Post-operative N-terminal pro-brain natriuretic peptide predicts in-hospital mortality after living donor liver transplantation
Objective: The post-operative serum level of N-terminal pro-brain natriuretic peptide (NT-proBNP) has been found to be associated with post-operative cardiovascular complications and mortality in high-risk surgeries. The usefulness of the post-operative NT-proBNP level as a predictor of mortality af...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KARE Publishing
2020-06-01
|
| Series: | Türk Kardiyoloji Derneği Arşivi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-42637 |
| _version_ | 1797907005365551104 |
|---|---|
| author | İsmail Polat Canbolat Cansu Akdeniz Oya Ferah Yaman Tokat |
| author_facet | İsmail Polat Canbolat Cansu Akdeniz Oya Ferah Yaman Tokat |
| author_sort | İsmail Polat Canbolat |
| collection | DOAJ |
| description | Objective: The post-operative serum level of N-terminal pro-brain natriuretic peptide (NT-proBNP) has been found to be associated with post-operative cardiovascular complications and mortality in high-risk surgeries. The usefulness of the post-operative NT-proBNP level as a predictor of mortality after liver transplantation (LT) is unknown.
Methods: The records of patients at a single, tertiary university hospital who had undergone adult living donor liver transplantation (LDLT) with data of post-operative NT-proBNP level values were retrospectively analyzed for in-hospital mortality. The highest post-operative NT-proBNP level from the first 3 days after surgery was included in the study. Receiver operating characteristic curve analysis was performed to assess the best cut-off value of post-operative NT-proBNP, and Cox regression analysis was performed to investigate the effect of NT-proBNP on mortality.
Results: A total of 114 LT recipients with a mean Model for End-Stage Liver Disease score of 15.8 were included in the study. In-hospital mortality occurred in 11 (9.6%) of the patients. A history of diabetes mellitus and the post-operative NT-proBNP level were found to be associated with mortality (p=0.011 for diabetes mellitus and p<0.001 for NT-proBNP). The best cut-off value of post-operative NT-proBNP was 1009 ng/L. Cox regression analysis indicated that the NT-proBNP level was a strong predictor of in-hospital mortality (hazard ratio: 24.467, 95% confidence interval: 3.120–191.750; p=0.002).
Conclusion: The post-operative NT-proBNP serum level independently predicted in-hospital mortality in patients who underwent LDLT. Post-operative NT-proBNP-guided management of LT recipients should be pursued. |
| first_indexed | 2024-04-10T10:29:40Z |
| format | Article |
| id | doaj.art-30efc697d7df47b6b6d28fbfe5aa2b68 |
| institution | Directory Open Access Journal |
| issn | 1016-5169 |
| language | English |
| last_indexed | 2024-04-10T10:29:40Z |
| publishDate | 2020-06-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Türk Kardiyoloji Derneği Arşivi |
| spelling | doaj.art-30efc697d7df47b6b6d28fbfe5aa2b682023-02-15T16:21:10ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692020-06-0148437437910.5543/tkda.2020.42637TKDA-42637Post-operative N-terminal pro-brain natriuretic peptide predicts in-hospital mortality after living donor liver transplantationİsmail Polat Canbolat0Cansu Akdeniz1Oya Ferah2Yaman Tokat3Department of Cardiology, Demiroğlu Bilim University Faculty of Medicine, İstanbul, TurkeyDepartment of Cardiology, Demiroğlu Bilim University Faculty of Medicine, İstanbul, TurkeyDepartment of Anesthesiology and Reanimation, Demiroğlu Bilim University Faculty of Medicine, İstanbul, TurkeyCenter of Liver Transplantation, Şişli Florence Nightingale Hospital, İstanbul, TurkeyObjective: The post-operative serum level of N-terminal pro-brain natriuretic peptide (NT-proBNP) has been found to be associated with post-operative cardiovascular complications and mortality in high-risk surgeries. The usefulness of the post-operative NT-proBNP level as a predictor of mortality after liver transplantation (LT) is unknown. Methods: The records of patients at a single, tertiary university hospital who had undergone adult living donor liver transplantation (LDLT) with data of post-operative NT-proBNP level values were retrospectively analyzed for in-hospital mortality. The highest post-operative NT-proBNP level from the first 3 days after surgery was included in the study. Receiver operating characteristic curve analysis was performed to assess the best cut-off value of post-operative NT-proBNP, and Cox regression analysis was performed to investigate the effect of NT-proBNP on mortality. Results: A total of 114 LT recipients with a mean Model for End-Stage Liver Disease score of 15.8 were included in the study. In-hospital mortality occurred in 11 (9.6%) of the patients. A history of diabetes mellitus and the post-operative NT-proBNP level were found to be associated with mortality (p=0.011 for diabetes mellitus and p<0.001 for NT-proBNP). The best cut-off value of post-operative NT-proBNP was 1009 ng/L. Cox regression analysis indicated that the NT-proBNP level was a strong predictor of in-hospital mortality (hazard ratio: 24.467, 95% confidence interval: 3.120–191.750; p=0.002). Conclusion: The post-operative NT-proBNP serum level independently predicted in-hospital mortality in patients who underwent LDLT. Post-operative NT-proBNP-guided management of LT recipients should be pursued.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-42637in-hospital mortalityliving donor liver transplantation; nt-probnp. |
| spellingShingle | İsmail Polat Canbolat Cansu Akdeniz Oya Ferah Yaman Tokat Post-operative N-terminal pro-brain natriuretic peptide predicts in-hospital mortality after living donor liver transplantation Türk Kardiyoloji Derneği Arşivi in-hospital mortality living donor liver transplantation; nt-probnp. |
| title | Post-operative N-terminal pro-brain natriuretic peptide predicts in-hospital mortality after living donor liver transplantation |
| title_full | Post-operative N-terminal pro-brain natriuretic peptide predicts in-hospital mortality after living donor liver transplantation |
| title_fullStr | Post-operative N-terminal pro-brain natriuretic peptide predicts in-hospital mortality after living donor liver transplantation |
| title_full_unstemmed | Post-operative N-terminal pro-brain natriuretic peptide predicts in-hospital mortality after living donor liver transplantation |
| title_short | Post-operative N-terminal pro-brain natriuretic peptide predicts in-hospital mortality after living donor liver transplantation |
| title_sort | post operative n terminal pro brain natriuretic peptide predicts in hospital mortality after living donor liver transplantation |
| topic | in-hospital mortality living donor liver transplantation; nt-probnp. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-42637 |
| work_keys_str_mv | AT ismailpolatcanbolat postoperativenterminalprobrainnatriureticpeptidepredictsinhospitalmortalityafterlivingdonorlivertransplantation AT cansuakdeniz postoperativenterminalprobrainnatriureticpeptidepredictsinhospitalmortalityafterlivingdonorlivertransplantation AT oyaferah postoperativenterminalprobrainnatriureticpeptidepredictsinhospitalmortalityafterlivingdonorlivertransplantation AT yamantokat postoperativenterminalprobrainnatriureticpeptidepredictsinhospitalmortalityafterlivingdonorlivertransplantation |