Dendritic cell vaccination in pediatric gliomas: lessons learnt and future perspectives
Immunotherapy of malignant gliomas with autologous dendritic cells (DC) in addition to surgery and radiochemotherapy has been a focus of intense research during the past decade. Since both children and adults are affected by this highly aggressive brain tumor, 10-15% of the several hundred vaccinate...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-06-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fped.2013.00012/full |
| _version_ | 1811214068125532160 |
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| author | Matthias eEyrich Matthias eWölfl Johannes eRachor Susanne C Schreiber Paul G Schlegel |
| author_facet | Matthias eEyrich Matthias eWölfl Johannes eRachor Susanne C Schreiber Paul G Schlegel |
| author_sort | Matthias eEyrich |
| collection | DOAJ |
| description | Immunotherapy of malignant gliomas with autologous dendritic cells (DC) in addition to surgery and radiochemotherapy has been a focus of intense research during the past decade. Since both children and adults are affected by this highly aggressive brain tumor, 10-15% of the several hundred vaccinated patients represent children, making pediatric glioma patients the largest uniform pediatric vaccination cohort so far. In general, DC vaccination in malignant gliomas has been shown to be safe and several studies with nonvaccinated controls could clearly demonstrate a survival benefit for the vaccinated patients. Interestingly, children and adolescents below 20 years of age seem to benefit even more than adult patients. This review summarizes the findings of the 25 clinical trials published so far and gives a perspective how DC vaccination could be implemented as part of multimodal therapeutic strategies in the near future. |
| first_indexed | 2024-04-12T05:58:01Z |
| format | Article |
| id | doaj.art-310be1d6550842089ee5b4d4e7f07d66 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-12T05:58:01Z |
| publishDate | 2013-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-310be1d6550842089ee5b4d4e7f07d662022-12-22T03:45:07ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602013-06-01110.3389/fped.2013.0001246165Dendritic cell vaccination in pediatric gliomas: lessons learnt and future perspectivesMatthias eEyrich0Matthias eWölfl1Johannes eRachor2Susanne C Schreiber3Paul G Schlegel4University Children's Hosital WürzburgUniversity Children's Hosital WürzburgUniversity Children's Hosital WürzburgUniversity Children's Hosital WürzburgUniversity Children's Hosital WürzburgImmunotherapy of malignant gliomas with autologous dendritic cells (DC) in addition to surgery and radiochemotherapy has been a focus of intense research during the past decade. Since both children and adults are affected by this highly aggressive brain tumor, 10-15% of the several hundred vaccinated patients represent children, making pediatric glioma patients the largest uniform pediatric vaccination cohort so far. In general, DC vaccination in malignant gliomas has been shown to be safe and several studies with nonvaccinated controls could clearly demonstrate a survival benefit for the vaccinated patients. Interestingly, children and adolescents below 20 years of age seem to benefit even more than adult patients. This review summarizes the findings of the 25 clinical trials published so far and gives a perspective how DC vaccination could be implemented as part of multimodal therapeutic strategies in the near future.http://journal.frontiersin.org/Journal/10.3389/fped.2013.00012/fullImmunotherapyPediatricsClinical Trialmalignant gliomaDC vaccination |
| spellingShingle | Matthias eEyrich Matthias eWölfl Johannes eRachor Susanne C Schreiber Paul G Schlegel Dendritic cell vaccination in pediatric gliomas: lessons learnt and future perspectives Frontiers in Pediatrics Immunotherapy Pediatrics Clinical Trial malignant glioma DC vaccination |
| title | Dendritic cell vaccination in pediatric gliomas: lessons learnt and future perspectives |
| title_full | Dendritic cell vaccination in pediatric gliomas: lessons learnt and future perspectives |
| title_fullStr | Dendritic cell vaccination in pediatric gliomas: lessons learnt and future perspectives |
| title_full_unstemmed | Dendritic cell vaccination in pediatric gliomas: lessons learnt and future perspectives |
| title_short | Dendritic cell vaccination in pediatric gliomas: lessons learnt and future perspectives |
| title_sort | dendritic cell vaccination in pediatric gliomas lessons learnt and future perspectives |
| topic | Immunotherapy Pediatrics Clinical Trial malignant glioma DC vaccination |
| url | http://journal.frontiersin.org/Journal/10.3389/fped.2013.00012/full |
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