Outcomes of Dyslipidemia Screening Program in School-aged Children
Aim:Screening of dyslipidemia in childhood has been controversial. While some guidelines recommend screening for dyslipidemia in children, others emphasize that there is insufficient evidence for screening for dyslipidemia in those less than 20 years of age. In this study, we aimed to evaluate the o...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2021-06-01
|
| Series: | Journal of Pediatric Research |
| Subjects: | |
| Online Access: |
http://jpedres.org/archives/archive-detail/article-preview/outcomes-of-dyslipidemia-screening-program-in-scho/47468
|
| _version_ | 1797913808369352704 |
|---|---|
| author | Engin Köse Melis Köse Sipil Topçu Büşra Matur Buket Barış Behzat Özkan |
| author_facet | Engin Köse Melis Köse Sipil Topçu Büşra Matur Buket Barış Behzat Özkan |
| author_sort | Engin Köse |
| collection | DOAJ |
| description | Aim:Screening of dyslipidemia in childhood has been controversial. While some guidelines recommend screening for dyslipidemia in children, others emphasize that there is insufficient evidence for screening for dyslipidemia in those less than 20 years of age. In this study, we aimed to evaluate the outcomes of a lipid screening program and reveal the pros and cons of this program.Materials and Methods:All patients referred to a paediatric metabolism outpatient clinic by family physicians with the suspicion of dyslipidemia in a lipid screening program at schools were investigated. Demographic and physical examination findings, screening lipid profiles and fasting control lipid profiles of the patients were evaluated. The definitive diagnosis with fasting lipid profile and genetic analysis were recorded.Results:Two hundred seventy-four patients suspected with dyslipidemia were enrolled in the study. The mean age of study group was 9.2±3.2 (5-17) years. While 158 (57.7%) patients were admitted with high total cholesterol (TC) and low-density lipoprotein cholesterol, high triglyceride level was detected in 58 (21.2%) patients via a paediatric lipid screening program. A high TC level was revealed in 26 (9.5%) patients.
With the control fasting lipid profile, 100 (36.5%) patients had a normal lipid profile. Fifty-nine (21.5%) patients were diagnosed with familial hypercholesterolemia (FH), and hyperchylomicronemia and hypobetalipoproteinemia were revealed in 5 (1.8%) and 4 (1.5%) patients, respectively. Eleven patients diagnosed with FH did not declare hyperlipidemia in parents. In a screening of these patients’ immediate families, 11 parents and 3 siblings were diagnosed with familial hyperlipidemia.Conclusion:This is the first study performed to date that evaluated the outcomes of a lipid screening program on school age children in Turkey. We found that this screening program is effective in diagnosing not only the patients but also asymptomatic parents and siblings. Evaluation and verification of dyslipidemia should be performed under fasting conditions to avoid false positive results. |
| first_indexed | 2024-04-10T12:17:35Z |
| format | Article |
| id | doaj.art-30faac4c4e4c4a58a387bbf23808752b |
| institution | Directory Open Access Journal |
| issn | 2587-2478 2587-2478 |
| language | English |
| last_indexed | 2024-04-10T12:17:35Z |
| publishDate | 2021-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Journal of Pediatric Research |
| spelling | doaj.art-30faac4c4e4c4a58a387bbf23808752b2023-02-15T16:15:35ZengGalenos YayineviJournal of Pediatric Research2587-24782587-24782021-06-018215516010.4274/jpr.galenos.2020.0269313049054Outcomes of Dyslipidemia Screening Program in School-aged ChildrenEngin Köse0Melis Köse1Sipil Topçu2Büşra Matur3Buket Barış4Behzat Özkan5 Ankara University Faculty of Medicine, Department of Pediatric Metabolism and Nutrition, Ankara, Turkey İzmir Katip Çelebi 3University Faculty of Medicine, Department of Pediatric Metabolism and Nutrition, İzmir, Turkey University of Health Sciences Turkey, Dr. Behçet Uz Children Training and Research Hospital, Clinic of Pediatrics, İzmir, Turkey University of Health Sciences Turkey, Dr. Behçet Uz Children Training and Research Hospital, Clinic of Pediatrics, İzmir, Turkey University of Health Sciences Turkey, Dr. Behçet Uz Children Training and Research Hospital, Clinic of Pediatrics, İzmir, Turkey University of Health Sciences Turkey, Dr. Behçet Uz Children Training and Research Hospital, Clinic of Pediatric Endocrinology, İzmir, Turkey Aim:Screening of dyslipidemia in childhood has been controversial. While some guidelines recommend screening for dyslipidemia in children, others emphasize that there is insufficient evidence for screening for dyslipidemia in those less than 20 years of age. In this study, we aimed to evaluate the outcomes of a lipid screening program and reveal the pros and cons of this program.Materials and Methods:All patients referred to a paediatric metabolism outpatient clinic by family physicians with the suspicion of dyslipidemia in a lipid screening program at schools were investigated. Demographic and physical examination findings, screening lipid profiles and fasting control lipid profiles of the patients were evaluated. The definitive diagnosis with fasting lipid profile and genetic analysis were recorded.Results:Two hundred seventy-four patients suspected with dyslipidemia were enrolled in the study. The mean age of study group was 9.2±3.2 (5-17) years. While 158 (57.7%) patients were admitted with high total cholesterol (TC) and low-density lipoprotein cholesterol, high triglyceride level was detected in 58 (21.2%) patients via a paediatric lipid screening program. A high TC level was revealed in 26 (9.5%) patients. With the control fasting lipid profile, 100 (36.5%) patients had a normal lipid profile. Fifty-nine (21.5%) patients were diagnosed with familial hypercholesterolemia (FH), and hyperchylomicronemia and hypobetalipoproteinemia were revealed in 5 (1.8%) and 4 (1.5%) patients, respectively. Eleven patients diagnosed with FH did not declare hyperlipidemia in parents. In a screening of these patients’ immediate families, 11 parents and 3 siblings were diagnosed with familial hyperlipidemia.Conclusion:This is the first study performed to date that evaluated the outcomes of a lipid screening program on school age children in Turkey. We found that this screening program is effective in diagnosing not only the patients but also asymptomatic parents and siblings. Evaluation and verification of dyslipidemia should be performed under fasting conditions to avoid false positive results. http://jpedres.org/archives/archive-detail/article-preview/outcomes-of-dyslipidemia-screening-program-in-scho/47468 screening of dyslipidemiaschool-aged childrenfamilial hypercholesterolemia |
| spellingShingle | Engin Köse Melis Köse Sipil Topçu Büşra Matur Buket Barış Behzat Özkan Outcomes of Dyslipidemia Screening Program in School-aged Children Journal of Pediatric Research screening of dyslipidemia school-aged children familial hypercholesterolemia |
| title | Outcomes of Dyslipidemia Screening Program in School-aged Children |
| title_full | Outcomes of Dyslipidemia Screening Program in School-aged Children |
| title_fullStr | Outcomes of Dyslipidemia Screening Program in School-aged Children |
| title_full_unstemmed | Outcomes of Dyslipidemia Screening Program in School-aged Children |
| title_short | Outcomes of Dyslipidemia Screening Program in School-aged Children |
| title_sort | outcomes of dyslipidemia screening program in school aged children |
| topic | screening of dyslipidemia school-aged children familial hypercholesterolemia |
| url |
http://jpedres.org/archives/archive-detail/article-preview/outcomes-of-dyslipidemia-screening-program-in-scho/47468
|
| work_keys_str_mv | AT enginkose outcomesofdyslipidemiascreeningprograminschoolagedchildren AT meliskose outcomesofdyslipidemiascreeningprograminschoolagedchildren AT sipiltopcu outcomesofdyslipidemiascreeningprograminschoolagedchildren AT busramatur outcomesofdyslipidemiascreeningprograminschoolagedchildren AT buketbarıs outcomesofdyslipidemiascreeningprograminschoolagedchildren AT behzatozkan outcomesofdyslipidemiascreeningprograminschoolagedchildren |