Biomarkers of chronic inflammation and cognitive decline: A prospective observational study
Abstract We sought to determine whether the biomarkers of chronic inflammation predict cognitive decline in a prospective observational study. We measured baseline serum soluble urokinase plasminogen activator receptor (suPAR) and high sensitivity C‐reactive protein (hs‐CRP) levels in 282 participan...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.12568 |
| _version_ | 1827307474116411392 |
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| author | Bhavna A. Guduguntla Alexi Vasbinder Elizabeth Anderson Tariq U. Azam Pennelope Blakely Noah J. Webster Richard Gonzalez Toni Atonucci Judith L. Heidebrink Bruno Giordani Laura Zahodne Benjamin M. Hampstead Kristine J. Ajrouch Salim S. Hayek |
| author_facet | Bhavna A. Guduguntla Alexi Vasbinder Elizabeth Anderson Tariq U. Azam Pennelope Blakely Noah J. Webster Richard Gonzalez Toni Atonucci Judith L. Heidebrink Bruno Giordani Laura Zahodne Benjamin M. Hampstead Kristine J. Ajrouch Salim S. Hayek |
| author_sort | Bhavna A. Guduguntla |
| collection | DOAJ |
| description | Abstract We sought to determine whether the biomarkers of chronic inflammation predict cognitive decline in a prospective observational study. We measured baseline serum soluble urokinase plasminogen activator receptor (suPAR) and high sensitivity C‐reactive protein (hs‐CRP) levels in 282 participants of the University of Michigan Memory and Aging Project. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) and the Clinical Dementia Rating (CDR) scale for up to five time points. SuPAR and hs‐CRP levels were not significantly higher in participants with mild cognitive impairment (n = 97) or dementia (n = 59), compared to those with normal cognitive function (n = 126). Overall, 14% of participants experienced significant cognitive decline over the study period. The change in MoCA or CDR scores over time did not differ significantly according to baseline suPAR or hs‐CRP levels. Chronic systemic inflammation, as measured by serum suPAR or hs‐CRP levels, is unlikely to contribute significantly to cognitive decline. |
| first_indexed | 2024-04-24T18:40:45Z |
| format | Article |
| id | doaj.art-30fc7658454b421f906dd1ca7b105d9e |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-04-24T18:40:45Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-30fc7658454b421f906dd1ca7b105d9e2024-03-27T13:14:40ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292024-01-01161n/an/a10.1002/dad2.12568Biomarkers of chronic inflammation and cognitive decline: A prospective observational studyBhavna A. Guduguntla0Alexi Vasbinder1Elizabeth Anderson2Tariq U. Azam3Pennelope Blakely4Noah J. Webster5Richard Gonzalez6Toni Atonucci7Judith L. Heidebrink8Bruno Giordani9Laura Zahodne10Benjamin M. Hampstead11Kristine J. Ajrouch12Salim S. Hayek13University of Michigan Medical School Ann Arbor Michigan USADivision of Cardiology Department of Internal Medicine University of Michigan Ann Arbor Michigan USADivision of Cardiology Department of Internal Medicine University of Michigan Ann Arbor Michigan USADivision of Cardiology Department of Internal Medicine University of Michigan Ann Arbor Michigan USADivision of Cardiology Department of Internal Medicine University of Michigan Ann Arbor Michigan USAInstitute for Social Research University of Michigan Ann Arbor Michigan USADepartment of Psychology University of Michigan Ann Arbor Michigan USADepartment of Psychology University of Michigan Ann Arbor Michigan USADepartment of Neurology University of Michigan Ann Arbor Michigan USADepartment of Psychology University of Michigan Ann Arbor Michigan USADepartment of Psychology University of Michigan Ann Arbor Michigan USADepartment of Psychiatry University of Michigan Ann Arbor Michigan USAInstitute for Social Research University of Michigan Ann Arbor Michigan USADivision of Cardiology Department of Internal Medicine University of Michigan Ann Arbor Michigan USAAbstract We sought to determine whether the biomarkers of chronic inflammation predict cognitive decline in a prospective observational study. We measured baseline serum soluble urokinase plasminogen activator receptor (suPAR) and high sensitivity C‐reactive protein (hs‐CRP) levels in 282 participants of the University of Michigan Memory and Aging Project. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) and the Clinical Dementia Rating (CDR) scale for up to five time points. SuPAR and hs‐CRP levels were not significantly higher in participants with mild cognitive impairment (n = 97) or dementia (n = 59), compared to those with normal cognitive function (n = 126). Overall, 14% of participants experienced significant cognitive decline over the study period. The change in MoCA or CDR scores over time did not differ significantly according to baseline suPAR or hs‐CRP levels. Chronic systemic inflammation, as measured by serum suPAR or hs‐CRP levels, is unlikely to contribute significantly to cognitive decline.https://doi.org/10.1002/dad2.12568Alzheimer's diseasecognitiondementiahs‐CRPsuPAR |
| spellingShingle | Bhavna A. Guduguntla Alexi Vasbinder Elizabeth Anderson Tariq U. Azam Pennelope Blakely Noah J. Webster Richard Gonzalez Toni Atonucci Judith L. Heidebrink Bruno Giordani Laura Zahodne Benjamin M. Hampstead Kristine J. Ajrouch Salim S. Hayek Biomarkers of chronic inflammation and cognitive decline: A prospective observational study Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Alzheimer's disease cognition dementia hs‐CRP suPAR |
| title | Biomarkers of chronic inflammation and cognitive decline: A prospective observational study |
| title_full | Biomarkers of chronic inflammation and cognitive decline: A prospective observational study |
| title_fullStr | Biomarkers of chronic inflammation and cognitive decline: A prospective observational study |
| title_full_unstemmed | Biomarkers of chronic inflammation and cognitive decline: A prospective observational study |
| title_short | Biomarkers of chronic inflammation and cognitive decline: A prospective observational study |
| title_sort | biomarkers of chronic inflammation and cognitive decline a prospective observational study |
| topic | Alzheimer's disease cognition dementia hs‐CRP suPAR |
| url | https://doi.org/10.1002/dad2.12568 |
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