Automatic Design of Microfluidic Gradient Generators
Concentration gradient generators are common components of microfluidic devices when specified mixing ratios have to be acquired. However, depending on their complexity, the creation of a suitable design is an elaborate task. Although approaches exist that derive such a design, they suffer from low...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IEEE
2022-01-01
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| Series: | IEEE Access |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/9732435/ |
| _version_ | 1811341897386426368 |
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| author | Gerold Fink Tina Mitteramskogler Marcus A. Hintermuller Bernhard Jakoby Robert Wille |
| author_facet | Gerold Fink Tina Mitteramskogler Marcus A. Hintermuller Bernhard Jakoby Robert Wille |
| author_sort | Gerold Fink |
| collection | DOAJ |
| description | Concentration gradient generators are common components of microfluidic devices when specified mixing ratios have to be acquired. However, depending on their complexity, the creation of a suitable design is an elaborate task. Although approaches exist that derive such a design, they suffer from low flexibility and usability, which is why most concentration gradient generators are still mainly designed manually thus far—a time-consuming and error-prone task. To tackle this problem, we propose a method for the automatic design of tree-shaped concentration gradient generators and introduce a publicly available online tool that automatically generates a suitable design by adjusting the hydrodynamic resistances within the network. Moreover, the proposed tool is not only able to generate designs complying with user-defined requirements, such as mixing ratios, flow rates, and channel widths but also works for any number of outlets. Simulations using a Computational Fluid Dynamics (CFD) tool as well as evaluations on fabricated designs confirm the quality of the results obtained by the proposed tool. |
| first_indexed | 2024-04-13T19:01:05Z |
| format | Article |
| id | doaj.art-310201a193ca43d7b84ea14b39c5dfc3 |
| institution | Directory Open Access Journal |
| issn | 2169-3536 |
| language | English |
| last_indexed | 2024-04-13T19:01:05Z |
| publishDate | 2022-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Access |
| spelling | doaj.art-310201a193ca43d7b84ea14b39c5dfc32022-12-22T02:34:05ZengIEEEIEEE Access2169-35362022-01-0110281552816410.1109/ACCESS.2022.31583279732435Automatic Design of Microfluidic Gradient GeneratorsGerold Fink0https://orcid.org/0000-0002-9749-6043Tina Mitteramskogler1https://orcid.org/0000-0003-3694-2385Marcus A. Hintermuller2https://orcid.org/0000-0002-8064-8303Bernhard Jakoby3https://orcid.org/0000-0002-2918-7150Robert Wille4https://orcid.org/0000-0002-4993-7860Institute for Integrated Circuits, Johannes Kepler University Linz, Linz, AustriaInstitute for Microelectronics and Microsensors, Johannes Kepler University Linz, Linz, AustriaInstitute for Microelectronics and Microsensors, Johannes Kepler University Linz, Linz, AustriaInstitute for Microelectronics and Microsensors, Johannes Kepler University Linz, Linz, AustriaSoftware Competence Center Hagenberg, Hagenberg, AustriaConcentration gradient generators are common components of microfluidic devices when specified mixing ratios have to be acquired. However, depending on their complexity, the creation of a suitable design is an elaborate task. Although approaches exist that derive such a design, they suffer from low flexibility and usability, which is why most concentration gradient generators are still mainly designed manually thus far—a time-consuming and error-prone task. To tackle this problem, we propose a method for the automatic design of tree-shaped concentration gradient generators and introduce a publicly available online tool that automatically generates a suitable design by adjusting the hydrodynamic resistances within the network. Moreover, the proposed tool is not only able to generate designs complying with user-defined requirements, such as mixing ratios, flow rates, and channel widths but also works for any number of outlets. Simulations using a Computational Fluid Dynamics (CFD) tool as well as evaluations on fabricated designs confirm the quality of the results obtained by the proposed tool.https://ieeexplore.ieee.org/document/9732435/Concentration gradient generatormicrofluidic mixerdesign automation |
| spellingShingle | Gerold Fink Tina Mitteramskogler Marcus A. Hintermuller Bernhard Jakoby Robert Wille Automatic Design of Microfluidic Gradient Generators IEEE Access Concentration gradient generator microfluidic mixer design automation |
| title | Automatic Design of Microfluidic Gradient Generators |
| title_full | Automatic Design of Microfluidic Gradient Generators |
| title_fullStr | Automatic Design of Microfluidic Gradient Generators |
| title_full_unstemmed | Automatic Design of Microfluidic Gradient Generators |
| title_short | Automatic Design of Microfluidic Gradient Generators |
| title_sort | automatic design of microfluidic gradient generators |
| topic | Concentration gradient generator microfluidic mixer design automation |
| url | https://ieeexplore.ieee.org/document/9732435/ |
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