The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes
Regulation of the equilibrium between proteases and their inhibitors is fundamental to health maintenance. Consequently, developing a means of targeting protease activity to promote tissue regeneration and inhibit inflammation may offer a new strategy in therapy development for diabetes and other di...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/12/1/67 |
| _version_ | 1827666372063133696 |
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| author | Yury Kryvalap Jan Czyzyk |
| author_facet | Yury Kryvalap Jan Czyzyk |
| author_sort | Yury Kryvalap |
| collection | DOAJ |
| description | Regulation of the equilibrium between proteases and their inhibitors is fundamental to health maintenance. Consequently, developing a means of targeting protease activity to promote tissue regeneration and inhibit inflammation may offer a new strategy in therapy development for diabetes and other diseases. Specifically, recent efforts have focused on serine protease inhibitors, known as serpins, as potential therapeutic targets. The serpin protein family comprises a broad range of protease inhibitors, which are categorized into 16 clades that are all extracellular, with the exception of Clade B, which controls mostly intracellular proteases, including both serine- and papain-like cysteine proteases. This review discusses the most salient, and sometimes opposing, views that either inhibition or augmentation of protease activity can bring about positive outcomes in pancreatic islet biology and inflammation. These potential discrepancies can be reconciled at the molecular level as specific proteases and serpins regulate distinct signaling pathways, thereby playing equally distinct roles in health and disease development. |
| first_indexed | 2024-03-10T01:49:50Z |
| format | Article |
| id | doaj.art-30f730b9fb964baa92368b27661d6765 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T01:49:50Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-30f730b9fb964baa92368b27661d67652023-11-23T13:06:33ZengMDPI AGBiomolecules2218-273X2022-01-011216710.3390/biom12010067The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and DiabetesYury Kryvalap0Jan Czyzyk1Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Washington Ave. SE, Minneapolis, MN 55455, USADepartment of Laboratory Medicine and Pathology, University of Minnesota, 420 Washington Ave. SE, Minneapolis, MN 55455, USARegulation of the equilibrium between proteases and their inhibitors is fundamental to health maintenance. Consequently, developing a means of targeting protease activity to promote tissue regeneration and inhibit inflammation may offer a new strategy in therapy development for diabetes and other diseases. Specifically, recent efforts have focused on serine protease inhibitors, known as serpins, as potential therapeutic targets. The serpin protein family comprises a broad range of protease inhibitors, which are categorized into 16 clades that are all extracellular, with the exception of Clade B, which controls mostly intracellular proteases, including both serine- and papain-like cysteine proteases. This review discusses the most salient, and sometimes opposing, views that either inhibition or augmentation of protease activity can bring about positive outcomes in pancreatic islet biology and inflammation. These potential discrepancies can be reconciled at the molecular level as specific proteases and serpins regulate distinct signaling pathways, thereby playing equally distinct roles in health and disease development.https://www.mdpi.com/2218-273X/12/1/67diabetespancreatic isletproteaseserpin |
| spellingShingle | Yury Kryvalap Jan Czyzyk The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes Biomolecules diabetes pancreatic islet protease serpin |
| title | The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes |
| title_full | The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes |
| title_fullStr | The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes |
| title_full_unstemmed | The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes |
| title_short | The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes |
| title_sort | role of proteases and serpin protease inhibitors in β cell biology and diabetes |
| topic | diabetes pancreatic islet protease serpin |
| url | https://www.mdpi.com/2218-273X/12/1/67 |
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