Pregnancy-Associated Breast Cancer: A Diagnostic and Therapeutic Challenge
Pregnancy-associated breast cancer (PABC) is commonly defined as a breast cancer occurring during pregnancy, throughout 1 year postpartum, or during lactation. Despite being a rare circumstance, PABC is one of the most common types of malignancies occurring during pregnancy and lactation, with growi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/4/604 |
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| author | Francesca Galati Valentina Magri Paula Andrea Arias-Cadena Giuliana Moffa Veronica Rizzo Marcella Pasculli Andrea Botticelli Federica Pediconi |
| author_facet | Francesca Galati Valentina Magri Paula Andrea Arias-Cadena Giuliana Moffa Veronica Rizzo Marcella Pasculli Andrea Botticelli Federica Pediconi |
| author_sort | Francesca Galati |
| collection | DOAJ |
| description | Pregnancy-associated breast cancer (PABC) is commonly defined as a breast cancer occurring during pregnancy, throughout 1 year postpartum, or during lactation. Despite being a rare circumstance, PABC is one of the most common types of malignancies occurring during pregnancy and lactation, with growing incidence in developed countries, due both to decreasing age at onset of breast cancer and to increasing maternal age. Diagnosis and management of malignancy in the prenatal and postnatal settings are challenging for practitioners, as the structural and functional changes that the breast undergoes may be misleading for both the radiologist and the clinician. Furthermore, safety concerns for the mother and child, as well as psychological aspects in this unique and delicate condition, need to be constantly considered. In this comprehensive review, clinical, diagnostic, and therapeutic aspects of PABC (including surgery, chemotherapy and other systemic treatments, and radiotherapy) are presented and fully discussed, based on medical literature, current international clinical guidelines, and systematic practice. |
| first_indexed | 2024-03-11T08:56:41Z |
| format | Article |
| id | doaj.art-30fa4c04f55743de8f611dc0faa6093b |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T08:56:41Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-30fa4c04f55743de8f611dc0faa6093b2023-11-16T20:00:17ZengMDPI AGDiagnostics2075-44182023-02-0113460410.3390/diagnostics13040604Pregnancy-Associated Breast Cancer: A Diagnostic and Therapeutic ChallengeFrancesca Galati0Valentina Magri1Paula Andrea Arias-Cadena2Giuliana Moffa3Veronica Rizzo4Marcella Pasculli5Andrea Botticelli6Federica Pediconi7Department of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, 00161 Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, 00161 Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, 00161 Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, 00161 Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, 00161 Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, 00161 Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, 00161 Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, 00161 Rome, ItalyPregnancy-associated breast cancer (PABC) is commonly defined as a breast cancer occurring during pregnancy, throughout 1 year postpartum, or during lactation. Despite being a rare circumstance, PABC is one of the most common types of malignancies occurring during pregnancy and lactation, with growing incidence in developed countries, due both to decreasing age at onset of breast cancer and to increasing maternal age. Diagnosis and management of malignancy in the prenatal and postnatal settings are challenging for practitioners, as the structural and functional changes that the breast undergoes may be misleading for both the radiologist and the clinician. Furthermore, safety concerns for the mother and child, as well as psychological aspects in this unique and delicate condition, need to be constantly considered. In this comprehensive review, clinical, diagnostic, and therapeutic aspects of PABC (including surgery, chemotherapy and other systemic treatments, and radiotherapy) are presented and fully discussed, based on medical literature, current international clinical guidelines, and systematic practice.https://www.mdpi.com/2075-4418/13/4/604PABCpregnancylactationbreast imagingbreast cancer treatment |
| spellingShingle | Francesca Galati Valentina Magri Paula Andrea Arias-Cadena Giuliana Moffa Veronica Rizzo Marcella Pasculli Andrea Botticelli Federica Pediconi Pregnancy-Associated Breast Cancer: A Diagnostic and Therapeutic Challenge Diagnostics PABC pregnancy lactation breast imaging breast cancer treatment |
| title | Pregnancy-Associated Breast Cancer: A Diagnostic and Therapeutic Challenge |
| title_full | Pregnancy-Associated Breast Cancer: A Diagnostic and Therapeutic Challenge |
| title_fullStr | Pregnancy-Associated Breast Cancer: A Diagnostic and Therapeutic Challenge |
| title_full_unstemmed | Pregnancy-Associated Breast Cancer: A Diagnostic and Therapeutic Challenge |
| title_short | Pregnancy-Associated Breast Cancer: A Diagnostic and Therapeutic Challenge |
| title_sort | pregnancy associated breast cancer a diagnostic and therapeutic challenge |
| topic | PABC pregnancy lactation breast imaging breast cancer treatment |
| url | https://www.mdpi.com/2075-4418/13/4/604 |
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