Risk prediction of dysthyroid optic neuropathy based on CT imaging features combined the bony orbit with the soft tissue structures
PurposeTo analyze computed tomographic (CT) imaging features of patients with dysthyroid optic neuropathy (DON) retrospectively and deduce a more appropriate predictive model.MethodsThe CT scans and medical records of 60 patients with clinically proven Graves' ophthalmopathy (GO) with (26 women...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.936819/full |
| _version_ | 1818496054303129600 |
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| author | Shengnan Cheng Yangcan Ming Mang Hu Yan Zhang Fagang Jiang Xinghua Wang Zefeng Xiao |
| author_facet | Shengnan Cheng Yangcan Ming Mang Hu Yan Zhang Fagang Jiang Xinghua Wang Zefeng Xiao |
| author_sort | Shengnan Cheng |
| collection | DOAJ |
| description | PurposeTo analyze computed tomographic (CT) imaging features of patients with dysthyroid optic neuropathy (DON) retrospectively and deduce a more appropriate predictive model.MethodsThe CT scans and medical records of 60 patients with clinically proven Graves' ophthalmopathy (GO) with (26 women and 10 men) and without DON (16 women and 8 men) were retrospectively reviewed, and 20 age- and sex-matched control participants (12 women and 8 men) were enrolled consecutively. The bony orbit [orbital rim angle (ORA), medial and lateral orbital wall angles (MWA and LWA), orbital apex angle (OAA), and length of the lateral orbital wall (LWL)], and the soft tissue structures [maximum extraocular muscle diameters (Max EOMD), muscle diameter index (MDI), medial and lateral rectus bulk from inter-zygomatic line (MRIZL and LRIZL), proptosis, intraorbital optic nerve stretching length (IONSL), superior ophthalmic vein diameter (SOVD), apical crowding, and presence of intracranial fat prolapse] were assessed on a clinical workstation. The CT features among groups were compared, and a multivariate logistic regression analysis was performed to evaluate the predictive features of DON.ResultsAll bony orbital angle indicators, except ORA (p = 0.461), were statistically different among the three groups (all p < 0.05). The values of MWA, LWA, OAA, and LWL were larger in the orbits with the DON group than in the orbits without the DON group (all p < 0.05). The MDI, MRIZL, proptosis, IONSL, and SOVD were statistically significantly different among the three groups (all p < 0.05), in which the orbits with the DON group were significantly higher than the orbits without the DON group and control group. The apical crowding was more severe in the orbits with the DON group than in the orbits without the DON group (p = 0.000). There were no significant differences in the LRIZL and the presence of intracranial fat prolapse (all p > 0.05). The multivariate regression analysis showed that the MWA, MDI, and SOVD were the independent factors predictive of DON. The sensitivity and specificity for the presence of DON by combining these three indicators were 89 and 83%, respectively.ConclusionBone and soft tissue CT features are useful in the risk prediction of DON, especially the MWA, MDI, and SOVD were the independent factors predictive of DON. |
| first_indexed | 2024-12-10T18:28:23Z |
| format | Article |
| id | doaj.art-310c74c2a9314f11bade44eaab78f1d6 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-10T18:28:23Z |
| publishDate | 2022-08-01 |
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| series | Frontiers in Medicine |
| spelling | doaj.art-310c74c2a9314f11bade44eaab78f1d62022-12-22T01:38:01ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-08-01910.3389/fmed.2022.936819936819Risk prediction of dysthyroid optic neuropathy based on CT imaging features combined the bony orbit with the soft tissue structuresShengnan Cheng0Yangcan Ming1Mang Hu2Yan Zhang3Fagang Jiang4Xinghua Wang5Zefeng Xiao6Department of Ophthalmology, Wuhan Hospital of Traditional Chinese and Western Medicine, Wuhan, ChinaDepartment of Pediatrics, Wuhan Hospital of Traditional Chinese and Western Medicine, Wuhan, ChinaDepartment of Ophthalmology, Wuhan Hospital of Traditional Chinese and Western Medicine, Wuhan, ChinaDepartment of Ophthalmology, Wuhan Hospital of Traditional Chinese and Western Medicine, Wuhan, ChinaDepartment of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Ophthalmology, Wuhan Hospital of Traditional Chinese and Western Medicine, Wuhan, ChinaPurposeTo analyze computed tomographic (CT) imaging features of patients with dysthyroid optic neuropathy (DON) retrospectively and deduce a more appropriate predictive model.MethodsThe CT scans and medical records of 60 patients with clinically proven Graves' ophthalmopathy (GO) with (26 women and 10 men) and without DON (16 women and 8 men) were retrospectively reviewed, and 20 age- and sex-matched control participants (12 women and 8 men) were enrolled consecutively. The bony orbit [orbital rim angle (ORA), medial and lateral orbital wall angles (MWA and LWA), orbital apex angle (OAA), and length of the lateral orbital wall (LWL)], and the soft tissue structures [maximum extraocular muscle diameters (Max EOMD), muscle diameter index (MDI), medial and lateral rectus bulk from inter-zygomatic line (MRIZL and LRIZL), proptosis, intraorbital optic nerve stretching length (IONSL), superior ophthalmic vein diameter (SOVD), apical crowding, and presence of intracranial fat prolapse] were assessed on a clinical workstation. The CT features among groups were compared, and a multivariate logistic regression analysis was performed to evaluate the predictive features of DON.ResultsAll bony orbital angle indicators, except ORA (p = 0.461), were statistically different among the three groups (all p < 0.05). The values of MWA, LWA, OAA, and LWL were larger in the orbits with the DON group than in the orbits without the DON group (all p < 0.05). The MDI, MRIZL, proptosis, IONSL, and SOVD were statistically significantly different among the three groups (all p < 0.05), in which the orbits with the DON group were significantly higher than the orbits without the DON group and control group. The apical crowding was more severe in the orbits with the DON group than in the orbits without the DON group (p = 0.000). There were no significant differences in the LRIZL and the presence of intracranial fat prolapse (all p > 0.05). The multivariate regression analysis showed that the MWA, MDI, and SOVD were the independent factors predictive of DON. The sensitivity and specificity for the presence of DON by combining these three indicators were 89 and 83%, respectively.ConclusionBone and soft tissue CT features are useful in the risk prediction of DON, especially the MWA, MDI, and SOVD were the independent factors predictive of DON.https://www.frontiersin.org/articles/10.3389/fmed.2022.936819/fulldysthyroid optic neuropathyrisk predictionCT imagingbony orbitsoft tissue structures |
| spellingShingle | Shengnan Cheng Yangcan Ming Mang Hu Yan Zhang Fagang Jiang Xinghua Wang Zefeng Xiao Risk prediction of dysthyroid optic neuropathy based on CT imaging features combined the bony orbit with the soft tissue structures Frontiers in Medicine dysthyroid optic neuropathy risk prediction CT imaging bony orbit soft tissue structures |
| title | Risk prediction of dysthyroid optic neuropathy based on CT imaging features combined the bony orbit with the soft tissue structures |
| title_full | Risk prediction of dysthyroid optic neuropathy based on CT imaging features combined the bony orbit with the soft tissue structures |
| title_fullStr | Risk prediction of dysthyroid optic neuropathy based on CT imaging features combined the bony orbit with the soft tissue structures |
| title_full_unstemmed | Risk prediction of dysthyroid optic neuropathy based on CT imaging features combined the bony orbit with the soft tissue structures |
| title_short | Risk prediction of dysthyroid optic neuropathy based on CT imaging features combined the bony orbit with the soft tissue structures |
| title_sort | risk prediction of dysthyroid optic neuropathy based on ct imaging features combined the bony orbit with the soft tissue structures |
| topic | dysthyroid optic neuropathy risk prediction CT imaging bony orbit soft tissue structures |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.936819/full |
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