The hepatocellular carcinoma's risk factors among in-hospital patients at the university-teaching hospital Yalgado Ouédraogo in Ouagadougou, Burkina Faso: A case-control study
Introduction: The hepatocellular carcinoma (HCC) remains one of the most frequent cancers in Africa. Our objective was to identify the risk factors of the primary liver cancer occurrence among hospitalized patients in the gastro-enterology unit of the university teaching hospital Yalgado Ouédraogo....
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Clinical Epidemiology and Global Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213398421002554 |
| _version_ | 1818312561496424448 |
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| author | Eric Nagaonlé Somé Nanelin Alice Guingané Hermann Ouédraogo Grissoum Tarnagda Séni Kouanda Roger Sombié |
| author_facet | Eric Nagaonlé Somé Nanelin Alice Guingané Hermann Ouédraogo Grissoum Tarnagda Séni Kouanda Roger Sombié |
| author_sort | Eric Nagaonlé Somé |
| collection | DOAJ |
| description | Introduction: The hepatocellular carcinoma (HCC) remains one of the most frequent cancers in Africa. Our objective was to identify the risk factors of the primary liver cancer occurrence among hospitalized patients in the gastro-enterology unit of the university teaching hospital Yalgado Ouédraogo. Methods: We implemented a case-control study and collected data from January 1, 2012 to the December 31, 2015. Controls were recruited among blood donors. Cases were selected among patients visiting the gastro-enterology unit of the Yalgado Ouédraogo Hospital. Cases were matched to the controls using age and sex variables. In our multivariate logistic regression model, the outcome variable was the occurrence of the liver cancer. The main independent variable was the chronic carriage of HbsAg. Results: We included 92 cases and 92 controls. The sex ratio was 3. Chronic carriage of HBsAg was diagnosed among 14.13% and 76% of controls and cases, respectively. The anti-HCV Ab test was positive in 15.22% of the cases and 4.35% of the controls. Being 50 years or older, HbsAg chronic carrier, farmer or working in the informal sector or living in a provincial capital were the main statistically significant risk factors to develop primary liver cancer. Conclusion: In Burkina-Faso, liver cancer patients reached out to hospital very late. Our best tools to reduce the incidence and the mortality due to the primary liver cancer include immunizing largely against the HBV infection taking into account the birth dose; and managing adequately the cases of HBV and HCV infections. |
| first_indexed | 2024-12-13T08:19:49Z |
| format | Article |
| id | doaj.art-30f5d3f63d9d4227abbc559827b692ee |
| institution | Directory Open Access Journal |
| issn | 2213-3984 |
| language | English |
| last_indexed | 2024-12-13T08:19:49Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Epidemiology and Global Health |
| spelling | doaj.art-30f5d3f63d9d4227abbc559827b692ee2022-12-21T23:54:01ZengElsevierClinical Epidemiology and Global Health2213-39842022-01-0113100947The hepatocellular carcinoma's risk factors among in-hospital patients at the university-teaching hospital Yalgado Ouédraogo in Ouagadougou, Burkina Faso: A case-control studyEric Nagaonlé Somé0Nanelin Alice Guingané1Hermann Ouédraogo2Grissoum Tarnagda3Séni Kouanda4Roger Sombié5Institut de recherche en sciences de la santé (IRSS) CNRST Ouagadougou, Burkina Faso; Corresponding author. 10 BP 250 Ouagadougou 10, Burkina Faso.Département de gastro-entérologie, UFR/SDS, Université Joseph Ki-Zerbo, Ouagadougou, Burkina FasoDépartement d'orthopédie-traumatologie, UFR/SDS, Université Joseph Ki-Zerbo, Ouagadougou, Burkina FasoInstitut de recherche en sciences de la santé (IRSS) CNRST Ouagadougou, Burkina FasoInstitut de recherche en sciences de la santé (IRSS) CNRST Ouagadougou, Burkina FasoDépartement de gastro-entérologie, UFR/SDS, Université Joseph Ki-Zerbo, Ouagadougou, Burkina FasoIntroduction: The hepatocellular carcinoma (HCC) remains one of the most frequent cancers in Africa. Our objective was to identify the risk factors of the primary liver cancer occurrence among hospitalized patients in the gastro-enterology unit of the university teaching hospital Yalgado Ouédraogo. Methods: We implemented a case-control study and collected data from January 1, 2012 to the December 31, 2015. Controls were recruited among blood donors. Cases were selected among patients visiting the gastro-enterology unit of the Yalgado Ouédraogo Hospital. Cases were matched to the controls using age and sex variables. In our multivariate logistic regression model, the outcome variable was the occurrence of the liver cancer. The main independent variable was the chronic carriage of HbsAg. Results: We included 92 cases and 92 controls. The sex ratio was 3. Chronic carriage of HBsAg was diagnosed among 14.13% and 76% of controls and cases, respectively. The anti-HCV Ab test was positive in 15.22% of the cases and 4.35% of the controls. Being 50 years or older, HbsAg chronic carrier, farmer or working in the informal sector or living in a provincial capital were the main statistically significant risk factors to develop primary liver cancer. Conclusion: In Burkina-Faso, liver cancer patients reached out to hospital very late. Our best tools to reduce the incidence and the mortality due to the primary liver cancer include immunizing largely against the HBV infection taking into account the birth dose; and managing adequately the cases of HBV and HCV infections.http://www.sciencedirect.com/science/article/pii/S2213398421002554Hepato-cellular carcinomaPrimary liver cancerHepatitis B infectionRisk factorSub Saharan Africa |
| spellingShingle | Eric Nagaonlé Somé Nanelin Alice Guingané Hermann Ouédraogo Grissoum Tarnagda Séni Kouanda Roger Sombié The hepatocellular carcinoma's risk factors among in-hospital patients at the university-teaching hospital Yalgado Ouédraogo in Ouagadougou, Burkina Faso: A case-control study Clinical Epidemiology and Global Health Hepato-cellular carcinoma Primary liver cancer Hepatitis B infection Risk factor Sub Saharan Africa |
| title | The hepatocellular carcinoma's risk factors among in-hospital patients at the university-teaching hospital Yalgado Ouédraogo in Ouagadougou, Burkina Faso: A case-control study |
| title_full | The hepatocellular carcinoma's risk factors among in-hospital patients at the university-teaching hospital Yalgado Ouédraogo in Ouagadougou, Burkina Faso: A case-control study |
| title_fullStr | The hepatocellular carcinoma's risk factors among in-hospital patients at the university-teaching hospital Yalgado Ouédraogo in Ouagadougou, Burkina Faso: A case-control study |
| title_full_unstemmed | The hepatocellular carcinoma's risk factors among in-hospital patients at the university-teaching hospital Yalgado Ouédraogo in Ouagadougou, Burkina Faso: A case-control study |
| title_short | The hepatocellular carcinoma's risk factors among in-hospital patients at the university-teaching hospital Yalgado Ouédraogo in Ouagadougou, Burkina Faso: A case-control study |
| title_sort | hepatocellular carcinoma s risk factors among in hospital patients at the university teaching hospital yalgado ouedraogo in ouagadougou burkina faso a case control study |
| topic | Hepato-cellular carcinoma Primary liver cancer Hepatitis B infection Risk factor Sub Saharan Africa |
| url | http://www.sciencedirect.com/science/article/pii/S2213398421002554 |
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