<it>IL6 and CRP </it>haplotypes are associated with COPD risk and systemic inflammation: a case-control study
<p>Abstract</p> <p>Background</p> <p>Elevated circulating levels of C-reactive protein (CRP), interleukin (IL)-6 and fibrinogen (FG) have been repeatedly associated with many adverse outcomes in patients with chronic obstructive pulmonary disease (COPD). To date, it rem...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-03-01
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| Series: | BMC Medical Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2350/10/23 |
| _version_ | 1818562592322355200 |
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| author | Passos Valéria Kotz Daniel Houwing-Duistermaat Jeanine J Spruit Martijn A Dentener Mieke A Yanbaeva Dilyara G Wouters Emiel FM |
| author_facet | Passos Valéria Kotz Daniel Houwing-Duistermaat Jeanine J Spruit Martijn A Dentener Mieke A Yanbaeva Dilyara G Wouters Emiel FM |
| author_sort | Passos Valéria |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Elevated circulating levels of C-reactive protein (CRP), interleukin (IL)-6 and fibrinogen (FG) have been repeatedly associated with many adverse outcomes in patients with chronic obstructive pulmonary disease (COPD). To date, it remains unclear whether and to what extent systemic inflammation is primary or secondary in the pathogenesis of COPD.</p> <p>The aim of this study was to examine the association between haplotypes of <it>CRP</it>, <it>IL6 </it>and <it>FGB </it>genes, systemic inflammation, COPD risk and COPD-related phenotypes (respiratory impairment, exercise capacity and body composition).</p> <p>Methods</p> <p>Eighteen SNPs in three genes, representing optimal haplotype-tagging sets, were genotyped in 355 COPD patients and 195 healthy smokers. Plasma levels of CRP, IL-6 and FG were measured in the total study group. Differences in haplotype distributions were tested using the global and haplotype-specific statistics.</p> <p>Results</p> <p>Raised plasma levels of CRP, IL-6 and fibrinogen were demonstrated in COPD patients. However, COPD population was very heterogeneous: about 40% of patients had no evidence of systemic inflammation (CRP < 3 mg/uL or no inflammatory markers in their top quartile). Global test for haplotype effect indicated association of <it>CRP </it>gene and CRP plasma levels (P = 0.0004) and <it>IL6 </it>gene and COPD (P = 0.003). Subsequent analysis has shown that <it>IL6 </it>haplotype H2, associated with an increased COPD risk (p = 0.004, OR = 4.82; 1.64 to 4.18), was also associated with very low CRP levels (p = 0.0005). None of the genes were associated with COPD-related phenotypes.</p> <p>Conclusion</p> <p>Our findings suggest that common genetic variation in <it>CRP </it>and <it>IL6 </it>genes may contribute to heterogeneity of COPD population associated with systemic inflammation.</p> |
| first_indexed | 2024-12-14T01:05:47Z |
| format | Article |
| id | doaj.art-310c1f1ee89b4de5986d13f661ba320b |
| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
| last_indexed | 2024-12-14T01:05:47Z |
| publishDate | 2009-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genetics |
| spelling | doaj.art-310c1f1ee89b4de5986d13f661ba320b2022-12-21T23:22:59ZengBMCBMC Medical Genetics1471-23502009-03-011012310.1186/1471-2350-10-23<it>IL6 and CRP </it>haplotypes are associated with COPD risk and systemic inflammation: a case-control studyPassos ValériaKotz DanielHouwing-Duistermaat Jeanine JSpruit Martijn ADentener Mieke AYanbaeva Dilyara GWouters Emiel FM<p>Abstract</p> <p>Background</p> <p>Elevated circulating levels of C-reactive protein (CRP), interleukin (IL)-6 and fibrinogen (FG) have been repeatedly associated with many adverse outcomes in patients with chronic obstructive pulmonary disease (COPD). To date, it remains unclear whether and to what extent systemic inflammation is primary or secondary in the pathogenesis of COPD.</p> <p>The aim of this study was to examine the association between haplotypes of <it>CRP</it>, <it>IL6 </it>and <it>FGB </it>genes, systemic inflammation, COPD risk and COPD-related phenotypes (respiratory impairment, exercise capacity and body composition).</p> <p>Methods</p> <p>Eighteen SNPs in three genes, representing optimal haplotype-tagging sets, were genotyped in 355 COPD patients and 195 healthy smokers. Plasma levels of CRP, IL-6 and FG were measured in the total study group. Differences in haplotype distributions were tested using the global and haplotype-specific statistics.</p> <p>Results</p> <p>Raised plasma levels of CRP, IL-6 and fibrinogen were demonstrated in COPD patients. However, COPD population was very heterogeneous: about 40% of patients had no evidence of systemic inflammation (CRP < 3 mg/uL or no inflammatory markers in their top quartile). Global test for haplotype effect indicated association of <it>CRP </it>gene and CRP plasma levels (P = 0.0004) and <it>IL6 </it>gene and COPD (P = 0.003). Subsequent analysis has shown that <it>IL6 </it>haplotype H2, associated with an increased COPD risk (p = 0.004, OR = 4.82; 1.64 to 4.18), was also associated with very low CRP levels (p = 0.0005). None of the genes were associated with COPD-related phenotypes.</p> <p>Conclusion</p> <p>Our findings suggest that common genetic variation in <it>CRP </it>and <it>IL6 </it>genes may contribute to heterogeneity of COPD population associated with systemic inflammation.</p>http://www.biomedcentral.com/1471-2350/10/23 |
| spellingShingle | Passos Valéria Kotz Daniel Houwing-Duistermaat Jeanine J Spruit Martijn A Dentener Mieke A Yanbaeva Dilyara G Wouters Emiel FM <it>IL6 and CRP </it>haplotypes are associated with COPD risk and systemic inflammation: a case-control study BMC Medical Genetics |
| title | <it>IL6 and CRP </it>haplotypes are associated with COPD risk and systemic inflammation: a case-control study |
| title_full | <it>IL6 and CRP </it>haplotypes are associated with COPD risk and systemic inflammation: a case-control study |
| title_fullStr | <it>IL6 and CRP </it>haplotypes are associated with COPD risk and systemic inflammation: a case-control study |
| title_full_unstemmed | <it>IL6 and CRP </it>haplotypes are associated with COPD risk and systemic inflammation: a case-control study |
| title_short | <it>IL6 and CRP </it>haplotypes are associated with COPD risk and systemic inflammation: a case-control study |
| title_sort | it il6 and crp it haplotypes are associated with copd risk and systemic inflammation a case control study |
| url | http://www.biomedcentral.com/1471-2350/10/23 |
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