reviewed-article-IDR |
| spellingShingle | Radigan KA Misharin AV Chi M Scott Budinger GR Modeling human influenza infection in the laboratory Infection and Drug Resistance |
| title | Modeling human influenza infection in the laboratory |
| title_full | Modeling human influenza infection in the laboratory |
| title_fullStr | Modeling human influenza infection in the laboratory |
| title_full_unstemmed | Modeling human influenza infection in the laboratory |
| title_short | Modeling human influenza infection in the laboratory |
| title_sort | modeling human influenza infection in the laboratory |
| url | http://www.dovepress.com/modeling-human-influenza-infection-in-the-laboratory-peer-reviewed-article-IDR |
| work_keys_str_mv | AT radiganka modelinghumaninfluenzainfectioninthelaboratory AT misharinav modelinghumaninfluenzainfectioninthelaboratory AT chim modelinghumaninfluenzainfectioninthelaboratory AT scottbudingergr modelinghumaninfluenzainfectioninthelaboratory |