Intraocular lymphoma masquerading as unilateral hypopyon anterior uveitis: a case report
Abstract Purpose To report an unusual case of unilateral anterior segment large B-cell intraocular lymphoma (IOL) presenting as a recurrent hypopyon anterior uveitis. Case presentation A 55-year-old female was referred because of recurrent unilateral anterior hypopyon uveitis with partial response t...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-07-01
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| Series: | Journal of Ophthalmic Inflammation and Infection |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12348-022-00302-5 |
| _version_ | 1828374978595127296 |
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| author | Ghodsieh Zamani Atefeh Hajipour Babak Ganjeifar Nazanin Ebrahimiadib Seyedeh Maryam Hosseini |
| author_facet | Ghodsieh Zamani Atefeh Hajipour Babak Ganjeifar Nazanin Ebrahimiadib Seyedeh Maryam Hosseini |
| author_sort | Ghodsieh Zamani |
| collection | DOAJ |
| description | Abstract Purpose To report an unusual case of unilateral anterior segment large B-cell intraocular lymphoma (IOL) presenting as a recurrent hypopyon anterior uveitis. Case presentation A 55-year-old female was referred because of recurrent unilateral anterior hypopyon uveitis with partial response to topical corticosteroid. All of the laboratory tests, review of systems and ocular sampling results were unremarkable. Given a high concern for masquerades syndromes, cytological specimens were obtained 3 times and the last sample showed large B cell lymphoma. First, it appeared confined to the eye and initially responded favorably to local chemotherapy (methotrexate and rituximab) but later went on to develop systemic involvement. CNS lymphoma was detected on the third brain MRI 6 months following ocular involvement. At this time, systemic chemotherapy was started. In the last 18 months’ follow-up, visual acuity was 20/30 in the right eye without posterior segment or fellow eye involvement. Conclusion Unusual presentation of intraocular lymphoma as a unilateral isolated anterior hypopyon uveitis should be kept in mind. This report emphasizes the importance of precise work-ups and multiple ocular biopsies to confirm the diagnosis of intraocular lymphoma. |
| first_indexed | 2024-04-14T07:41:10Z |
| format | Article |
| id | doaj.art-310637c306064b28a25fcdee3809b71f |
| institution | Directory Open Access Journal |
| issn | 1869-5760 |
| language | English |
| last_indexed | 2024-04-14T07:41:10Z |
| publishDate | 2022-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Ophthalmic Inflammation and Infection |
| spelling | doaj.art-310637c306064b28a25fcdee3809b71f2022-12-22T02:05:29ZengSpringerOpenJournal of Ophthalmic Inflammation and Infection1869-57602022-07-011211510.1186/s12348-022-00302-5Intraocular lymphoma masquerading as unilateral hypopyon anterior uveitis: a case reportGhodsieh Zamani0Atefeh Hajipour1Babak Ganjeifar2Nazanin Ebrahimiadib3Seyedeh Maryam Hosseini4Eye Research Center, Mashhad University of Medical SciencesEye Research Center, Mashhad University of Medical SciencesDepartment of Neurosurgery, Mashhad University of Medical SciencesOphthalmology Department, Retina Service, Farabi Eye Hospital, Tehran University of Medical SciencesEye Research Center, Mashhad University of Medical SciencesAbstract Purpose To report an unusual case of unilateral anterior segment large B-cell intraocular lymphoma (IOL) presenting as a recurrent hypopyon anterior uveitis. Case presentation A 55-year-old female was referred because of recurrent unilateral anterior hypopyon uveitis with partial response to topical corticosteroid. All of the laboratory tests, review of systems and ocular sampling results were unremarkable. Given a high concern for masquerades syndromes, cytological specimens were obtained 3 times and the last sample showed large B cell lymphoma. First, it appeared confined to the eye and initially responded favorably to local chemotherapy (methotrexate and rituximab) but later went on to develop systemic involvement. CNS lymphoma was detected on the third brain MRI 6 months following ocular involvement. At this time, systemic chemotherapy was started. In the last 18 months’ follow-up, visual acuity was 20/30 in the right eye without posterior segment or fellow eye involvement. Conclusion Unusual presentation of intraocular lymphoma as a unilateral isolated anterior hypopyon uveitis should be kept in mind. This report emphasizes the importance of precise work-ups and multiple ocular biopsies to confirm the diagnosis of intraocular lymphoma.https://doi.org/10.1186/s12348-022-00302-5Vitreoretinal lymphomaDiffuse large B-cell lymphomaMasquerade syndromeHypopyon uveitisAnterior uveitis |
| spellingShingle | Ghodsieh Zamani Atefeh Hajipour Babak Ganjeifar Nazanin Ebrahimiadib Seyedeh Maryam Hosseini Intraocular lymphoma masquerading as unilateral hypopyon anterior uveitis: a case report Journal of Ophthalmic Inflammation and Infection Vitreoretinal lymphoma Diffuse large B-cell lymphoma Masquerade syndrome Hypopyon uveitis Anterior uveitis |
| title | Intraocular lymphoma masquerading as unilateral hypopyon anterior uveitis: a case report |
| title_full | Intraocular lymphoma masquerading as unilateral hypopyon anterior uveitis: a case report |
| title_fullStr | Intraocular lymphoma masquerading as unilateral hypopyon anterior uveitis: a case report |
| title_full_unstemmed | Intraocular lymphoma masquerading as unilateral hypopyon anterior uveitis: a case report |
| title_short | Intraocular lymphoma masquerading as unilateral hypopyon anterior uveitis: a case report |
| title_sort | intraocular lymphoma masquerading as unilateral hypopyon anterior uveitis a case report |
| topic | Vitreoretinal lymphoma Diffuse large B-cell lymphoma Masquerade syndrome Hypopyon uveitis Anterior uveitis |
| url | https://doi.org/10.1186/s12348-022-00302-5 |
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