Development and validation of a simple and rapid ICP-OES method for quantification of elemental impurities in voriconazole drug substance
Abstract Background The aim of the present study was to develop and validate an inductively coupled plasma optical emission spectroscopic (ICP–OES) method for quantification of elemental impurities, i.e., Lead, Palladium, and Zinc, in voriconazole drug substance, and this method was employed for the...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-02-01
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| Series: | Future Journal of Pharmaceutical Sciences |
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| Online Access: | https://doi.org/10.1186/s43094-020-00159-2 |
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| author | Kishore V. Merusomayajula Siva Rao Tirukkovalluri Rama Srinivas Kommula Sathyendranath Venkata Chakkirala Jagadeesh Kumar Vundavilli Pavan Kumar S. R. Kottapalli |
| author_facet | Kishore V. Merusomayajula Siva Rao Tirukkovalluri Rama Srinivas Kommula Sathyendranath Venkata Chakkirala Jagadeesh Kumar Vundavilli Pavan Kumar S. R. Kottapalli |
| author_sort | Kishore V. Merusomayajula |
| collection | DOAJ |
| description | Abstract Background The aim of the present study was to develop and validate an inductively coupled plasma optical emission spectroscopic (ICP–OES) method for quantification of elemental impurities, i.e., Lead, Palladium, and Zinc, in voriconazole drug substance, and this method was employed for the regular sample analysis of Lead, Palladium, and Zinc in voriconazole drug substance for pharmaceutical use. The method has been validated using RF power of 1150 W, auxiliary gas of 0.5 L/min, and nebulizer flow of 0.4 L/min and plasma view at axial mode for Lead and Palladium and radial mode for Zinc. The wavelength was monitored for Lead, Palladium, and Zinc at 220.3 nm, 340.4 nm, and 213.8 nm respectively. Results The method is selective and is capable of detecting desired elemental impurities with regulatory acceptance limits in the presence of other elements. The validation experiments involve the demonstration of system suitability, specificity, LOD and LOQ, linearity, precision, and accuracy experiments. The linearity results obtained ˃ 0.9990 for all three impurities. Conclusion The proposed method is simple, sensitive quality control tool for the simultaneous quantitative determination of Lead, Palladium, and Zinc at low levels in voriconazole drug substance. Graphical abstract |
| first_indexed | 2024-12-19T07:38:02Z |
| format | Article |
| id | doaj.art-3101eee8537e42ac9e1f06218536e30a |
| institution | Directory Open Access Journal |
| issn | 2314-7253 |
| language | English |
| last_indexed | 2024-12-19T07:38:02Z |
| publishDate | 2021-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj.art-3101eee8537e42ac9e1f06218536e30a2022-12-21T20:30:31ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72532021-02-017111210.1186/s43094-020-00159-2Development and validation of a simple and rapid ICP-OES method for quantification of elemental impurities in voriconazole drug substanceKishore V. Merusomayajula0Siva Rao Tirukkovalluri1Rama Srinivas Kommula2Sathyendranath Venkata Chakkirala3Jagadeesh Kumar Vundavilli4Pavan Kumar S. R. Kottapalli5Aurobindo Pharma LimitedDepartment of Inorganic and Analytical Chemistry, AU College of Science and Technology, Andhra UniversityAurobindo Pharma LimitedAurobindo Pharma LimitedAurobindo Pharma LimitedAurobindo Pharma LimitedAbstract Background The aim of the present study was to develop and validate an inductively coupled plasma optical emission spectroscopic (ICP–OES) method for quantification of elemental impurities, i.e., Lead, Palladium, and Zinc, in voriconazole drug substance, and this method was employed for the regular sample analysis of Lead, Palladium, and Zinc in voriconazole drug substance for pharmaceutical use. The method has been validated using RF power of 1150 W, auxiliary gas of 0.5 L/min, and nebulizer flow of 0.4 L/min and plasma view at axial mode for Lead and Palladium and radial mode for Zinc. The wavelength was monitored for Lead, Palladium, and Zinc at 220.3 nm, 340.4 nm, and 213.8 nm respectively. Results The method is selective and is capable of detecting desired elemental impurities with regulatory acceptance limits in the presence of other elements. The validation experiments involve the demonstration of system suitability, specificity, LOD and LOQ, linearity, precision, and accuracy experiments. The linearity results obtained ˃ 0.9990 for all three impurities. Conclusion The proposed method is simple, sensitive quality control tool for the simultaneous quantitative determination of Lead, Palladium, and Zinc at low levels in voriconazole drug substance. Graphical abstracthttps://doi.org/10.1186/s43094-020-00159-2Inductively coupled plasma optical emission spectroscopyPharmaceutical analysisElemental impuritiesVoriconazole and method validation |
| spellingShingle | Kishore V. Merusomayajula Siva Rao Tirukkovalluri Rama Srinivas Kommula Sathyendranath Venkata Chakkirala Jagadeesh Kumar Vundavilli Pavan Kumar S. R. Kottapalli Development and validation of a simple and rapid ICP-OES method for quantification of elemental impurities in voriconazole drug substance Future Journal of Pharmaceutical Sciences Inductively coupled plasma optical emission spectroscopy Pharmaceutical analysis Elemental impurities Voriconazole and method validation |
| title | Development and validation of a simple and rapid ICP-OES method for quantification of elemental impurities in voriconazole drug substance |
| title_full | Development and validation of a simple and rapid ICP-OES method for quantification of elemental impurities in voriconazole drug substance |
| title_fullStr | Development and validation of a simple and rapid ICP-OES method for quantification of elemental impurities in voriconazole drug substance |
| title_full_unstemmed | Development and validation of a simple and rapid ICP-OES method for quantification of elemental impurities in voriconazole drug substance |
| title_short | Development and validation of a simple and rapid ICP-OES method for quantification of elemental impurities in voriconazole drug substance |
| title_sort | development and validation of a simple and rapid icp oes method for quantification of elemental impurities in voriconazole drug substance |
| topic | Inductively coupled plasma optical emission spectroscopy Pharmaceutical analysis Elemental impurities Voriconazole and method validation |
| url | https://doi.org/10.1186/s43094-020-00159-2 |
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