Spatial cognition and memory: a reversible lesion with lidocaine into the anteromedial/posterior parietal cortex (AM/PPC) affects differently working and long-term memory on two foraging tasks
Place memory is relevant for exploration and forage behaviour. When food supply is dispersed, a win-shift has advantage over a win-stay strategy. In the Olton Octagonal Maze, the rat follows a win-shift strategy using working memory. However, in the Olton 4x4 version, the rat follows a win-stay stra...
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| Format: | Article |
| Language: | English |
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BMC
2006-01-01
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| Series: | Biological Research |
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| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000500003 |
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| author | PABLO ESPINA-MARCHANT TERESA PINTO-HAMUY DIEGO BUSTAMANTE PAOLA MORALES LUIS ROBLES MARIO HERRERA-MARSCHITZ |
| author_facet | PABLO ESPINA-MARCHANT TERESA PINTO-HAMUY DIEGO BUSTAMANTE PAOLA MORALES LUIS ROBLES MARIO HERRERA-MARSCHITZ |
| author_sort | PABLO ESPINA-MARCHANT |
| collection | DOAJ |
| description | Place memory is relevant for exploration and forage behaviour. When food supply is dispersed, a win-shift has advantage over a win-stay strategy. In the Olton Octagonal Maze, the rat follows a win-shift strategy using working memory. However, in the Olton 4x4 version, the rat follows a win-stay strategy, using both working and long-term memories. It has been suggested that the neocortex is required for the resolution of tasks demanding long-term, but not for that demanding working memory alone. The role of anteromedial/posterior parietal cortex (AM/PPC) was investigated here, using a reversible lesion induced by intracerebral lidocaine infusion. Long-Evans rats were implanted with guide cannulae into the AM/PPC and trained in an Olton 4x4 maze, counting working and long-term memory errors after a delay. Then, the animals were infused with lidocaine or saline during the delay phase and tested for three days. Another series of animals, treated as before, was tested in an Olton Octagonal Maze and subjected to the same injection schedule. In the Olton 4x4 Maze, lidocaine produced a significant increase in working and long-term memory errors, compared to saline and post-lidocaine conditions. In contrast, in the Olton Octagonal Maze, lidocaine did not induce any effect on working memory errors. Thus, AM/PPC is required when both working with previous information and long-term memories are needed, but not when only working memory is required, as it happens under ethological conditions. Whenever food supply is dispersed, a win-shift strategy is preferable |
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| format | Article |
| id | doaj.art-30f30de781984169a15c846609b857d5 |
| institution | Directory Open Access Journal |
| issn | 0716-9760 0717-6287 |
| language | English |
| last_indexed | 2024-12-20T19:33:47Z |
| publishDate | 2006-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Research |
| spelling | doaj.art-30f30de781984169a15c846609b857d52022-12-21T19:28:43ZengBMCBiological Research0716-97600717-62872006-01-01394601609Spatial cognition and memory: a reversible lesion with lidocaine into the anteromedial/posterior parietal cortex (AM/PPC) affects differently working and long-term memory on two foraging tasksPABLO ESPINA-MARCHANTTERESA PINTO-HAMUYDIEGO BUSTAMANTEPAOLA MORALESLUIS ROBLESMARIO HERRERA-MARSCHITZPlace memory is relevant for exploration and forage behaviour. When food supply is dispersed, a win-shift has advantage over a win-stay strategy. In the Olton Octagonal Maze, the rat follows a win-shift strategy using working memory. However, in the Olton 4x4 version, the rat follows a win-stay strategy, using both working and long-term memories. It has been suggested that the neocortex is required for the resolution of tasks demanding long-term, but not for that demanding working memory alone. The role of anteromedial/posterior parietal cortex (AM/PPC) was investigated here, using a reversible lesion induced by intracerebral lidocaine infusion. Long-Evans rats were implanted with guide cannulae into the AM/PPC and trained in an Olton 4x4 maze, counting working and long-term memory errors after a delay. Then, the animals were infused with lidocaine or saline during the delay phase and tested for three days. Another series of animals, treated as before, was tested in an Olton Octagonal Maze and subjected to the same injection schedule. In the Olton 4x4 Maze, lidocaine produced a significant increase in working and long-term memory errors, compared to saline and post-lidocaine conditions. In contrast, in the Olton Octagonal Maze, lidocaine did not induce any effect on working memory errors. Thus, AM/PPC is required when both working with previous information and long-term memories are needed, but not when only working memory is required, as it happens under ethological conditions. Whenever food supply is dispersed, a win-shift strategy is preferablehttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000500003Anteromedial/posterior parietal cortexhippocampuslidocaine, long-term memoryworking memoryintracerebral infusionrat |
| spellingShingle | PABLO ESPINA-MARCHANT TERESA PINTO-HAMUY DIEGO BUSTAMANTE PAOLA MORALES LUIS ROBLES MARIO HERRERA-MARSCHITZ Spatial cognition and memory: a reversible lesion with lidocaine into the anteromedial/posterior parietal cortex (AM/PPC) affects differently working and long-term memory on two foraging tasks Biological Research Anteromedial/posterior parietal cortex hippocampus lidocaine, long-term memory working memory intracerebral infusion rat |
| title | Spatial cognition and memory: a reversible lesion with lidocaine into the anteromedial/posterior parietal cortex (AM/PPC) affects differently working and long-term memory on two foraging tasks |
| title_full | Spatial cognition and memory: a reversible lesion with lidocaine into the anteromedial/posterior parietal cortex (AM/PPC) affects differently working and long-term memory on two foraging tasks |
| title_fullStr | Spatial cognition and memory: a reversible lesion with lidocaine into the anteromedial/posterior parietal cortex (AM/PPC) affects differently working and long-term memory on two foraging tasks |
| title_full_unstemmed | Spatial cognition and memory: a reversible lesion with lidocaine into the anteromedial/posterior parietal cortex (AM/PPC) affects differently working and long-term memory on two foraging tasks |
| title_short | Spatial cognition and memory: a reversible lesion with lidocaine into the anteromedial/posterior parietal cortex (AM/PPC) affects differently working and long-term memory on two foraging tasks |
| title_sort | spatial cognition and memory a reversible lesion with lidocaine into the anteromedial posterior parietal cortex am ppc affects differently working and long term memory on two foraging tasks |
| topic | Anteromedial/posterior parietal cortex hippocampus lidocaine, long-term memory working memory intracerebral infusion rat |
| url | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000500003 |
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