The role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery disease
<p>Abstract</p> <p>Background</p> <p>The cholesteryl ester transfer protein (CETP) has a central role in the lipid metabolism and therefore may alter the susceptibility to atherosclerosis.</p> <p>Methods</p> <p>The DNA of 471 subjects [133 subjec...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-09-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | http://www.lipidworld.com/content/10/1/156 |
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| author | Giannakopoulou Vasiliki Papamentzelopoulos Spiridon Papadopoulou Evaggelia Mavrogeni Sophie Karakosta Agathi Kolovou Vana Vasiliadis Ioannis Kolovou Genovefa Marvaki Apostolia Degiannis Dimitrios Bilianou Helen |
| author_facet | Giannakopoulou Vasiliki Papamentzelopoulos Spiridon Papadopoulou Evaggelia Mavrogeni Sophie Karakosta Agathi Kolovou Vana Vasiliadis Ioannis Kolovou Genovefa Marvaki Apostolia Degiannis Dimitrios Bilianou Helen |
| author_sort | Giannakopoulou Vasiliki |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The cholesteryl ester transfer protein (CETP) has a central role in the lipid metabolism and therefore may alter the susceptibility to atherosclerosis.</p> <p>Methods</p> <p>The DNA of 471 subjects [133 subjects with angiographically documented left main coronary artery disease (LMCAD), 241 subjects with more peripheral coronary artery disease (MPCAD) and 97 subjects self reported healthy (Controls)] was analyzed for the frequency of TaqIB and I405V polymorphisms in the gene coding CETP.</p> <p>Results</p> <p>There is no significant difference in CETP allele frequency or genotype distribution among LMCAD and MPCAD patients although there is statistical difference between LMCAD and Controls (p = 0.001). Specifically, patients with LMCAD and B1B1 genotype of TaqIB polymorphism were more frequent present compared to Controls (33.8% vs 22.9%, respectively). The frequency of B2B2 genotype was 3 times lower in the LMCAD group compared to Controls (10.5% vs 30.2%, respectively). In the LMCAD group the frequency of B1 allele compared to Controls was higher (62% vs 46%, respectively, p = 0.001). The relationship between TaqIB gene polymorphism and the LMCAD was independent of lipid profile, with the exception of apolipoprotein A.</p> <p>Conclusions</p> <p>These findings indicate that the TaqIB polymorphism may have potential importance in screening individuals at high risk for developing CAD. However, this polymorphism cannot distinguish between LMCAD and MPCAD. Further prospective investigations in larger populations are required to confirm these findings.</p> |
| first_indexed | 2024-12-18T15:10:00Z |
| format | Article |
| id | doaj.art-30fb1d8733d44ad498ae7553f95e5dcb |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-18T15:10:00Z |
| publishDate | 2011-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-30fb1d8733d44ad498ae7553f95e5dcb2022-12-21T21:03:42ZengBMCLipids in Health and Disease1476-511X2011-09-0110115610.1186/1476-511X-10-156The role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery diseaseGiannakopoulou VasilikiPapamentzelopoulos SpiridonPapadopoulou EvaggeliaMavrogeni SophieKarakosta AgathiKolovou VanaVasiliadis IoannisKolovou GenovefaMarvaki ApostoliaDegiannis DimitriosBilianou Helen<p>Abstract</p> <p>Background</p> <p>The cholesteryl ester transfer protein (CETP) has a central role in the lipid metabolism and therefore may alter the susceptibility to atherosclerosis.</p> <p>Methods</p> <p>The DNA of 471 subjects [133 subjects with angiographically documented left main coronary artery disease (LMCAD), 241 subjects with more peripheral coronary artery disease (MPCAD) and 97 subjects self reported healthy (Controls)] was analyzed for the frequency of TaqIB and I405V polymorphisms in the gene coding CETP.</p> <p>Results</p> <p>There is no significant difference in CETP allele frequency or genotype distribution among LMCAD and MPCAD patients although there is statistical difference between LMCAD and Controls (p = 0.001). Specifically, patients with LMCAD and B1B1 genotype of TaqIB polymorphism were more frequent present compared to Controls (33.8% vs 22.9%, respectively). The frequency of B2B2 genotype was 3 times lower in the LMCAD group compared to Controls (10.5% vs 30.2%, respectively). In the LMCAD group the frequency of B1 allele compared to Controls was higher (62% vs 46%, respectively, p = 0.001). The relationship between TaqIB gene polymorphism and the LMCAD was independent of lipid profile, with the exception of apolipoprotein A.</p> <p>Conclusions</p> <p>These findings indicate that the TaqIB polymorphism may have potential importance in screening individuals at high risk for developing CAD. However, this polymorphism cannot distinguish between LMCAD and MPCAD. Further prospective investigations in larger populations are required to confirm these findings.</p>http://www.lipidworld.com/content/10/1/156Left main coronary artery diseaseatherosclerosisTaqIB polymorphismI405V polymorphism. |
| spellingShingle | Giannakopoulou Vasiliki Papamentzelopoulos Spiridon Papadopoulou Evaggelia Mavrogeni Sophie Karakosta Agathi Kolovou Vana Vasiliadis Ioannis Kolovou Genovefa Marvaki Apostolia Degiannis Dimitrios Bilianou Helen The role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery disease Lipids in Health and Disease Left main coronary artery disease atherosclerosis TaqIB polymorphism I405V polymorphism. |
| title | The role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery disease |
| title_full | The role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery disease |
| title_fullStr | The role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery disease |
| title_full_unstemmed | The role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery disease |
| title_short | The role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery disease |
| title_sort | role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery disease |
| topic | Left main coronary artery disease atherosclerosis TaqIB polymorphism I405V polymorphism. |
| url | http://www.lipidworld.com/content/10/1/156 |
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