The role of triiodothyronine (T3) and T3/free thyroxine (fT4) in glucose metabolism during pregnancy: the Ma’anshan birth cohort study
Objectives: Compared with other thyroid markers, fewer studies have explored the associations between triiodothyronine (T3), T3/free thyroxine (fT4) and glucose abnormality during pregnancy. Thus, we aimed to: (i) examine the associations of T3 and T3/fT4 with glucose metabolism indicators and (ii)...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2021-06-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/10/7/EC-21-0088.xml |
| _version_ | 1828937809552998400 |
|---|---|
| author | Beibei Zhu Yan Han Fen Deng Kun Huang Shuangqin Yan Jiahu Hao Peng Zhu Fangbiao Tao |
| author_facet | Beibei Zhu Yan Han Fen Deng Kun Huang Shuangqin Yan Jiahu Hao Peng Zhu Fangbiao Tao |
| author_sort | Beibei Zhu |
| collection | DOAJ |
| description | Objectives: Compared with other thyroid markers, fewer studies have explored the associations between triiodothyronine (T3), T3/free thyroxine (fT4) and glucose abnormality during pregnancy. Thus, we aimed to: (i) examine the associations of T3 and T3/fT4 with glucose metabolism indicators and (ii) evaluate, in the first trimester, the performance of the two markers as predictors of gestational diabetes mellitus (GDM) risk.
Methods: Longitudinal data from 2723 individuals, consisting of three repeated measurements of T3 and fT4, from the Man’anshan birth cohort study (MABC), China, were analyzed using a time-specific generalized estimating equat ion (GEE). The receiver operating characteristic curve (ROC) – area under the curve (AUC) and Hosmer– Lemeshow goodness of fit test was used to assess the discriminat ion and calibration of prediction models.
Results: T3 and T3/fT4 presented stable associations with the level of fasting glucose, glucose at 1h/2 h during pregnancy. T3 and T3/fT4 in both the fi rst and second trimesters were positively associated with the risk of GDM, with the larger magnitude of association observed in the second trimester (odds ratio (OR) = 2.50, 95% CI = 1.95, 3.21 for T3; OR = 1.09, 95% CI = 1.07, 1.12 for T3/fT4). T3 ((AUC) = 0.726, 95% CI = 0.698, 0.754) and T3/fT4 (AUC = 0.724, 95% CI = 0.696, 0.753) in the first trimester could improve the performance of the prediction model; however, the overall performance is not good.
Conclusion: Significant and stable associations of T3, T3/fT4 and glucose me tabolism indicators were documented. Both T3 and T3/fT4 improve the performance of the GDM predictive model. |
| first_indexed | 2024-12-14T02:30:51Z |
| format | Article |
| id | doaj.art-30fa8f14b29f430c9cb194d0d9b4f174 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-14T02:30:51Z |
| publishDate | 2021-06-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-30fa8f14b29f430c9cb194d0d9b4f1742022-12-21T23:20:15ZengBioscientificaEndocrine Connections2049-36142049-36142021-06-01107685693https://doi.org/10.1530/EC-21-0088The role of triiodothyronine (T3) and T3/free thyroxine (fT4) in glucose metabolism during pregnancy: the Ma’anshan birth cohort studyBeibei Zhu0Yan Han1Fen Deng2Kun Huang3Shuangqin Yan4Jiahu Hao5Peng Zhu6Fangbiao Tao7School of Public Health, Anhui Medical University, Hefei, Anhui, China; Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People’s Republic of China, Hefei, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China School of Public Health, Anhui Medical University, Hefei, Anhui, China; Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People’s Republic of China, Hefei, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China School of Public Health, Anhui Medical University, Hefei, Anhui, China; Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People’s Republic of China, Hefei, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China School of Public Health, Anhui Medical University, Hefei, Anhui, China; Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People’s Republic of China, Hefei, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China Ma’anshan Maternal and Child Health Care Center, Ma’anshan, Anhui, ChinaSchool of Public Health, Anhui Medical University, Hefei, Anhui, China; Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People’s Republic of China, Hefei, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China School of Public Health, Anhui Medical University, Hefei, Anhui, China; Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People’s Republic of China, Hefei, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China School of Public Health, Anhui Medical University, Hefei, Anhui, China; Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People’s Republic of China, Hefei, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China Objectives: Compared with other thyroid markers, fewer studies have explored the associations between triiodothyronine (T3), T3/free thyroxine (fT4) and glucose abnormality during pregnancy. Thus, we aimed to: (i) examine the associations of T3 and T3/fT4 with glucose metabolism indicators and (ii) evaluate, in the first trimester, the performance of the two markers as predictors of gestational diabetes mellitus (GDM) risk. Methods: Longitudinal data from 2723 individuals, consisting of three repeated measurements of T3 and fT4, from the Man’anshan birth cohort study (MABC), China, were analyzed using a time-specific generalized estimating equat ion (GEE). The receiver operating characteristic curve (ROC) – area under the curve (AUC) and Hosmer– Lemeshow goodness of fit test was used to assess the discriminat ion and calibration of prediction models. Results: T3 and T3/fT4 presented stable associations with the level of fasting glucose, glucose at 1h/2 h during pregnancy. T3 and T3/fT4 in both the fi rst and second trimesters were positively associated with the risk of GDM, with the larger magnitude of association observed in the second trimester (odds ratio (OR) = 2.50, 95% CI = 1.95, 3.21 for T3; OR = 1.09, 95% CI = 1.07, 1.12 for T3/fT4). T3 ((AUC) = 0.726, 95% CI = 0.698, 0.754) and T3/fT4 (AUC = 0.724, 95% CI = 0.696, 0.753) in the first trimester could improve the performance of the prediction model; however, the overall performance is not good. Conclusion: Significant and stable associations of T3, T3/fT4 and glucose me tabolism indicators were documented. Both T3 and T3/fT4 improve the performance of the GDM predictive model.https://ec.bioscientifica.com/view/journals/ec/10/7/EC-21-0088.xmllongitudinal studiestriiodothyroninetriiodothyronine/free thyroxineglucosepregnancy |
| spellingShingle | Beibei Zhu Yan Han Fen Deng Kun Huang Shuangqin Yan Jiahu Hao Peng Zhu Fangbiao Tao The role of triiodothyronine (T3) and T3/free thyroxine (fT4) in glucose metabolism during pregnancy: the Ma’anshan birth cohort study Endocrine Connections longitudinal studies triiodothyronine triiodothyronine/free thyroxine glucose pregnancy |
| title | The role of triiodothyronine (T3) and T3/free thyroxine (fT4) in glucose metabolism during pregnancy: the Ma’anshan birth cohort study |
| title_full | The role of triiodothyronine (T3) and T3/free thyroxine (fT4) in glucose metabolism during pregnancy: the Ma’anshan birth cohort study |
| title_fullStr | The role of triiodothyronine (T3) and T3/free thyroxine (fT4) in glucose metabolism during pregnancy: the Ma’anshan birth cohort study |
| title_full_unstemmed | The role of triiodothyronine (T3) and T3/free thyroxine (fT4) in glucose metabolism during pregnancy: the Ma’anshan birth cohort study |
| title_short | The role of triiodothyronine (T3) and T3/free thyroxine (fT4) in glucose metabolism during pregnancy: the Ma’anshan birth cohort study |
| title_sort | role of triiodothyronine t3 and t3 free thyroxine ft4 in glucose metabolism during pregnancy the ma anshan birth cohort study |
| topic | longitudinal studies triiodothyronine triiodothyronine/free thyroxine glucose pregnancy |
| url | https://ec.bioscientifica.com/view/journals/ec/10/7/EC-21-0088.xml |
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