Platybasia in 22q11.2 Deletion Syndrome Is Not Correlated with Speech Resonance
Background An abnormally obtuse cranial base angle, also known as platybasia, is a common finding in patients with 22q11.2 deletion syndrome (22q11DS). Platybasia increases the depth of the velopharynx and is therefore postulated to contribute to velopharyngeal dysfunction. Our objective was to det...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2014-07-01
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| Series: | Archives of Plastic Surgery |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2014.41.4.344 |
| _version_ | 1798037700013457408 |
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| author | Nicole E Spruijt Moshe Kon Aebele B Mink van der Molen |
| author_facet | Nicole E Spruijt Moshe Kon Aebele B Mink van der Molen |
| author_sort | Nicole E Spruijt |
| collection | DOAJ |
| description | Background An abnormally obtuse cranial base angle, also known as platybasia, is a common finding in patients with 22q11.2 deletion syndrome (22q11DS). Platybasia increases the depth of the velopharynx and is therefore postulated to contribute to velopharyngeal dysfunction. Our objective was to determine the clinical significance of platybasia in 22q11DS by exploring the relationship between cranial base angles and speech resonance.
Methods In this retrospective chart review at a tertiary hospital, 24 children (age, 4.0-13.1 years) with 22q11.2DS underwent speech assessments and lateral cephalograms, which allowed for the measurement of the cranial base angles.
Results One patient (4%) had hyponasal resonance, 8 (33%) had normal resonance, 10 (42%) had hypernasal resonance on vowels only, and 5 (21%) had hypernasal resonance on both vowels and consonants. The mean cranial base angle was 136.5° (standard deviation, 5.3°; range, 122.3-144.8°). The Kruskal-Wallis test showed no significant relationship between the resonance ratings and cranial base angles (P=0.242). Cranial base angles and speech ratings were not correlated (Spearman correlation=0.321, P=0.126). The group with hypernasal resonance had a significantly more obtuse mean cranial base angle (138° vs. 134°, P=0.049) but did not have a greater prevalence of platybasia (73% vs. 56%, P=0.412).
Conclusions In this retrospective chart review of patients with 22q11DS, cranial base angles were not correlated with speech resonance. The clinical significance of platybasia remains unknown. |
| first_indexed | 2024-04-11T21:30:06Z |
| format | Article |
| id | doaj.art-30eead4bf37449938b4c4e3246006178 |
| institution | Directory Open Access Journal |
| issn | 2234-6163 2234-6171 |
| language | English |
| last_indexed | 2024-04-11T21:30:06Z |
| publishDate | 2014-07-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | Archives of Plastic Surgery |
| spelling | doaj.art-30eead4bf37449938b4c4e32460061782022-12-22T04:02:01ZengThieme Medical Publishers, Inc.Archives of Plastic Surgery2234-61632234-61712014-07-01410434434910.5999/aps.2014.41.4.344356Platybasia in 22q11.2 Deletion Syndrome Is Not Correlated with Speech ResonanceNicole E Spruijt0Moshe Kon1Aebele B Mink van der Molen2Department of Plastic Surgery, University Medical Center, Utrecht, The NetherlandsDepartment of Plastic Surgery, University Medical Center, Utrecht, The NetherlandsDepartment of Plastic Surgery, University Medical Center, Utrecht, The NetherlandsBackground An abnormally obtuse cranial base angle, also known as platybasia, is a common finding in patients with 22q11.2 deletion syndrome (22q11DS). Platybasia increases the depth of the velopharynx and is therefore postulated to contribute to velopharyngeal dysfunction. Our objective was to determine the clinical significance of platybasia in 22q11DS by exploring the relationship between cranial base angles and speech resonance. Methods In this retrospective chart review at a tertiary hospital, 24 children (age, 4.0-13.1 years) with 22q11.2DS underwent speech assessments and lateral cephalograms, which allowed for the measurement of the cranial base angles. Results One patient (4%) had hyponasal resonance, 8 (33%) had normal resonance, 10 (42%) had hypernasal resonance on vowels only, and 5 (21%) had hypernasal resonance on both vowels and consonants. The mean cranial base angle was 136.5° (standard deviation, 5.3°; range, 122.3-144.8°). The Kruskal-Wallis test showed no significant relationship between the resonance ratings and cranial base angles (P=0.242). Cranial base angles and speech ratings were not correlated (Spearman correlation=0.321, P=0.126). The group with hypernasal resonance had a significantly more obtuse mean cranial base angle (138° vs. 134°, P=0.049) but did not have a greater prevalence of platybasia (73% vs. 56%, P=0.412). Conclusions In this retrospective chart review of patients with 22q11DS, cranial base angles were not correlated with speech resonance. The clinical significance of platybasia remains unknown.http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2014.41.4.344digeorge syndromeplatybasiavelopharyngeal insufficiency |
| spellingShingle | Nicole E Spruijt Moshe Kon Aebele B Mink van der Molen Platybasia in 22q11.2 Deletion Syndrome Is Not Correlated with Speech Resonance Archives of Plastic Surgery digeorge syndrome platybasia velopharyngeal insufficiency |
| title | Platybasia in 22q11.2 Deletion Syndrome Is Not Correlated with Speech Resonance |
| title_full | Platybasia in 22q11.2 Deletion Syndrome Is Not Correlated with Speech Resonance |
| title_fullStr | Platybasia in 22q11.2 Deletion Syndrome Is Not Correlated with Speech Resonance |
| title_full_unstemmed | Platybasia in 22q11.2 Deletion Syndrome Is Not Correlated with Speech Resonance |
| title_short | Platybasia in 22q11.2 Deletion Syndrome Is Not Correlated with Speech Resonance |
| title_sort | platybasia in 22q11 2 deletion syndrome is not correlated with speech resonance |
| topic | digeorge syndrome platybasia velopharyngeal insufficiency |
| url | http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2014.41.4.344 |
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