Genome-wide association studies in suicidology — analysis of main results
Studies of suicide genetics can be divided into 3 periods: 1) period of classical methods of behavioral genetics; 2) candidate genes association studies, and 3) genome-wide association studies. The majority of studies using candidate genes strategy has been dedicated to main neurotransmitter systems...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2019-12-01
|
| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| Subjects: | |
| Online Access: | https://www.bekhterevreview.com/jour/article/view/306 |
| _version_ | 1797698815565758464 |
|---|---|
| author | V. A. Rozanov G. E. Mazo N. A. Kulemin A. Yu. Gorbachev E. D. Kasyanov |
| author_facet | V. A. Rozanov G. E. Mazo N. A. Kulemin A. Yu. Gorbachev E. D. Kasyanov |
| author_sort | V. A. Rozanov |
| collection | DOAJ |
| description | Studies of suicide genetics can be divided into 3 periods: 1) period of classical methods of behavioral genetics; 2) candidate genes association studies, and 3) genome-wide association studies. The majority of studies using candidate genes strategy has been dedicated to main neurotransmitter systems (serotonine, catecholamines, GABA, excitatory aminoacids system, etc.) and in the last decade — to genes of the stress-reactivity system and neurotrophins. On the other hand among main GWAS findings are genes that are involved in neurodevelopment, neuroplasticity, cell adhesion and migration, proliferation and intracellular signaling, as well as immune system functions. We consider it a confirmation of the relevance of the stressvulnerability models that imply key role of the early development and involvement of the neuroplasticity, as well as models that focus on stress as a systemic reaction of the organism in pathogenesis of suicidal behavior. It should be noted that findings of different GWAS studies most often do not coincide and in general produce rather heterogeneous picture. It may be due to differing bioinformatics approaches, phenotypes description differences and study design peculiarities. We consider that more research is needed in all three directions with involvement of NGS approaches, in particular whole-exome sequencing. |
| first_indexed | 2024-03-12T03:59:29Z |
| format | Article |
| id | doaj.art-31051b34e70e45029bd1a2adb970638d |
| institution | Directory Open Access Journal |
| issn | 2313-7053 2713-055X |
| language | Russian |
| last_indexed | 2024-03-12T03:59:29Z |
| publishDate | 2019-12-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj.art-31051b34e70e45029bd1a2adb970638d2023-09-03T11:45:19ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2019-12-0104-1586010.31363/2313-7053-2019-4-1-58-60285Genome-wide association studies in suicidology — analysis of main resultsV. A. Rozanov0G. E. Mazo1N. A. Kulemin2A. Yu. Gorbachev3E. D. Kasyanov4Saint-Petersburg State UniversityBekhterev National Medical Research Center for Psychiatry and NeurologFederal Research and Clinical Center of Physical-Chemical Medicine; ZenomeZenomeBekhterev National Medical Research Center for Psychiatry and NeurologyStudies of suicide genetics can be divided into 3 periods: 1) period of classical methods of behavioral genetics; 2) candidate genes association studies, and 3) genome-wide association studies. The majority of studies using candidate genes strategy has been dedicated to main neurotransmitter systems (serotonine, catecholamines, GABA, excitatory aminoacids system, etc.) and in the last decade — to genes of the stress-reactivity system and neurotrophins. On the other hand among main GWAS findings are genes that are involved in neurodevelopment, neuroplasticity, cell adhesion and migration, proliferation and intracellular signaling, as well as immune system functions. We consider it a confirmation of the relevance of the stressvulnerability models that imply key role of the early development and involvement of the neuroplasticity, as well as models that focus on stress as a systemic reaction of the organism in pathogenesis of suicidal behavior. It should be noted that findings of different GWAS studies most often do not coincide and in general produce rather heterogeneous picture. It may be due to differing bioinformatics approaches, phenotypes description differences and study design peculiarities. We consider that more research is needed in all three directions with involvement of NGS approaches, in particular whole-exome sequencing.https://www.bekhterevreview.com/jour/article/view/306suicide, suicidal behavior, gwas, neurodevelopmental genеs, stress-vulnerability, neuroplasticity |
| spellingShingle | V. A. Rozanov G. E. Mazo N. A. Kulemin A. Yu. Gorbachev E. D. Kasyanov Genome-wide association studies in suicidology — analysis of main results Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева suicide, suicidal behavior, gwas, neurodevelopmental genеs, stress-vulnerability, neuroplasticity |
| title | Genome-wide association studies in suicidology — analysis of main results |
| title_full | Genome-wide association studies in suicidology — analysis of main results |
| title_fullStr | Genome-wide association studies in suicidology — analysis of main results |
| title_full_unstemmed | Genome-wide association studies in suicidology — analysis of main results |
| title_short | Genome-wide association studies in suicidology — analysis of main results |
| title_sort | genome wide association studies in suicidology analysis of main results |
| topic | suicide, suicidal behavior, gwas, neurodevelopmental genеs, stress-vulnerability, neuroplasticity |
| url | https://www.bekhterevreview.com/jour/article/view/306 |
| work_keys_str_mv | AT varozanov genomewideassociationstudiesinsuicidologyanalysisofmainresults AT gemazo genomewideassociationstudiesinsuicidologyanalysisofmainresults AT nakulemin genomewideassociationstudiesinsuicidologyanalysisofmainresults AT ayugorbachev genomewideassociationstudiesinsuicidologyanalysisofmainresults AT edkasyanov genomewideassociationstudiesinsuicidologyanalysisofmainresults |