Syringic acid, a novel natural phenolic acid, normalizes hyperglycemia with special reference to glycoprotein components in experimental diabetic rats
Objective: To evaluate the antidiabetic effect of syringic acid, a natural phenolic compound on the levels of glycoprotein components in plasma and tissues of alloxan induced diabetic rats. Methods: Diabetes was induced in male Wistar rats by a single intraperitoneal injection of alloxan (150 mg/kg...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Journal of Acute Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2221618913601493 |
| _version_ | 1818470093074464768 |
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| author | Jayachandran Muthukumaran Subramani Srinivasan Rantham Subramaniyam Venkatesan Vinayagam Ramachandran Udaiyar Muruganathan |
| author_facet | Jayachandran Muthukumaran Subramani Srinivasan Rantham Subramaniyam Venkatesan Vinayagam Ramachandran Udaiyar Muruganathan |
| author_sort | Jayachandran Muthukumaran |
| collection | DOAJ |
| description | Objective: To evaluate the antidiabetic effect of syringic acid, a natural phenolic compound on the levels of glycoprotein components in plasma and tissues of alloxan induced diabetic rats.
Methods: Diabetes was induced in male Wistar rats by a single intraperitoneal injection of alloxan (150 mg/kg b.w). Syringic acid (50 mg/kg b.w) was administered orally for 30 d. The effects of syringic acid on plasma glucose, insulin, C-peptide, plasma and tissue glycoproteins were studied.
Results: Oral administration of syringic acid (50 mg/kg b.w) for 30 d positively modulates the glycemic status in alloxan induced diabetic rats. The levels of plasma glucose were decreased with significant increase of plasma insulin and C-peptide level. The altered levels of plasma and tissue glycoprotein components were restored to near normal. No significant changes were noticed in normal rats treated with syringic acid.
Conclusions: The present findings suggest that syringic acid can potentially ameliorate glycoprotein components abnormalities in addition to its antidiabetic effect in experimental diabetes, further clinical studies are required to evaluate the use of syringic acid as an effective therapeutic agent for the treatment of diabetes mellitus. |
| first_indexed | 2024-04-13T21:33:09Z |
| format | Article |
| id | doaj.art-31095165966f46dbbc00d5fdcc6727c5 |
| institution | Directory Open Access Journal |
| issn | 2221-6189 |
| language | English |
| last_indexed | 2024-04-13T21:33:09Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Acute Disease |
| spelling | doaj.art-31095165966f46dbbc00d5fdcc6727c52022-12-22T02:29:04ZengWolters Kluwer Medknow PublicationsJournal of Acute Disease2221-61892013-01-012430430910.1016/S2221-6189(13)60149-3Syringic acid, a novel natural phenolic acid, normalizes hyperglycemia with special reference to glycoprotein components in experimental diabetic ratsJayachandran Muthukumaran0Subramani Srinivasan1Rantham Subramaniyam Venkatesan2Vinayagam Ramachandran3Udaiyar Muruganathan4Department of Biochemistry, Adhiparasakthi College of Arts and Science, G. B. Nagar, Kalavai, Vellore Dist – 632506, Tamil Nadu, IndiaDepartment of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar – 608002, Tamil Nadu, IndiaDepartment of Biochemistry, Adhiparasakthi College of Arts and Science, G. B. Nagar, Kalavai, Vellore Dist – 632506, Tamil Nadu, IndiaDepartment of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar – 608002, Tamil Nadu, IndiaDepartment of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar – 608002, Tamil Nadu, IndiaObjective: To evaluate the antidiabetic effect of syringic acid, a natural phenolic compound on the levels of glycoprotein components in plasma and tissues of alloxan induced diabetic rats. Methods: Diabetes was induced in male Wistar rats by a single intraperitoneal injection of alloxan (150 mg/kg b.w). Syringic acid (50 mg/kg b.w) was administered orally for 30 d. The effects of syringic acid on plasma glucose, insulin, C-peptide, plasma and tissue glycoproteins were studied. Results: Oral administration of syringic acid (50 mg/kg b.w) for 30 d positively modulates the glycemic status in alloxan induced diabetic rats. The levels of plasma glucose were decreased with significant increase of plasma insulin and C-peptide level. The altered levels of plasma and tissue glycoprotein components were restored to near normal. No significant changes were noticed in normal rats treated with syringic acid. Conclusions: The present findings suggest that syringic acid can potentially ameliorate glycoprotein components abnormalities in addition to its antidiabetic effect in experimental diabetes, further clinical studies are required to evaluate the use of syringic acid as an effective therapeutic agent for the treatment of diabetes mellitus.http://www.sciencedirect.com/science/article/pii/S2221618913601493Syringic acidDiabetes mellitusGlycoproteinsAlloxan |
| spellingShingle | Jayachandran Muthukumaran Subramani Srinivasan Rantham Subramaniyam Venkatesan Vinayagam Ramachandran Udaiyar Muruganathan Syringic acid, a novel natural phenolic acid, normalizes hyperglycemia with special reference to glycoprotein components in experimental diabetic rats Journal of Acute Disease Syringic acid Diabetes mellitus Glycoproteins Alloxan |
| title | Syringic acid, a novel natural phenolic acid, normalizes hyperglycemia with special reference to glycoprotein components in experimental diabetic rats |
| title_full | Syringic acid, a novel natural phenolic acid, normalizes hyperglycemia with special reference to glycoprotein components in experimental diabetic rats |
| title_fullStr | Syringic acid, a novel natural phenolic acid, normalizes hyperglycemia with special reference to glycoprotein components in experimental diabetic rats |
| title_full_unstemmed | Syringic acid, a novel natural phenolic acid, normalizes hyperglycemia with special reference to glycoprotein components in experimental diabetic rats |
| title_short | Syringic acid, a novel natural phenolic acid, normalizes hyperglycemia with special reference to glycoprotein components in experimental diabetic rats |
| title_sort | syringic acid a novel natural phenolic acid normalizes hyperglycemia with special reference to glycoprotein components in experimental diabetic rats |
| topic | Syringic acid Diabetes mellitus Glycoproteins Alloxan |
| url | http://www.sciencedirect.com/science/article/pii/S2221618913601493 |
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