High‐Sensitivity C‐Reactive Protein Is Associated With Heart Failure Hospitalization in Patients With Metabolic Dysfunction‐Associated Fatty Liver Disease and Normal Left Ventricular Ejection Fraction Undergoing Coronary Angiography
Background Systemic chronic inflammation plays a role in the pathophysiology of both heart failure with preserved ejection fraction (HFpEF) and metabolic dysfunction‐associated fatty liver disease. This study aimed to investigate whether serum hs‐CRP (high‐sensitivity C‐reactive protein) levels were...
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.123.032997 |
| _version_ | 1797296257882914816 |
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| author | Xiao‐Dong Zhou Qin‐Fen Chen Giovanni Targher Christopher D. Byrne Michael D. Shapiro Na Tian Tie Xiao Ki‐Chul Sung Gregory Y. H. Lip Ming‐Hua Zheng |
| author_facet | Xiao‐Dong Zhou Qin‐Fen Chen Giovanni Targher Christopher D. Byrne Michael D. Shapiro Na Tian Tie Xiao Ki‐Chul Sung Gregory Y. H. Lip Ming‐Hua Zheng |
| author_sort | Xiao‐Dong Zhou |
| collection | DOAJ |
| description | Background Systemic chronic inflammation plays a role in the pathophysiology of both heart failure with preserved ejection fraction (HFpEF) and metabolic dysfunction‐associated fatty liver disease. This study aimed to investigate whether serum hs‐CRP (high‐sensitivity C‐reactive protein) levels were associated with the future risk of heart failure (HF) hospitalization in patients with metabolic dysfunction‐associated fatty liver disease and a normal left ventricular ejection fraction. Methods and Results The study enrolled consecutive individuals with metabolic dysfunction‐associated fatty liver disease and normal left ventricular ejection fraction who underwent coronary angiography for suspected coronary heart disease. The study population was subdivided into non‐HF, pre‐HFpEF, and HFpEF groups at baseline. The study outcome was time to the first hospitalization for HF. In 10 019 middle‐aged individuals (mean age, 63.3±10.6 years; 38.5% women), the prevalence rates of HFpEF and pre‐HFpEF were 34.2% and 34.5%, with a median serum hs‐CRP level of 4.5 mg/L (interquartile range, 1.9–10 mg/L) and 5.0 mg/L (interquartile range, 2.1–10.1 mg/L), respectively. Serum hs‐CRP levels were significantly higher in the pre‐HFpEF and HFpEF groups than in the non‐HF group. HF hospitalizations occurred in 1942 (19.4%) patients over a median of 3.2 years, with rates of 3.7% in non‐HF, 20.8% in pre‐HFpEF, and 32.1% in HFpEF, respectively. Cox regression analyses showed that patients in the highest hs‐CRP quartile had a ≈4.5‐fold increased risk of being hospitalized for HF compared with those in the lowest hs‐CRP quartile (adjusted‐hazard ratio, 4.42 [95% CI, 3.72–5.25]). Conclusions There was a high prevalence of baseline pre‐HFpEF and HFpEF in patients with metabolic dysfunction‐associated fatty liver disease and suspected coronary heart disease. There was an increased risk of HF hospitalization in those with elevated hs‐CRP levels. |
| first_indexed | 2024-03-07T22:01:58Z |
| format | Article |
| id | doaj.art-30f5992e2cd34bafa4b6c321e0047d4c |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-03-07T22:01:58Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-30f5992e2cd34bafa4b6c321e0047d4c2024-02-24T04:06:35ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802024-02-0113310.1161/JAHA.123.032997High‐Sensitivity C‐Reactive Protein Is Associated With Heart Failure Hospitalization in Patients With Metabolic Dysfunction‐Associated Fatty Liver Disease and Normal Left Ventricular Ejection Fraction Undergoing Coronary AngiographyXiao‐Dong Zhou0Qin‐Fen Chen1Giovanni Targher2Christopher D. Byrne3Michael D. Shapiro4Na Tian5Tie Xiao6Ki‐Chul Sung7Gregory Y. H. Lip8Ming‐Hua Zheng9Department of Cardiovascular Medicine, The Heart Center The First Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaMedical Care Center The First Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaDepartment of Medicine University of Verona ItalySouthampton National Institute for Health and Care Research Biomedical Research Centre University Hospital Southampton, and University of Southampton, Southampton General Hospital Southampton United KingdomCenter for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine Wake Forest University School of Medicine Winston‐Salem NCMAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaMAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaDepartment of Internal Medicine, Division of Cardiology Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine Seoul KoreaLiverpool Centre for Cardiovascular Science at University of Liverpool Liverpool John Moores University and Liverpool Heart & Chest Hospital Liverpool United KingdomMAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaBackground Systemic chronic inflammation plays a role in the pathophysiology of both heart failure with preserved ejection fraction (HFpEF) and metabolic dysfunction‐associated fatty liver disease. This study aimed to investigate whether serum hs‐CRP (high‐sensitivity C‐reactive protein) levels were associated with the future risk of heart failure (HF) hospitalization in patients with metabolic dysfunction‐associated fatty liver disease and a normal left ventricular ejection fraction. Methods and Results The study enrolled consecutive individuals with metabolic dysfunction‐associated fatty liver disease and normal left ventricular ejection fraction who underwent coronary angiography for suspected coronary heart disease. The study population was subdivided into non‐HF, pre‐HFpEF, and HFpEF groups at baseline. The study outcome was time to the first hospitalization for HF. In 10 019 middle‐aged individuals (mean age, 63.3±10.6 years; 38.5% women), the prevalence rates of HFpEF and pre‐HFpEF were 34.2% and 34.5%, with a median serum hs‐CRP level of 4.5 mg/L (interquartile range, 1.9–10 mg/L) and 5.0 mg/L (interquartile range, 2.1–10.1 mg/L), respectively. Serum hs‐CRP levels were significantly higher in the pre‐HFpEF and HFpEF groups than in the non‐HF group. HF hospitalizations occurred in 1942 (19.4%) patients over a median of 3.2 years, with rates of 3.7% in non‐HF, 20.8% in pre‐HFpEF, and 32.1% in HFpEF, respectively. Cox regression analyses showed that patients in the highest hs‐CRP quartile had a ≈4.5‐fold increased risk of being hospitalized for HF compared with those in the lowest hs‐CRP quartile (adjusted‐hazard ratio, 4.42 [95% CI, 3.72–5.25]). Conclusions There was a high prevalence of baseline pre‐HFpEF and HFpEF in patients with metabolic dysfunction‐associated fatty liver disease and suspected coronary heart disease. There was an increased risk of HF hospitalization in those with elevated hs‐CRP levels.https://www.ahajournals.org/doi/10.1161/JAHA.123.032997heart failure hospitalizationheart failure with preserved ejection fractionhigh‐sensitivity C‐reactive proteinmetabolic dysfunction‐associated fatty liver diseasemetabolic dysfunction‐associated steatotic liver disease |
| spellingShingle | Xiao‐Dong Zhou Qin‐Fen Chen Giovanni Targher Christopher D. Byrne Michael D. Shapiro Na Tian Tie Xiao Ki‐Chul Sung Gregory Y. H. Lip Ming‐Hua Zheng High‐Sensitivity C‐Reactive Protein Is Associated With Heart Failure Hospitalization in Patients With Metabolic Dysfunction‐Associated Fatty Liver Disease and Normal Left Ventricular Ejection Fraction Undergoing Coronary Angiography Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease heart failure hospitalization heart failure with preserved ejection fraction high‐sensitivity C‐reactive protein metabolic dysfunction‐associated fatty liver disease metabolic dysfunction‐associated steatotic liver disease |
| title | High‐Sensitivity C‐Reactive Protein Is Associated With Heart Failure Hospitalization in Patients With Metabolic Dysfunction‐Associated Fatty Liver Disease and Normal Left Ventricular Ejection Fraction Undergoing Coronary Angiography |
| title_full | High‐Sensitivity C‐Reactive Protein Is Associated With Heart Failure Hospitalization in Patients With Metabolic Dysfunction‐Associated Fatty Liver Disease and Normal Left Ventricular Ejection Fraction Undergoing Coronary Angiography |
| title_fullStr | High‐Sensitivity C‐Reactive Protein Is Associated With Heart Failure Hospitalization in Patients With Metabolic Dysfunction‐Associated Fatty Liver Disease and Normal Left Ventricular Ejection Fraction Undergoing Coronary Angiography |
| title_full_unstemmed | High‐Sensitivity C‐Reactive Protein Is Associated With Heart Failure Hospitalization in Patients With Metabolic Dysfunction‐Associated Fatty Liver Disease and Normal Left Ventricular Ejection Fraction Undergoing Coronary Angiography |
| title_short | High‐Sensitivity C‐Reactive Protein Is Associated With Heart Failure Hospitalization in Patients With Metabolic Dysfunction‐Associated Fatty Liver Disease and Normal Left Ventricular Ejection Fraction Undergoing Coronary Angiography |
| title_sort | high sensitivity c reactive protein is associated with heart failure hospitalization in patients with metabolic dysfunction associated fatty liver disease and normal left ventricular ejection fraction undergoing coronary angiography |
| topic | heart failure hospitalization heart failure with preserved ejection fraction high‐sensitivity C‐reactive protein metabolic dysfunction‐associated fatty liver disease metabolic dysfunction‐associated steatotic liver disease |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.123.032997 |
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