Growth Factor Dependent Regulation of Centrosome Function and Genomic Instability by HuR

Growth Factor Dependent Regulation of Centrosome Function and Genomic Instability by HuR

The mRNA binding protein HuR is over expressed in cancer cells and contributes to disease progression through post-transcriptional regulation of mRNA. The regulation of HuR and how this relates to glioma is the focus of this report. SRC and c-Abl kinases regulate HuR sub-cellular trafficking and inf...

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Bibliographic Details
Main Authors: Natalia Filippova, Xiuhua Yang, Louis Burt Nabors
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:Biomolecules
Subjects:
ABL tyrosine kinase
cell signaling
centrosome
genomic instability
RNA binding protein
Src
Online Access:http://www.mdpi.com/2218-273X/5/1/263

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