Current pathophysiological concepts in Cerebral Small Vessel Disease
The association between cerebral small vessel disease (SVD) – in the form of white matter lesions, infarctions, and hemorrhages – with vascular cognitive impairment (VCI), has mostly been deduced from observational studies. Pathological conditions affecting the small vessels of the brain and leading...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-03-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00024/full |
| _version_ | 1818108715917639680 |
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| author | Fred eRincon Clinton eWright |
| author_facet | Fred eRincon Clinton eWright |
| author_sort | Fred eRincon |
| collection | DOAJ |
| description | The association between cerebral small vessel disease (SVD) – in the form of white matter lesions, infarctions, and hemorrhages – with vascular cognitive impairment (VCI), has mostly been deduced from observational studies. Pathological conditions affecting the small vessels of the brain and leading to SVD have suggested plausible molecular mechanisms involved in vascular damage and their impact on brain function. However, much still needs to be clarified in understanding the pathophysiology of VCI, the role of neurodegenerative processes such as Alzheimer disease, and the impact of aging itself. In addition, both genetic predispositions and environmental exposures may potentiate the development of SVD and interact with normal aging to impact cognitive function and require further study. Advances in technology, in the analysis of genetic and epigenetic data, neuroimaging such as MRI, and new biomarkers will help to clarify the complex factors leading to SVD and the expression of VCI. |
| first_indexed | 2024-12-11T02:19:46Z |
| format | Article |
| id | doaj.art-30ee94dcb138443193e0dcb928638727 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-11T02:19:46Z |
| publishDate | 2014-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-30ee94dcb138443193e0dcb9286387272022-12-22T01:24:05ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652014-03-01610.3389/fnagi.2014.0002466050Current pathophysiological concepts in Cerebral Small Vessel DiseaseFred eRincon0Clinton eWright1Thomas Jefferson UniversityUniversity of MiamiThe association between cerebral small vessel disease (SVD) – in the form of white matter lesions, infarctions, and hemorrhages – with vascular cognitive impairment (VCI), has mostly been deduced from observational studies. Pathological conditions affecting the small vessels of the brain and leading to SVD have suggested plausible molecular mechanisms involved in vascular damage and their impact on brain function. However, much still needs to be clarified in understanding the pathophysiology of VCI, the role of neurodegenerative processes such as Alzheimer disease, and the impact of aging itself. In addition, both genetic predispositions and environmental exposures may potentiate the development of SVD and interact with normal aging to impact cognitive function and require further study. Advances in technology, in the analysis of genetic and epigenetic data, neuroimaging such as MRI, and new biomarkers will help to clarify the complex factors leading to SVD and the expression of VCI.http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00024/fullAlzheimer DiseaseLeukoaraiosisStrokevascular cognitive impairmentsilent brain infarction |
| spellingShingle | Fred eRincon Clinton eWright Current pathophysiological concepts in Cerebral Small Vessel Disease Frontiers in Aging Neuroscience Alzheimer Disease Leukoaraiosis Stroke vascular cognitive impairment silent brain infarction |
| title | Current pathophysiological concepts in Cerebral Small Vessel Disease |
| title_full | Current pathophysiological concepts in Cerebral Small Vessel Disease |
| title_fullStr | Current pathophysiological concepts in Cerebral Small Vessel Disease |
| title_full_unstemmed | Current pathophysiological concepts in Cerebral Small Vessel Disease |
| title_short | Current pathophysiological concepts in Cerebral Small Vessel Disease |
| title_sort | current pathophysiological concepts in cerebral small vessel disease |
| topic | Alzheimer Disease Leukoaraiosis Stroke vascular cognitive impairment silent brain infarction |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00024/full |
| work_keys_str_mv | AT frederincon currentpathophysiologicalconceptsincerebralsmallvesseldisease AT clintonewright currentpathophysiologicalconceptsincerebralsmallvesseldisease |