KR-12-a5 Reverses Adverse Effects of Lipopolysaccharides on HBMSC Osteogenic Differentiation by Influencing BMP/Smad and P38 MAPK Signaling Pathways

KR-12-a5 Reverses Adverse Effects of Lipopolysaccharides on HBMSC Osteogenic Differentiation by Influencing BMP/Smad and P38 MAPK Signaling Pathways

KR-12-a5 is an analogue of the antimicrobial peptide KR-12. Both of these two agents can play key effects in the treatment of infections such as osteomyelitis. Our previous work demonstrated that the osteogenic differentiation of human bone marrow mesenchymal stem cells (HBMSCs) can be enhanced by K...

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Bibliographic Details
Main Authors: Hui Li, Shutao Zhang, Bin’en Nie, Teng Long, Xinhua Qu, Bing Yue
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
KR-12-a5
LPS (lipopolysaccharide)
osteogenic differentiation
p38 mitogen-activated protein kinase
BMP/Smad signal
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00639/full

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