The Type IX Secretion System: Advances in Structure, Function and Organisation
The type IX secretion system (T9SS) is specific to the <i>Bacteroidetes</i> phylum. <i>Porphyromonas gingivalis</i>, a keystone pathogen for periodontitis, utilises the T9SS to transport many proteins—including its gingipain virulence factors—across the outer membrane and att...
| Những tác giả chính: | , , |
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| Định dạng: | Bài viết |
| Ngôn ngữ: | English |
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MDPI AG
2020-08-01
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| Loạt: | Microorganisms |
| Những chủ đề: | |
| Truy cập trực tuyến: | https://www.mdpi.com/2076-2607/8/8/1173 |
| _version_ | 1827711812691296256 |
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| author | Dhana G. Gorasia Paul D. Veith Eric C. Reynolds |
| author_facet | Dhana G. Gorasia Paul D. Veith Eric C. Reynolds |
| author_sort | Dhana G. Gorasia |
| collection | DOAJ |
| description | The type IX secretion system (T9SS) is specific to the <i>Bacteroidetes</i> phylum. <i>Porphyromonas gingivalis</i>, a keystone pathogen for periodontitis, utilises the T9SS to transport many proteins—including its gingipain virulence factors—across the outer membrane and attach them to the cell surface. Additionally, the T9SS is also required for gliding motility in motile organisms, such as <i>Flavobacterium johnsoniae.</i> At least nineteen proteins have been identified as components of the T9SS, including the three transcription regulators, PorX, PorY and SigP. Although the components are known, the overall organisation and the molecular mechanism of how the T9SS operates is largely unknown. This review focusses on the recent advances made in the structure, function, and organisation of the T9SS machinery to provide further insight into this highly novel secretion system. |
| first_indexed | 2024-03-10T18:01:54Z |
| format | Article |
| id | doaj.art-31016116806d4b45abfa1b858a36599b |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T18:01:54Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-31016116806d4b45abfa1b858a36599b2023-11-20T08:48:03ZengMDPI AGMicroorganisms2076-26072020-08-0188117310.3390/microorganisms8081173The Type IX Secretion System: Advances in Structure, Function and OrganisationDhana G. Gorasia0Paul D. Veith1Eric C. Reynolds2Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Melbourne VIC 3010, AustraliaOral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Melbourne VIC 3010, AustraliaOral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Melbourne VIC 3010, AustraliaThe type IX secretion system (T9SS) is specific to the <i>Bacteroidetes</i> phylum. <i>Porphyromonas gingivalis</i>, a keystone pathogen for periodontitis, utilises the T9SS to transport many proteins—including its gingipain virulence factors—across the outer membrane and attach them to the cell surface. Additionally, the T9SS is also required for gliding motility in motile organisms, such as <i>Flavobacterium johnsoniae.</i> At least nineteen proteins have been identified as components of the T9SS, including the three transcription regulators, PorX, PorY and SigP. Although the components are known, the overall organisation and the molecular mechanism of how the T9SS operates is largely unknown. This review focusses on the recent advances made in the structure, function, and organisation of the T9SS machinery to provide further insight into this highly novel secretion system.https://www.mdpi.com/2076-2607/8/8/1173bacterial protein secretiontype IX secretion systemcell-surface attachment<i>Porphyromonas gingivalis</i>Flavobacterium johnsoniae |
| spellingShingle | Dhana G. Gorasia Paul D. Veith Eric C. Reynolds The Type IX Secretion System: Advances in Structure, Function and Organisation Microorganisms bacterial protein secretion type IX secretion system cell-surface attachment <i>Porphyromonas gingivalis</i> Flavobacterium johnsoniae |
| title | The Type IX Secretion System: Advances in Structure, Function and Organisation |
| title_full | The Type IX Secretion System: Advances in Structure, Function and Organisation |
| title_fullStr | The Type IX Secretion System: Advances in Structure, Function and Organisation |
| title_full_unstemmed | The Type IX Secretion System: Advances in Structure, Function and Organisation |
| title_short | The Type IX Secretion System: Advances in Structure, Function and Organisation |
| title_sort | type ix secretion system advances in structure function and organisation |
| topic | bacterial protein secretion type IX secretion system cell-surface attachment <i>Porphyromonas gingivalis</i> Flavobacterium johnsoniae |
| url | https://www.mdpi.com/2076-2607/8/8/1173 |
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