In Vitro Efficacy of Ebselen and BAY 11-7082 Against Naegleria fowleri

In Vitro Efficacy of Ebselen and BAY 11-7082 Against Naegleria fowleri

Primary amebic meningoencephalitis (PAM) is a fatal infection caused by the free-living ameba Naegleria fowleri, popularly known as the “brain-eating ameba.” The drugs of choice in treating PAM are the antifungal amphotericin B and an antileishmanial miltefosine, but these are not FDA-approved for t...

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Bibliographic Details
Main Authors: Anjan Debnath, Andrew T. Nelson, Angélica Silva-Olivares, Mineko Shibayama, Dionicio Siegel, James H. McKerrow
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Microbiology
Subjects:
parasite
free-living ameba
Naegleria
drug
chemotherapy
ebselen
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00414/full

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