Exposure to traffic noise and air pollution and risk for febrile seizure: a cohort study
OBJECTIVES: Exposure to traffic noise and air pollution is suspected to increase susceptibility to viral infections – the main triggering factor for febrile seizures. No studies have examined these two exposures in relation to febrile seizures. We aimed to investigate whether exposure to road traffi...
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| Format: | Article |
| Language: | English |
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Nordic Association of Occupational Safety and Health (NOROSH)
2018-09-01
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| Series: | Scandinavian Journal of Work, Environment & Health |
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| Online Access: |
https://www.sjweh.fi/show_abstract.php?abstract_id=3724
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| _version_ | 1819296473582403584 |
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| author | Dorrit Hjortebjerg Anne-Marie Nybo Andersen Matthias Ketzel Ole Raaschou-Nielsen Mette Sørensen |
| author_facet | Dorrit Hjortebjerg Anne-Marie Nybo Andersen Matthias Ketzel Ole Raaschou-Nielsen Mette Sørensen |
| author_sort | Dorrit Hjortebjerg |
| collection | DOAJ |
| description | OBJECTIVES: Exposure to traffic noise and air pollution is suspected to increase susceptibility to viral infections – the main triggering factor for febrile seizures. No studies have examined these two exposures in relation to febrile seizures. We aimed to investigate whether exposure to road traffic noise and air pollution are associated with risk of febrile seizures in childhood. METHODS: From our study base of 51 465 singletons from a national birth cohort, we identified 2175 cases with febrile seizures using a nationwide registry. Residential address history from conception to six years of age were found in national registers, and road traffic noise (L_den) and air pollution (NO_2) were modeled for all addresses. Analyses were done using Cox proportional hazard model with adjustment for potential confounders, including mutual exposure adjustment. RESULTS: An interquartile range (IQR) increase in childhood exposure to road traffic noise and air pollution was associated with an 11% [incidence rate ratio (IRR) 1.11, 95% confidence interval (CI) 1.04–1.19) and 5% (IRR 1.05, 95% CI 1.02–1.07) higher risk for febrile seizures, respectively, after adjustment for potential confounders. Weaker tendencies were seen for pregnancy exposure. In models with mutual exposure adjustment, the estimates were slightly lower, with IRR of 1.08 (95% CI 1.00–1.16) and 1.03 (95% CI 0.99–1.06) per IQR increase in childhood exposure to road traffic noise and air pollution, respectively. CONCLUSIONS: This study suggests that residential exposure to road traffic noise and air pollution is associated with higher risk for febrile seizures. |
| first_indexed | 2024-12-24T04:58:40Z |
| format | Article |
| id | doaj.art-30efc2e361c249439071ee34e7a6daf1 |
| institution | Directory Open Access Journal |
| issn | 0355-3140 1795-990X |
| language | English |
| last_indexed | 2024-12-24T04:58:40Z |
| publishDate | 2018-09-01 |
| publisher | Nordic Association of Occupational Safety and Health (NOROSH) |
| record_format | Article |
| series | Scandinavian Journal of Work, Environment & Health |
| spelling | doaj.art-30efc2e361c249439071ee34e7a6daf12022-12-21T17:14:18ZengNordic Association of Occupational Safety and Health (NOROSH)Scandinavian Journal of Work, Environment & Health0355-31401795-990X2018-09-0144553954610.5271/sjweh.37243724Exposure to traffic noise and air pollution and risk for febrile seizure: a cohort studyDorrit Hjortebjerg0Anne-Marie Nybo AndersenMatthias KetzelOle Raaschou-NielsenMette SørensenDanish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen Ø, Denmark.OBJECTIVES: Exposure to traffic noise and air pollution is suspected to increase susceptibility to viral infections – the main triggering factor for febrile seizures. No studies have examined these two exposures in relation to febrile seizures. We aimed to investigate whether exposure to road traffic noise and air pollution are associated with risk of febrile seizures in childhood. METHODS: From our study base of 51 465 singletons from a national birth cohort, we identified 2175 cases with febrile seizures using a nationwide registry. Residential address history from conception to six years of age were found in national registers, and road traffic noise (L_den) and air pollution (NO_2) were modeled for all addresses. Analyses were done using Cox proportional hazard model with adjustment for potential confounders, including mutual exposure adjustment. RESULTS: An interquartile range (IQR) increase in childhood exposure to road traffic noise and air pollution was associated with an 11% [incidence rate ratio (IRR) 1.11, 95% confidence interval (CI) 1.04–1.19) and 5% (IRR 1.05, 95% CI 1.02–1.07) higher risk for febrile seizures, respectively, after adjustment for potential confounders. Weaker tendencies were seen for pregnancy exposure. In models with mutual exposure adjustment, the estimates were slightly lower, with IRR of 1.08 (95% CI 1.00–1.16) and 1.03 (95% CI 0.99–1.06) per IQR increase in childhood exposure to road traffic noise and air pollution, respectively. CONCLUSIONS: This study suggests that residential exposure to road traffic noise and air pollution is associated with higher risk for febrile seizures. https://www.sjweh.fi/show_abstract.php?abstract_id=3724 exposurecohort studynoiseair pollutiontraffic noisefebrile seizure |
| spellingShingle | Dorrit Hjortebjerg Anne-Marie Nybo Andersen Matthias Ketzel Ole Raaschou-Nielsen Mette Sørensen Exposure to traffic noise and air pollution and risk for febrile seizure: a cohort study Scandinavian Journal of Work, Environment & Health exposure cohort study noise air pollution traffic noise febrile seizure |
| title | Exposure to traffic noise and air pollution and risk for febrile seizure: a cohort study |
| title_full | Exposure to traffic noise and air pollution and risk for febrile seizure: a cohort study |
| title_fullStr | Exposure to traffic noise and air pollution and risk for febrile seizure: a cohort study |
| title_full_unstemmed | Exposure to traffic noise and air pollution and risk for febrile seizure: a cohort study |
| title_short | Exposure to traffic noise and air pollution and risk for febrile seizure: a cohort study |
| title_sort | exposure to traffic noise and air pollution and risk for febrile seizure a cohort study |
| topic | exposure cohort study noise air pollution traffic noise febrile seizure |
| url |
https://www.sjweh.fi/show_abstract.php?abstract_id=3724
|
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