Polyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed Indians
Abstract Detailed characterisation of immune responses induced by COVID-19 vaccines rolled out in India: COVISHIELDTM (CS) and COVAXIN® (CO) in a pre-exposed population is only recently being discovered. We addressed this issue in subjects who received their primary series of vaccination between Nov...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-09-01
|
| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-023-00731-w |
| _version_ | 1797578310422626304 |
|---|---|
| author | Srabanti Rakshit Sudhir Babji Chaitra Parthiban Ramya Madhavan Vasista Adiga Sharon Eveline J Nirutha Chetan Kumar Asma Ahmed Sudarshan Shivalingaiah Nandini Shashikumar Mamatha V Avita Rose Johnson Naveen Ramesh Ramkrishna Goud B Mangaiarkarasi Asokan Satyajit Mayor Gagandeep Kang George D’souza Mary Dias Annapurna Vyakarnam |
| author_facet | Srabanti Rakshit Sudhir Babji Chaitra Parthiban Ramya Madhavan Vasista Adiga Sharon Eveline J Nirutha Chetan Kumar Asma Ahmed Sudarshan Shivalingaiah Nandini Shashikumar Mamatha V Avita Rose Johnson Naveen Ramesh Ramkrishna Goud B Mangaiarkarasi Asokan Satyajit Mayor Gagandeep Kang George D’souza Mary Dias Annapurna Vyakarnam |
| author_sort | Srabanti Rakshit |
| collection | DOAJ |
| description | Abstract Detailed characterisation of immune responses induced by COVID-19 vaccines rolled out in India: COVISHIELDTM (CS) and COVAXIN® (CO) in a pre-exposed population is only recently being discovered. We addressed this issue in subjects who received their primary series of vaccination between November 2021 and January 2022. Both vaccines are capable of strongly boosting Wuhan Spike-specific neutralising antibody, polyfunctional Th1 cytokine producing CD4+ T-cells and single IFN-γ + CD8+ T-cells. Consistent with inherent differences in vaccine platform, the vector-based CS vaccine-induced immunity was of greater magnitude, breadth, targeting Delta and Omicron variants compared to the whole-virion inactivated vaccine CO, with CS vaccinees showing persistent CD8+ T-cells responses until 3 months post primary vaccination. This study provides detailed evidence on the magnitude and quality of CS and CO vaccine induced responses in subjects with pre-existing SARS-CoV-2 immunity in India, thereby mitigating vaccine hesitancy arguments in such a population, which remains a global health challenge. |
| first_indexed | 2024-03-10T22:20:07Z |
| format | Article |
| id | doaj.art-30f5306b692f49f4b2a280fbe4ebd644 |
| institution | Directory Open Access Journal |
| issn | 2059-0105 |
| language | English |
| last_indexed | 2024-03-10T22:20:07Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj.art-30f5306b692f49f4b2a280fbe4ebd6442023-11-19T12:18:00ZengNature Portfolionpj Vaccines2059-01052023-09-018111810.1038/s41541-023-00731-wPolyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed IndiansSrabanti Rakshit0Sudhir Babji1Chaitra Parthiban2Ramya Madhavan3Vasista Adiga4Sharon Eveline J5Nirutha Chetan Kumar6Asma Ahmed7Sudarshan Shivalingaiah8Nandini Shashikumar9Mamatha V10Avita Rose Johnson11Naveen Ramesh12Ramkrishna Goud B13Mangaiarkarasi Asokan14Satyajit Mayor15Gagandeep Kang16George D’souza17Mary Dias18Annapurna Vyakarnam19Division of Infectious Diseases, St. John’s Research InstituteThe Wellcome Trust Research Laboratory, Christian Medical CollegeDivision of Infectious Diseases, St. John’s Research InstituteThe Wellcome Trust Research Laboratory, Christian Medical CollegeDivision of Infectious Diseases, St. John’s Research InstituteDivision of Infectious Diseases, St. John’s Research InstituteDivision of Infectious Diseases, St. John’s Research InstituteDivision of Infectious Diseases, St. John’s Research InstituteDivision of Infectious Diseases, St. John’s Research InstituteDivision of Infectious Diseases, St. John’s Research InstituteSt. John’s Medical CollegeSt. John’s Medical CollegeSt. John’s Medical CollegeSt. John’s Medical CollegeNational Centre for Biological SciencesNational Centre for Biological SciencesThe Wellcome Trust Research Laboratory, Christian Medical CollegeDepartment of Pulmonary Medicine, St. John’s Medical CollegeDivision of Infectious Diseases, St. John’s Research InstituteDivision of Infectious Diseases, St. John’s Research InstituteAbstract Detailed characterisation of immune responses induced by COVID-19 vaccines rolled out in India: COVISHIELDTM (CS) and COVAXIN® (CO) in a pre-exposed population is only recently being discovered. We addressed this issue in subjects who received their primary series of vaccination between November 2021 and January 2022. Both vaccines are capable of strongly boosting Wuhan Spike-specific neutralising antibody, polyfunctional Th1 cytokine producing CD4+ T-cells and single IFN-γ + CD8+ T-cells. Consistent with inherent differences in vaccine platform, the vector-based CS vaccine-induced immunity was of greater magnitude, breadth, targeting Delta and Omicron variants compared to the whole-virion inactivated vaccine CO, with CS vaccinees showing persistent CD8+ T-cells responses until 3 months post primary vaccination. This study provides detailed evidence on the magnitude and quality of CS and CO vaccine induced responses in subjects with pre-existing SARS-CoV-2 immunity in India, thereby mitigating vaccine hesitancy arguments in such a population, which remains a global health challenge.https://doi.org/10.1038/s41541-023-00731-w |
| spellingShingle | Srabanti Rakshit Sudhir Babji Chaitra Parthiban Ramya Madhavan Vasista Adiga Sharon Eveline J Nirutha Chetan Kumar Asma Ahmed Sudarshan Shivalingaiah Nandini Shashikumar Mamatha V Avita Rose Johnson Naveen Ramesh Ramkrishna Goud B Mangaiarkarasi Asokan Satyajit Mayor Gagandeep Kang George D’souza Mary Dias Annapurna Vyakarnam Polyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed Indians npj Vaccines |
| title | Polyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed Indians |
| title_full | Polyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed Indians |
| title_fullStr | Polyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed Indians |
| title_full_unstemmed | Polyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed Indians |
| title_short | Polyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed Indians |
| title_sort | polyfunctional cd4 t cells correlating with neutralising antibody is a hallmark of covishieldtm and covaxin r induced immunity in covid 19 exposed indians |
| url | https://doi.org/10.1038/s41541-023-00731-w |
| work_keys_str_mv | AT srabantirakshit polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT sudhirbabji polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT chaitraparthiban polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT ramyamadhavan polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT vasistaadiga polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT sharonevelinej polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT niruthachetankumar polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT asmaahmed polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT sudarshanshivalingaiah polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT nandinishashikumar polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT mamathav polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT avitarosejohnson polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT naveenramesh polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT ramkrishnagoudb polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT mangaiarkarasiasokan polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT satyajitmayor polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT gagandeepkang polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT georgedsouza polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT marydias polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians AT annapurnavyakarnam polyfunctionalcd4tcellscorrelatingwithneutralisingantibodyisahallmarkofcovishieldtmandcovaxininducedimmunityincovid19exposedindians |