nab-Paclitaxel in Combination with Carboplatin for a Previously Treated Thymic Carcinoma
We present the case of a 40-year-old man with previously treated thymic carcinoma, complaining of gradually worsening back pain. Computed tomography scans of the chest showed multiple pleural disseminated nodules with a pleural effusion in the right thorax. The patient was treated with carboplatin o...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2014-01-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/357938 |
| _version_ | 1811205097255862272 |
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| author | Go Makimoto Keiichi Fujiwara Hiromi Watanabe Nobuhisa Kameyama Mizuho Matsushita Kammei Rai Ken Sato Toshiro Yonei Toshio Sato Takuo Shibayama |
| author_facet | Go Makimoto Keiichi Fujiwara Hiromi Watanabe Nobuhisa Kameyama Mizuho Matsushita Kammei Rai Ken Sato Toshiro Yonei Toshio Sato Takuo Shibayama |
| author_sort | Go Makimoto |
| collection | DOAJ |
| description | We present the case of a 40-year-old man with previously treated thymic carcinoma, complaining of gradually worsening back pain. Computed tomography scans of the chest showed multiple pleural disseminated nodules with a pleural effusion in the right thorax. The patient was treated with carboplatin on day 1 plus nab-paclitaxel on day 1 and 8 in cycles repeated every 4 weeks. Objective tumor shrinkage was observed after 4 cycles of this regimen. In addition, the elevated serum cytokeratin 19 fragment level decreased, and the patient's back pain was relieved without any analgesics. Although he experienced grade 4 neutropenia and granulocyte colony-stimulating factor (G-CSF) injection, the severity of thrombocytopenia and nonhematological toxicities such as reversible neuropathy did not exceed grade 1 during the treatment. To our knowledge, this is the first report to demonstrate the efficacy of combination chemotherapy consisting of carboplatin and nab-paclitaxel against thymic carcinoma. This case report suggests that nab-paclitaxel in combination with carboplatin can be a favorable chemotherapy regimen for advanced thymic carcinoma. |
| first_indexed | 2024-04-12T03:25:52Z |
| format | Article |
| id | doaj.art-30f53d9a89f542cf8e22197758a41a78 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-12T03:25:52Z |
| publishDate | 2014-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-30f53d9a89f542cf8e22197758a41a782022-12-22T03:49:43ZengKarger PublishersCase Reports in Oncology1662-65752014-01-0171141710.1159/000357938357938nab-Paclitaxel in Combination with Carboplatin for a Previously Treated Thymic CarcinomaGo MakimotoKeiichi FujiwaraHiromi WatanabeNobuhisa KameyamaMizuho MatsushitaKammei RaiKen SatoToshiro YoneiToshio SatoTakuo ShibayamaWe present the case of a 40-year-old man with previously treated thymic carcinoma, complaining of gradually worsening back pain. Computed tomography scans of the chest showed multiple pleural disseminated nodules with a pleural effusion in the right thorax. The patient was treated with carboplatin on day 1 plus nab-paclitaxel on day 1 and 8 in cycles repeated every 4 weeks. Objective tumor shrinkage was observed after 4 cycles of this regimen. In addition, the elevated serum cytokeratin 19 fragment level decreased, and the patient's back pain was relieved without any analgesics. Although he experienced grade 4 neutropenia and granulocyte colony-stimulating factor (G-CSF) injection, the severity of thrombocytopenia and nonhematological toxicities such as reversible neuropathy did not exceed grade 1 during the treatment. To our knowledge, this is the first report to demonstrate the efficacy of combination chemotherapy consisting of carboplatin and nab-paclitaxel against thymic carcinoma. This case report suggests that nab-paclitaxel in combination with carboplatin can be a favorable chemotherapy regimen for advanced thymic carcinoma.http://www.karger.com/Article/FullText/357938Thymic carcinomanab-PaclitaxelCarboplatinChemotherapy |
| spellingShingle | Go Makimoto Keiichi Fujiwara Hiromi Watanabe Nobuhisa Kameyama Mizuho Matsushita Kammei Rai Ken Sato Toshiro Yonei Toshio Sato Takuo Shibayama nab-Paclitaxel in Combination with Carboplatin for a Previously Treated Thymic Carcinoma Case Reports in Oncology Thymic carcinoma nab-Paclitaxel Carboplatin Chemotherapy |
| title | nab-Paclitaxel in Combination with Carboplatin for a Previously Treated Thymic Carcinoma |
| title_full | nab-Paclitaxel in Combination with Carboplatin for a Previously Treated Thymic Carcinoma |
| title_fullStr | nab-Paclitaxel in Combination with Carboplatin for a Previously Treated Thymic Carcinoma |
| title_full_unstemmed | nab-Paclitaxel in Combination with Carboplatin for a Previously Treated Thymic Carcinoma |
| title_short | nab-Paclitaxel in Combination with Carboplatin for a Previously Treated Thymic Carcinoma |
| title_sort | nab paclitaxel in combination with carboplatin for a previously treated thymic carcinoma |
| topic | Thymic carcinoma nab-Paclitaxel Carboplatin Chemotherapy |
| url | http://www.karger.com/Article/FullText/357938 |
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