Insulin resistance surrogate markers and risk of hyperuricemia among patients with and without coronary artery disease: a cross-sectional study
BackgroundAlthough emerging evidence emphasizes the associations between both insulin resistance and hyperuricemia with coronary artery disease (CAD) risk, no definite relationship has yet been established. In this respect, time-efficient and affordable methods to estimate insulin resistance (IR) st...
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| Format: | Article |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1048675/full |
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| author | Zeinab Ghorbani Zeinab Ghorbani Seyedeh Nooshan Mirmohammadali Nargeskhatoon Shoaibinobarian Sara K. Rosenkranz Samira Arami Azita Hekmatdoost Azita Hekmatdoost Marjan Mahdavi-Roshan Marjan Mahdavi-Roshan |
| author_facet | Zeinab Ghorbani Zeinab Ghorbani Seyedeh Nooshan Mirmohammadali Nargeskhatoon Shoaibinobarian Sara K. Rosenkranz Samira Arami Azita Hekmatdoost Azita Hekmatdoost Marjan Mahdavi-Roshan Marjan Mahdavi-Roshan |
| author_sort | Zeinab Ghorbani |
| collection | DOAJ |
| description | BackgroundAlthough emerging evidence emphasizes the associations between both insulin resistance and hyperuricemia with coronary artery disease (CAD) risk, no definite relationship has yet been established. In this respect, time-efficient and affordable methods to estimate insulin resistance (IR) status, and to predict risk of hyperuricemia, are needed. Thus, the goal of this investigation was to examine the associations between IR, as assessed by novel surrogate markers [triglyceride-glucose (TyG) and TyG–body mass index (TyG-BMI)], and risk of hyperuricemia in patients with and without diagnosed CAD.MethodsThis cross-sectional study used data from the medical records of 1,170 patients who were referred to the cardiology outpatient clinic. Medical records, anthropometrics, and serum analytes were determined at the initial visit. Hyperuricemia was defined as serum uric acid ≥ 5.6 mg/dL. IR was estimated through surrogate markers (TyG and TyG-BMI). Multiple regression analysis was performed to assess the relationship between these indices and odds of hyperuricemia among patients with and without CAD.ResultsOverall, 814 angiographically-confirmed CAD cases (mean age (SD) = 52 (8)yrs) were compared with 356 patients without CAD (mean age (SD) = 48 (8)yr). There were positive associations between TyG and TyG-BMI indices and odds of hyperuricemia in CAD patients after controlling for confounders (adjusted odds ratio (aOR) = 1.60; 95%CI: 1.02–2.51; p-value = 0.036; and aOR = 1.83; 95%CI: 1.24–2.70; p-value = 0.002, third tertiles for TYG and TYG-BMI, respectively).ConclusionThe present findings suggest that higher levels of the IR surrogate markers, TyG and TyG-BMI, are associated with higher odds of hyperuricemia in patients with CAD. However, given the cross-sectional design of this study, the sensitivity and specificity of these novel markers could not be determined for confirming the diagnosis of IR and hyperuricemia, further studies are needed to determine such outcomes and to confirm the current findings. |
| first_indexed | 2024-03-12T14:06:28Z |
| format | Article |
| id | doaj.art-30fba852b9504296965af9c191f70865 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-12T14:06:28Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-30fba852b9504296965af9c191f708652023-08-21T14:06:11ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-08-011010.3389/fnut.2023.10486751048675Insulin resistance surrogate markers and risk of hyperuricemia among patients with and without coronary artery disease: a cross-sectional studyZeinab Ghorbani0Zeinab Ghorbani1Seyedeh Nooshan Mirmohammadali2Nargeskhatoon Shoaibinobarian3Sara K. Rosenkranz4Samira Arami5Azita Hekmatdoost6Azita Hekmatdoost7Marjan Mahdavi-Roshan8Marjan Mahdavi-Roshan9Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, IranDepartment of Clinical Nutrition, School of Medicine, Guilan University of Medical Sciences, Rasht, IranDepartment of Food, Nutrition, Dietetics and Health, Kansas State University, Manhattan, KS, United StatesDepartment of Nutrition, School of Medical Sciences and Technologies, Islamic Azad University, Science and Research Branch, Tehran, IranDepartment of Kinesiology and Nutrition Sciences, University of Nevada, Las Vegas, Las Vegas, NV, United StatesDepartment of Clinical Nutrition, School of Medicine, Guilan University of Medical Sciences, Rasht, IranDepartment of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Clinical Nutrition and Dietetics, National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, IranCardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, IranDepartment of Clinical Nutrition, School of Medicine, Guilan University of Medical Sciences, Rasht, IranBackgroundAlthough emerging evidence emphasizes the associations between both insulin resistance and hyperuricemia with coronary artery disease (CAD) risk, no definite relationship has yet been established. In this respect, time-efficient and affordable methods to estimate insulin resistance (IR) status, and to predict risk of hyperuricemia, are needed. Thus, the goal of this investigation was to examine the associations between IR, as assessed by novel surrogate markers [triglyceride-glucose (TyG) and TyG–body mass index (TyG-BMI)], and risk of hyperuricemia in patients with and without diagnosed CAD.MethodsThis cross-sectional study used data from the medical records of 1,170 patients who were referred to the cardiology outpatient clinic. Medical records, anthropometrics, and serum analytes were determined at the initial visit. Hyperuricemia was defined as serum uric acid ≥ 5.6 mg/dL. IR was estimated through surrogate markers (TyG and TyG-BMI). Multiple regression analysis was performed to assess the relationship between these indices and odds of hyperuricemia among patients with and without CAD.ResultsOverall, 814 angiographically-confirmed CAD cases (mean age (SD) = 52 (8)yrs) were compared with 356 patients without CAD (mean age (SD) = 48 (8)yr). There were positive associations between TyG and TyG-BMI indices and odds of hyperuricemia in CAD patients after controlling for confounders (adjusted odds ratio (aOR) = 1.60; 95%CI: 1.02–2.51; p-value = 0.036; and aOR = 1.83; 95%CI: 1.24–2.70; p-value = 0.002, third tertiles for TYG and TYG-BMI, respectively).ConclusionThe present findings suggest that higher levels of the IR surrogate markers, TyG and TyG-BMI, are associated with higher odds of hyperuricemia in patients with CAD. However, given the cross-sectional design of this study, the sensitivity and specificity of these novel markers could not be determined for confirming the diagnosis of IR and hyperuricemia, further studies are needed to determine such outcomes and to confirm the current findings.https://www.frontiersin.org/articles/10.3389/fnut.2023.1048675/fullhyperuricemiainsulin resistancecoronary artery disease (CAD)triglycerideinsulin sensitivity |
| spellingShingle | Zeinab Ghorbani Zeinab Ghorbani Seyedeh Nooshan Mirmohammadali Nargeskhatoon Shoaibinobarian Sara K. Rosenkranz Samira Arami Azita Hekmatdoost Azita Hekmatdoost Marjan Mahdavi-Roshan Marjan Mahdavi-Roshan Insulin resistance surrogate markers and risk of hyperuricemia among patients with and without coronary artery disease: a cross-sectional study Frontiers in Nutrition hyperuricemia insulin resistance coronary artery disease (CAD) triglyceride insulin sensitivity |
| title | Insulin resistance surrogate markers and risk of hyperuricemia among patients with and without coronary artery disease: a cross-sectional study |
| title_full | Insulin resistance surrogate markers and risk of hyperuricemia among patients with and without coronary artery disease: a cross-sectional study |
| title_fullStr | Insulin resistance surrogate markers and risk of hyperuricemia among patients with and without coronary artery disease: a cross-sectional study |
| title_full_unstemmed | Insulin resistance surrogate markers and risk of hyperuricemia among patients with and without coronary artery disease: a cross-sectional study |
| title_short | Insulin resistance surrogate markers and risk of hyperuricemia among patients with and without coronary artery disease: a cross-sectional study |
| title_sort | insulin resistance surrogate markers and risk of hyperuricemia among patients with and without coronary artery disease a cross sectional study |
| topic | hyperuricemia insulin resistance coronary artery disease (CAD) triglyceride insulin sensitivity |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1048675/full |
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