The residues 4 to 6 at the N-terminus in particular modulate fibril propagation of β<sub>2</sub>-microglobulin

The residues 4 to 6 at the N-terminus in particular modulate fibril propagation of β<sub>2</sub>-microglobulin

The ΔN6 truncation is the main posttranslational modification of β<sub>2</sub>-microglobulin (β<sub>2</sub>M) found in dialysis-related amyloid. Investigation of the interaction of wild-type (WT) β<sub>2</sub>M with N-terminally truncated variants is therefore of...

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Bibliographic Details
Main Authors: Dang Haibin, Chen Zhixian, Chen Wang, Luo Xudong, Liu Pan, Wang Liqiang, Chen Jie, Tang Xuhai, Wang Zhengzhi, Liang Yi
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2021-12-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
human β<sub>2</sub>-microglobulin
amyloid fibril
conformational stability
truncated variant
fibril propagation
atomic force microscopy
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2021017

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