Mechanical and Histological Characteristics of Human Tubular Bones after Hyperthermal Treatment
This research focused on studying regularities in changes in strength characteristics and histological patterns of healthy tubular bone tissue depending on the temperature setting of hyperthermal treatment. Experimentation has established that heating the experimental bone sample in a temperature ra...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Symmetry |
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| Online Access: | https://www.mdpi.com/2073-8994/15/1/156 |
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| author | Denis Pakhmurin Viktoriya Pakhmurina Alexander Kashin Alexey Kulkov Igor Khlusov Evgeny Kostyuchenko Ilya Anisenya Pavel Sitnikov Ekaterina Porokhova |
| author_facet | Denis Pakhmurin Viktoriya Pakhmurina Alexander Kashin Alexey Kulkov Igor Khlusov Evgeny Kostyuchenko Ilya Anisenya Pavel Sitnikov Ekaterina Porokhova |
| author_sort | Denis Pakhmurin |
| collection | DOAJ |
| description | This research focused on studying regularities in changes in strength characteristics and histological patterns of healthy tubular bone tissue depending on the temperature setting of hyperthermal treatment. Experimentation has established that heating the experimental bone sample in a temperature range of 60 to 70 °C does not cause any decline in strength characteristics compared to the control samples not subject to heat treatment. In compression tests (along the length of the bone), after heating the bone samples ex vivo to 80 °C, the strength characteristics were found to increase as the samples sustained a higher maximum stress. In bending tests, in contrast, the strength characteristics were reliably found to decrease in bone samples at 80 °C and 90 °C for the maximum stress indicator and 90 °C for the modulus of elasticity. Data obtained through histological examination further demonstrated statistically significant differences between the two temperature ranges of 60–70 °C and 80–90 °C, where semi-quantitative assessment revealed statistically significant differences in the markers of bone tissue destruction caused by hyperthermal treatment. Moderate (at 60–70 °C) and pronounced (at 80–90 °C) dystrophic and necrotic changes were observed both in the cells and the intercellular matrix of the tibia. From a practical point of view, the temperature range of 60–70 °C can be considered operational for thermal ablation since, at these temperatures, no statistically significant decline was observed for the strength characteristics in either the cross-section or length-section. |
| first_indexed | 2024-03-09T11:07:54Z |
| format | Article |
| id | doaj.art-310261bec4274d9da28a238ecba43944 |
| institution | Directory Open Access Journal |
| issn | 2073-8994 |
| language | English |
| last_indexed | 2024-03-09T11:07:54Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Symmetry |
| spelling | doaj.art-310261bec4274d9da28a238ecba439442023-12-01T00:52:43ZengMDPI AGSymmetry2073-89942023-01-0115115610.3390/sym15010156Mechanical and Histological Characteristics of Human Tubular Bones after Hyperthermal TreatmentDenis Pakhmurin0Viktoriya Pakhmurina1Alexander Kashin2Alexey Kulkov3Igor Khlusov4Evgeny Kostyuchenko5Ilya Anisenya6Pavel Sitnikov7Ekaterina Porokhova8Laboratory of Acquisition, Analysis and Control of Biological Signals, Tomsk State University of Control Systems and Radioelectronics, 40 Lenina Str., 634050 Tomsk, RussiaLaboratory of Acquisition, Analysis and Control of Biological Signals, Tomsk State University of Control Systems and Radioelectronics, 40 Lenina Str., 634050 Tomsk, RussiaInstitute of Strength Physics and Materials Science, Siberian Branch of Russian Academy of Sciences (ISPMS SB RAS), 2/4 Akademicheskiy Str., 634055 Tomsk, RussiaInstitute of Strength Physics and Materials Science, Siberian Branch of Russian Academy of Sciences (ISPMS SB RAS), 2/4 Akademicheskiy Str., 634055 Tomsk, RussiaDepartment of Morphology and General Pathology, Siberian State Medical University, 2 Moskovsky Trakt, 634050 Tomsk, RussiaLaboratory of Acquisition, Analysis and Control of Biological Signals, Tomsk State University of Control Systems and Radioelectronics, 40 Lenina Str., 634050 Tomsk, RussiaDepartment of General Oncology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Str., 634009 Tomsk, RussiaDepartment of General Oncology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Str., 634009 Tomsk, RussiaDepartment of Morphology and General Pathology, Siberian State Medical University, 2 Moskovsky Trakt, 634050 Tomsk, RussiaThis research focused on studying regularities in changes in strength characteristics and histological patterns of healthy tubular bone tissue depending on the temperature setting of hyperthermal treatment. Experimentation has established that heating the experimental bone sample in a temperature range of 60 to 70 °C does not cause any decline in strength characteristics compared to the control samples not subject to heat treatment. In compression tests (along the length of the bone), after heating the bone samples ex vivo to 80 °C, the strength characteristics were found to increase as the samples sustained a higher maximum stress. In bending tests, in contrast, the strength characteristics were reliably found to decrease in bone samples at 80 °C and 90 °C for the maximum stress indicator and 90 °C for the modulus of elasticity. Data obtained through histological examination further demonstrated statistically significant differences between the two temperature ranges of 60–70 °C and 80–90 °C, where semi-quantitative assessment revealed statistically significant differences in the markers of bone tissue destruction caused by hyperthermal treatment. Moderate (at 60–70 °C) and pronounced (at 80–90 °C) dystrophic and necrotic changes were observed both in the cells and the intercellular matrix of the tibia. From a practical point of view, the temperature range of 60–70 °C can be considered operational for thermal ablation since, at these temperatures, no statistically significant decline was observed for the strength characteristics in either the cross-section or length-section.https://www.mdpi.com/2073-8994/15/1/156bone straintissue heatingtumor treatmenthyperthermiatubular bonesthermal ablation |
| spellingShingle | Denis Pakhmurin Viktoriya Pakhmurina Alexander Kashin Alexey Kulkov Igor Khlusov Evgeny Kostyuchenko Ilya Anisenya Pavel Sitnikov Ekaterina Porokhova Mechanical and Histological Characteristics of Human Tubular Bones after Hyperthermal Treatment Symmetry bone strain tissue heating tumor treatment hyperthermia tubular bones thermal ablation |
| title | Mechanical and Histological Characteristics of Human Tubular Bones after Hyperthermal Treatment |
| title_full | Mechanical and Histological Characteristics of Human Tubular Bones after Hyperthermal Treatment |
| title_fullStr | Mechanical and Histological Characteristics of Human Tubular Bones after Hyperthermal Treatment |
| title_full_unstemmed | Mechanical and Histological Characteristics of Human Tubular Bones after Hyperthermal Treatment |
| title_short | Mechanical and Histological Characteristics of Human Tubular Bones after Hyperthermal Treatment |
| title_sort | mechanical and histological characteristics of human tubular bones after hyperthermal treatment |
| topic | bone strain tissue heating tumor treatment hyperthermia tubular bones thermal ablation |
| url | https://www.mdpi.com/2073-8994/15/1/156 |
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