Lomerizine attenuates LPS-induced acute lung injury by inhibiting the macrophage activation through reducing Ca2+ influx

Lomerizine attenuates LPS-induced acute lung injury by inhibiting the macrophage activation through reducing Ca2+ influx

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening lung diseases with high mortality rates, predominantly attributable to acute and severe pulmonary inflammation. Lomerizine (LMZ) is a calcium channel blocker previously used in preventing and treating migrain...

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Bibliographic Details
Main Authors: Yunduan Song, Yusen Gou, Jiameng Gao, Dongxin Chen, Haibo Zhang, Wenjuan Zhao, Feng Qian, Ajing Xu, Yao Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Pharmacology
Subjects:
lomerizine
acute lung injury
calcium
macrophage
cytokine
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1236469/full

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