New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR
<p>Abstract</p> <p>Corepressors are large proteins that facilitate transcriptional repression through recruitment of histone-modifying enzymes. Two major corepressors, SMRT (silencing mediator for retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor corepressor), hav...
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| Format: | Article |
| Language: | English |
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BMC
2009-04-01
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| Series: | Cell Division |
| Online Access: | http://www.celldiv.com/content/4/1/7 |
| _version_ | 1811298064138240000 |
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| author | Stanya Kristopher J Kao Hung-Ying |
| author_facet | Stanya Kristopher J Kao Hung-Ying |
| author_sort | Stanya Kristopher J |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Corepressors are large proteins that facilitate transcriptional repression through recruitment of histone-modifying enzymes. Two major corepressors, SMRT (silencing mediator for retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor corepressor), have been shown to mediate repression associated with nuclear receptors and a myriad of other transcription factors. This review will focus on recent studies on these proteins, including newly discovered physiological roles of the corepressors, their modes of regulation, their roles in antiestrogen-resistant breast cancer and their functions during the cell cycle.</p> |
| first_indexed | 2024-04-13T06:14:14Z |
| format | Article |
| id | doaj.art-30f9cf0141384c87a10a27a4e4596158 |
| institution | Directory Open Access Journal |
| issn | 1747-1028 |
| language | English |
| last_indexed | 2024-04-13T06:14:14Z |
| publishDate | 2009-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Division |
| spelling | doaj.art-30f9cf0141384c87a10a27a4e45961582022-12-22T02:58:55ZengBMCCell Division1747-10282009-04-0141710.1186/1747-1028-4-7New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoRStanya Kristopher JKao Hung-Ying<p>Abstract</p> <p>Corepressors are large proteins that facilitate transcriptional repression through recruitment of histone-modifying enzymes. Two major corepressors, SMRT (silencing mediator for retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor corepressor), have been shown to mediate repression associated with nuclear receptors and a myriad of other transcription factors. This review will focus on recent studies on these proteins, including newly discovered physiological roles of the corepressors, their modes of regulation, their roles in antiestrogen-resistant breast cancer and their functions during the cell cycle.</p>http://www.celldiv.com/content/4/1/7 |
| spellingShingle | Stanya Kristopher J Kao Hung-Ying New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR Cell Division |
| title | New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR |
| title_full | New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR |
| title_fullStr | New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR |
| title_full_unstemmed | New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR |
| title_short | New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR |
| title_sort | new insights into the functions and regulation of the transcriptional corepressors smrt and n cor |
| url | http://www.celldiv.com/content/4/1/7 |
| work_keys_str_mv | AT stanyakristopherj newinsightsintothefunctionsandregulationofthetranscriptionalcorepressorssmrtandncor AT kaohungying newinsightsintothefunctionsandregulationofthetranscriptionalcorepressorssmrtandncor |